Macroautophagy | Transcriptional Regulation: Lesson 2

The video discusses transcriptional regulation of macroautophagy, focusing on transcriptional repressors like Zach Scan 3, HSF1, TCF4, XBP1, FXR, and NF Kappa B. Each repressor's role in either suppressing or enhancing macroautophagy is explained, highlighting their interactions with various proteins and pathways. The video emphasizes the dual functions of some repressors, such as XBP1 and NF Kappa B, in both upregulating and downregulating specific proteins, impacting the macroautophagy pathway.

Describe the role of XBP1 in the macrophage pathway.

How does FXR function as a repressor in the macroautophagy pathway?

What are the effects of E2F1 on macroautophagy, and how is it regulated by NF Kappa B?