Clindamycin | Bacterial Targets, Mechanism of Action, Adverse Effects

The video tutorial discusses Clindamycin, a lincosamide antibiotic, highlighting its absorption, bone penetration, and inability to cross the blood-brain barrier. It targets gram-positive aerobes and anaerobes, treating infections like osteomyelitis and toxic shock syndrome. Clindamycin inhibits protein synthesis by binding to the 50S ribosome, acting as a bacteriostatic or bactericidal agent. Side effects include pseudomembranous colitis and gastrointestinal issues.

Which class of antibiotics does Clindamycin belong to?

• Lincosamides

• Cephalosporins

• Macrolides

• Penicillins

What type of bacteria is Clindamycin NOT effective against?

• Gram-negative aerobes

• Gram-positive aerobes

• Anaerobes

• Gram-positive anaerobes

For which condition is Clindamycin used in combination with penicillin?

• Osteomyelitis

• Toxic shock syndrome

• Acne

• Pneumonia

What is the primary mechanism of action of Clindamycin?

• Inhibits protein synthesis

• Inhibits cell wall synthesis

• Inhibits folic acid synthesis

• Disrupts DNA replication

What is a major risk associated with Clindamycin use?

• Liver toxicity

• Kidney failure

• Pseudomembranous colitis

• Heart arrhythmia