Biosignaling - Canonical Wnt β-catenin Signaling

The video tutorial explains the canonical Wnt signaling pathway, focusing on the role of Wnt as a chemical signal that binds to receptors like Frizzled and LPR 6. It details the formation and function of the beta-catenin destruction complex, which regulates gene expression by phosphorylating beta-catenin, leading to its degradation. When Wnt binds to its receptors, this complex is inactivated, allowing beta-catenin to enter the nucleus and activate target genes. The tutorial emphasizes the pathway's importance in developmental biology and cellular changes.

Discuss the differences between canonical and non-canonical Wnt signaling pathways.

What is the role of TCF in the Wnt signaling pathway?

How does the presence of Wnt affect the transcription of target genes?