Detoxification of Cyanide by Thiosulfate Sulfotransferase: Physiology and Mechanism

The video tutorial explores the enzyme rhodanese, also known as thiosulfate sulfotransferase, which performs two main functions: biosynthesis of thiosulfate and detoxification of hydrogen cyanide. The enzyme's mechanism involves thioredoxin dependency and active site interactions with arginine residues. The process results in the formation of thiocyanate, which is excreted from the body. The tutorial provides a detailed explanation of the enzyme's role in detoxifying cyanide and the biochemical pathways involved.

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