Lipoprotein Physiology & Pharmacology of LDLs, HDLs, & TAGs

The video tutorial covers cholesterol biosynthesis, highlighting the liver's role and the two sources of cholesterol: de Novo synthesis and dietary intake. It explains the cholesterol biosynthetic pathway, focusing on acetyl COA and HMG COA. The function and transport of lipoproteins like VLDL, LDL, and HDL are discussed, emphasizing their roles in cholesterol distribution and reverse transport. The tutorial also examines statin drugs, their effects on cholesterol and LDL synthesis, and their side effects. Other cholesterol-lowering drugs, such as niacin, fibrates, bile acid resins, and absorption inhibitors, are also reviewed.

Discuss the importance of cholesterol in mammalian life.

What is the difference between primary and secondary prevention in the context of statin use?

How do bile acid binding resins affect cholesterol levels?

Explain the mechanism of action of intestinal absorption inhibitors.