Mechanism of Long-Term Potentiation of Synapses

The video tutorial explains long term potentiation (LTP) in neurons, emphasizing its role in strengthening existing synaptic connections rather than creating new ones. It highlights the concept of neuroplasticity and how LTP is crucial for efficient learning and memory recall. The molecular mechanism of LTP involves the recruitment of AMPA receptors to the postsynaptic membrane, facilitated by proteins like PKM Zeta and calmodulin kinase 2. The tutorial also touches on the role of calcium influx in activating these proteins, ultimately enhancing synaptic sensitivity and efficiency.

Explain how increased depolarization of a neuron affects its synaptic connections.

What is the role of PKM Zeta in the regulation of AMPA receptors during long term potentiation?

How does calmodulin kinase 2 contribute to the process of long term potentiation?

What happens to AMPA receptors when a neuron is not stimulated frequently?