The video explains the itch-scratch cycle, where scratching provides temporary relief by sending pain signals that overwhelm itch signals. However, serotonin released to dull pain can intensify the itch, perpetuating the cycle. Researchers have identified specific receptors like GRPR involved in this process. Disrupting serotonin and GRPR interaction could offer treatment for chronic itch conditions. Ongoing research aims to better understand these mechanisms.

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