Why Biting Ice Cream Hurts So Bad

The video explores why cold teeth feel more painful than cold skin, focusing on the TRPC5 receptor. Unlike skin, which uses TRPM8 to sense cold, teeth rely on TRPC5. This receptor is more prevalent in areas with cavities, explaining why tooth decay increases cold sensitivity. Research shows that TRPC5 is mainly found in odontoblasts, cells between enamel and pulp. Teeth become hypersensitive to cold when inflamed, unlike skin, which becomes heat sensitive. The findings highlight the unique cold sensitivity of teeth and suggest further research is needed.

What experimental method did researchers use to study the cold sensitivity of teeth?

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In what way do inflamed teeth differ from inflamed skin in terms of sensitivity?

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