AKT Signaling Pathway | Regulation and Downstream Effects

The video introduces the AKT signaling pathway, detailing its activation, regulation, and role in cellular functions. AKT, also known as protein kinase B, is crucial in processes like glucose uptake, protein synthesis, and cell survival. It is activated by growth signals and regulated by phosphatases. The pathway's significance in diseases such as cancer and diabetes is highlighted, emphasizing its role in increasing anabolism and decreasing catabolism.

What is another name for AKT?

• Protein kinase A

• Protein kinase B

• Protein kinase C

• Protein kinase D

Which type of receptor is involved in the activation of AKT signaling?

• Ion channel receptor

• Steroid receptor

• Nuclear receptor

• Receptor tyrosine kinase

What is the role of PDK1 in AKT activation?

• It inhibits AKT activation

• It phosphorylates AKT at threonine 308

• It recruits AKT to the cell membrane

• It dephosphorylates AKT

How does AKT affect glucose uptake in cells?

• It blocks glucose entry into the cell

• It inhibits GLUT4 translocation

• It promotes GLUT4 translocation

• It decreases insulin sensitivity

Which complex is activated by AKT to increase protein synthesis?

• Ras complex

• mTOR complex 2

• mTOR complex 1

• AMPK complex

What is one way the AKT signaling pathway is turned off?

• By phosphorylating AKT

• By activating PDK1

• By converting PIP3 to PIP2

• By increasing mTOR activity

What is the overall effect of AKT signaling on cellular metabolism?

• Increases anabolism and decreases catabolism

• Increases catabolism and decreases anabolism

• Decreases both anabolism and catabolism

• Has no effect on metabolism