Porphyrins | Heme b Biosynthesis and its Regulation

The video explains heme biosynthesis, highlighting its role as a key porphyrin and iron-containing coenzyme in various biological processes. It details the pathways for synthesizing delta aminolevulinic acid (Ala) in eukaryotes and bacteria, and the conversion of Ala to heme through a series of enzymatic reactions. The localization of these enzymes in cellular compartments like mitochondria and cytoplasm is discussed, along with the regulation of heme synthesis, focusing on the role of Ala synthase and feedback mechanisms.

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