Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

The video provides an overview of the WNT signaling pathway, explaining its role in growth and development, and its regulation through beta catenin degradation. It discusses the pathway's activation, the role of TCF in gene expression, and the impact of mutations, particularly in the APC gene, on cancer development. The video concludes with a summary of the pathway's importance in cellular processes and cancer pathogenesis.

What is the primary role of the WNT signaling pathway in embryonic development?

• Regulation of heart development

• Inhibition of cell growth

• Activation of frizzled receptors

• Destruction of beta-catenin

Which complex is responsible for the degradation of beta-catenin in the inactivated state of the WNT pathway?

• LRP complex

• Destruction complex

• Frizzled complex

• TCF complex

What happens to beta-catenin levels when the WNT pathway is activated?

• They remain unchanged

• They are destroyed by the destruction complex

• They increase due to lack of ubiquitination

• They decrease due to proteasomal degradation

How does the activation of frizzled receptors affect the destruction complex?

• It inhibits the destruction complex

• It has no effect on the destruction complex

• It degrades the destruction complex

• It enhances the destruction complex

What role does TCF play in the WNT signaling pathway?

• It inhibits frizzled receptors

• It phosphorylates LRP

• It mediates genetic action

• It degrades beta-catenin

What is the consequence of an APC mutation in the WNT signaling pathway?

• Increased beta-catenin degradation

• Stabilization of beta-catenin

• Activation of frizzled receptors

• Decreased beta-catenin levels

Why is the WNT signaling pathway important in cancer pathogenesis?

• It inhibits cell proliferation

• It decreases embryonic development

• It regulates cell death

• It increases growth and proliferation