Non-Canonical NF-kB Signaling Pathway | Mechanism and Function

The video tutorial explains the noncanonical NF Kappa B signaling pathway, highlighting its differences from the canonical pathway, its role in immune system processes, and its implications in diseases like cancer. The mechanism of action involves various proteins and receptors, leading to gene expression changes that promote cell survival. The tutorial concludes with a preview of future lessons on related topics.

What is a key difference between the canonical and noncanonical NF Kappa B pathways?

• The canonical pathway is involved in osteoclast differentiation.

• The noncanonical pathway involves B cell maturation.

• The noncanonical pathway is faster to activate.

• The canonical pathway uses IK Alpha.

In the inactivated state of the noncanonical NF Kappa B pathway, what happens to Nik?

• It translocates to the nucleus.

• It binds to P-100 and Rel B.

• It is ubiquitinated and degraded.

• It is phosphorylated by IKK Alpha.

Which receptor is NOT involved in the activation of the noncanonical NF Kappa B pathway?

• TCR

• BAFF-R

• CD40

• LTBR

What is the result of the increase in Nik levels during the activation of the noncanonical pathway?

• Degradation of BCL2.

• Phosphorylation of IKK Beta.

• Ubiquitination of TRAF3.

• Formation of an inactive P-100 and Rel B dimer.

What is the role of the active P52 and Rel B dimer in the nucleus?

• It phosphorylates IKK Alpha.

• It degrades P-100.

• It induces the expression of anti-apoptotic genes.

• It inhibits BCL2 expression.

Which protein is inhibited by the active P52 and Rel B dimer?

• IKK Alpha

• BCL-XL

• BIM

• TRAF2

What is a potential consequence of the noncanonical NF Kappa B pathway's involvement in cancer?

• Reduced osteoclast differentiation.

• Increased apoptosis in immune cells.

• Decreased expression of anti-apoptotic proteins.

• Enhanced B cell survival.