Tryptophan Metabolism (Degradation) and the Kynurenine Pathway

The video explains the kynurenine pathway, which degrades tryptophan, an essential amino acid. Tryptophan is crucial for producing serotonin and melatonin. The pathway involves enzymes like IDO and TDO, activated by stress and cytokines, leading to metabolites such as quinolinic acid, which has neurotoxic effects and is linked to psychiatric disorders. Diseases like depression, ALS, and Parkinson's are associated with disruptions in this pathway. The video concludes with a call to action for viewers to engage with the content.

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