061 The Bohr Effect

In this episode, Leslie Samuel explains the Bohr Effect, focusing on how carbon dioxide and pH levels influence hemoglobin's affinity for oxygen. The video reviews the oxygen dissociation curve and discusses how exercise and cellular respiration affect oxygen release. The formation of carbamate and its role in stabilizing deoxygenated hemoglobin is also covered. The episode concludes with resources for further learning.

Describe the chemical reaction that occurs when carbon dioxide and water combine.

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Explain how carbon dioxide production affects blood pH and hemoglobin's oxygen affinity.

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What is the Bohr effect and how does it relate to hemoglobin's affinity for oxygen?

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How does the oxygen dissociation curve shift in response to changes in pH?

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Discuss the relationship between cellular respiration and the Bohr effect.

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What role does lactic acid play in the context of the Bohr effect during exercise?

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What is the significance of the N-terminal amino group in hemoglobin's function?

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What happens to hemoglobin's stability in the deoxygenated form due to the Bohr effect?

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In what way does the Bohr effect facilitate oxygen delivery to tissues during exercise?

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How does the production of bicarbonate relate to the Bohr effect?

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