Nucleotide Metabolism | Purine Biosynthesis 2: IMP to AMP & GMP

The video explains the biosynthesis of adenylate (AMP) and guanylate (GMP) from inosine monophosphate (IMP). It details the enzymatic pathways for converting IMP into AMP and GMP, highlighting the role of enzymes like adenylosuccinate synthetase and IMP dehydrogenase. The video also discusses the regulatory mechanisms that balance AMP and GMP synthesis, emphasizing allosteric regulation and feedback inhibition. The importance of maintaining a balance between purine nucleotides is underscored, with ATP and GTP playing crucial roles in this regulation.

What is the role of IMP in the biosynthesis of AMP and GMP?

Describe the enzymatic process that converts IMP to AMP.

Explain how GMP is synthesized from IMP.

What is the significance of allosteric regulation in the synthesis of AMP and GMP?

How do AMP and GMP levels affect each other's synthesis?

Discuss the feedback inhibition mechanism involving AMP and GMP.

What are the substrates used in the synthesis of AMP and GMP?