T Cell Development and Maturation - T Cells are COOL!

Where do T cells begin their developmental journey?

• Lymph nodes

• Bone marrow

• Spleen

• Thymus

What is the role of the thymus in T cell development?

• To mature T cells

• To store lymphocytes

• To produce red blood cells

• To filter blood

What are double negative T cells characterized by?

• Absence of CD4 and CD8

• Presence of T cell receptors

• Presence of CD4 and CD8

• Absence of T cell receptors

What happens during positive selection in the thymus?

• T cells that bind to foreign antigens are selected

• T cells that bind to MHC molecules are selected

• T cells that do not bind to any molecules are selected

• T cells that bind to self-antigens are selected

What is the purpose of negative selection in T cell development?

• To activate T cells against pathogens

• To promote T cell proliferation

• To eliminate T cells that recognize self-antigens

• To ensure T cells recognize self-antigens

What type of T cell is characterized by the presence of CD4?

• Memory T cell

• Cytotoxic T cell

• Regulatory T cell

• Helper T cell

What determines whether a T cell becomes a helper or cytotoxic T cell?

• The presence of CD28

• The type of MHC molecule it binds to

• The type of antigen it encounters

• The presence of CD3