TCA Cycle 2

The video provides a detailed explanation of the TCA cycle, highlighting key enzymes and reactions. It covers the conversion of Succinyl CoA to succinate, the role of succinate dehydrogenase, and the formation of fumarate. The video also explains the conversion of fumarate to malate and then to oxaloacetate, completing the cycle. Key energy yields, including NADH, FADH2, and GTP, are discussed, along with their roles in the electron transport chain.

What is the primary function of succinyl CoA synthetase in the TCA cycle?

• To generate GTP from GDP

• To reduce NAD+ to NADH

• To oxidize malate to oxaloacetate

• To convert succinate to fumarate

Which enzyme is part of the inner mitochondrial membrane and plays a role in the electron transport chain?

• Succinate dehydrogenase

• Malate dehydrogenase

• Citrate synthase

• Fumarate hydratase

What is the significance of the trans configuration in the conversion of succinate to fumarate?

• It allows the enzyme to bind more effectively

• It prevents the formation of a chiral center

• It is necessary for the subsequent reaction with fumarate hydratase

• It ensures the production of L-malate

Which isomer of malate is specifically produced by fumarate hydratase?

• Cis-malate

• L-malate

• Trans-malate

• D-malate

What is the role of malate dehydrogenase in the TCA cycle?

• To reduce NAD+ to NADH

• To generate ATP from ADP

• To convert fumarate to malate

• To oxidize malate to oxaloacetate

Which enzyme is responsible for the regeneration of citrate in the TCA cycle?

• Fumarate hydratase

• Malate dehydrogenase

• Citrate synthase

• Succinate dehydrogenase

What distinguishes citrate synthase from other enzymes in the TCA cycle?

• It is a Michaelis-Menten enzyme

• It is an allosteric enzyme

• It is reversible

• It produces FADH2

How many NADH molecules are produced per acetyl CoA in the TCA cycle?

• 1

• 2

• 4

• 3

Which enzyme in the TCA cycle is responsible for producing GTP?

• Isocitrate dehydrogenase

• Alpha-ketoglutarate dehydrogenase

• Succinyl CoA synthetase

• Malate dehydrogenase

What is the fate of the carbon dioxide produced in the TCA cycle?

• It is stored in the mitochondria

• It is exhaled as a waste product

• It is converted to ATP

• It is used in the electron transport chain