Hedgehog Signaling Pathway in Vertebrates | Purpose and Mechanism

The video tutorial explains the Hedgehog signaling pathway in vertebrates, comparing it to invertebrates. It covers the pathway's roles in development, patterning, and tissue repair, and introduces concepts like graded signaling and organ-specific gene induction. Differences between vertebrate and invertebrate signaling are highlighted, focusing on the primary cilium and Glee proteins. The video details the inactivation and activation mechanisms of the pathway, emphasizing the roles of proteins like Smoothened and Sonic Hedgehog. The tutorial concludes with a summary of key points.

Explain the significance of primary cilia in Hedgehog signaling.

What is the role of Sonic Hedgehog in the Hedgehog signaling pathway?

What happens to Glee proteins when the Hedgehog signaling pathway is inactivated?