Histidine Biosynthesis AICAR Production

The video explains the biosynthesis of histidine, an essential amino acid not synthesized in humans. It details the unique pathway of histidine synthesis, which is distinct from other aromatic amino acids as it involves ATP and PRPP rather than chorismate. The process includes several steps with intermediates like Icar, which is also used in purine biosynthesis. The final steps involve converting intermediates to histidine through enzymatic reactions. Histidine plays roles in protein synthesis and as a neurotransmitter, and its synthesis is closely related to nucleotide metabolism.

Which amino acid is not synthesized from chorismate and is essential in the human diet?

• Phenylalanine

• Histidine

• Tyrosine

• Tryptophan

What is the initial nucleophilic attack in histidine synthesis responsible for?

• Releasing pyrophosphate

• Forming a bond with ribose 5-phosphate

• Breaking down ATP

• Creating a new amino acid

What is the role of Icar in bacterial histidine synthesis?

• It is a waste product

• It is a precursor to tyrosine

• It is used in purine biosynthesis

• It is converted to ATP

Which enzyme is responsible for the conversion of imidazole glycerol phosphate in histidine synthesis?

• Dehydrogenase

• Transaminase

• Phosphatase

• Dehydratase

What is the final product of histidine synthesis?

• Histamine

• Histidine

• Icar

• ATP

How is histidine related to the immune system?

• It is a precursor to antibodies

• It is converted to histamine

• It is used in white blood cell production

• It is a neurotransmitter

Why is histidine not classified with other aromatic amino acids in terms of biosynthesis?

• It has a unique synthesis pathway involving nucleotides

• It is synthesized from chorismate

• It is not essential

• It is not aromatic