Coagulation (Clotting) Cascade and Secondary Hemostasis

The video tutorial explains the coagulation cascade, breaking it down into initiation and amplification phases. It covers the roles of various factors, including tissue factor, Thrombin, and factors 7, 10, 11, 9, 8, and 13. The intrinsic and extrinsic pathways are discussed, highlighting their differences and the common pathway they share. Tips and tricks are provided to help remember the sequence of events in the cascade.

What is the initial trigger for the coagulation cascade?

• Release of calcium

• Formation of fibrin

• Activation of factor 12

• Exposure of endothelium

Which factor is known as 'lucky number 7' in the coagulation cascade?

• Factor 13

• Factor 5

• Factor 7

• Factor 10

What role does Thrombin play in the coagulation cascade?

• It forms a complex with calcium

• It dissolves fibrin

• It activates several other factors

• It inhibits factor 10

Which factors form a complex with phospholipids and calcium to activate large amounts of factor 10?

• Factors 11 and 12

• Factors 8 and 9

• Factors 5 and 7

• Factors 2 and 13

What is the result of large amounts of Thrombin in the coagulation cascade?

• Dissolution of the clot

• Activation of factor 12

• Conversion of Fibrinogen to soluble fibrin monomers

• Inhibition of factor 5

What is the final step in forming a stable clot in the coagulation cascade?

• Activation of factor 7

• Conversion of soluble fibrin monomers to insoluble fibrin polymers

• Release of tissue factor

• Activation of factor 12

What is the role of factor 13 in the coagulation cascade?

• It inhibits Thrombin

• It converts soluble fibrin monomers to insoluble fibrin polymers

• It forms a complex with factor 10

• It activates factor 7

Which pathway involves factor 12 in the coagulation cascade?

• Extrinsic pathway

• Common pathway

• Intrinsic pathway

• Fibrinolytic pathway

What is the common pathway in the coagulation cascade?

• The pathway involving factor 12

• The pathway that only involves Thrombin

• The pathway that starts with factor 7

• The pathway shared by both intrinsic and extrinsic pathways

Which factor is considered redundant in the human body but important in laboratory tests?

• Factor 5

• Factor 10

• Factor 12

• Factor 7