Mechanisms of Spasticity and Baclofen [Biochemical & Macroscopic]

The video tutorial explains the role of calcium in neurotransmitter exocytosis at the axon terminal, focusing on glutamate and substance P. It discusses the function of GABA B receptors and the effects of baclofen in treating spasticity by inhibiting calcium influx and facilitating potassium efflux. The tutorial also covers motor neuron pathways, the concept of spasticity, and the stretch reflex mechanism. Baclofen's role in reducing spasticity and its impact on muscle control is highlighted.

Explain the role of muscle spindles in the stretch reflex.

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Discuss the concept of hypertonus in relation to upper motor neuron lesions.

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What are the effects of baclofen on spasticity and how does it influence muscle tone?

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What is the difference between flexor and extensor synergy in the context of spasticity?

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