Why More Isn’t Always Better For DNA

The video discusses the collaborative efforts of Drs. Harry Orr and Huda Zogby in discovering the genetic basis of SCA One, a neurodegenerative disease. Their work highlights the importance of collaboration over competition in scientific research. They identified the role of CAG repeat expansions in the disease's progression and explored genetic anticipation. Although they have made significant progress in understanding and potentially treating SCA One, challenges remain in translating these findings from mice to humans. Their contributions earned them the 2022 Kavli Prize in Neuroscience.

What was the main reason for the collaboration between Doctors Orr and Zogby?

• They realized they were researching the same disease.

• They were competing for the same prize.

• They were assigned by their university to work together.

• They were both working on different diseases.

What is the phenomenon called when a genetic condition becomes more severe with each generation?

• Adaptation

• Evolution

• Anticipation

• Mutation

Which other neurological disease did Orr and Zogby compare SCA One to in their research?

• Parkinson's disease

• Alzheimer's disease

• Myotonic dystrophy

• Huntington's disease

What did Orr and Zogby discover about the DNA of people diagnosed with SCA One?

• They lack a specific protein.

• They have an expansion of CAG repeats.

• They have a unique chromosome.

• They have fewer nucleotides.

How did the number of CAG repeats affect the severity of SCA One symptoms?

• The number of repeats had no effect.

• More repeats led to more severe symptoms.

• Fewer repeats led to more severe symptoms.

• More repeats led to milder symptoms.

What was the outcome of Orr and Zogby's research on genetically modified mice?

• The mice showed no symptoms of SCA One.

• The mice showed delayed symptoms and lived longer.

• The mice developed new symptoms.

• The mice lived shorter lives.

What is the ultimate goal of Orr and Zogby's ongoing research?

• To win more scientific awards.

• To develop a human therapy for SCA One.

• To find a cure for all neurodegenerative diseases.

• To study other genetic diseases.