Methotrexate (Rheumatoid Arthritis Drug)

The video tutorial discusses methotrexate, a non-biologic DMARD used to treat rheumatoid arthritis (RA). Initially developed for cancer, methotrexate was found effective for RA due to its ability to inhibit enzymes involved in inflammation. It functions as a pro drug, converting into an active form that accumulates in cells. Methotrexate's anti-inflammatory effects are mediated through adenosine receptors and inhibition of cytokines. Despite its efficacy, methotrexate has side effects, including potential liver damage and folic acid deficiency. It is crucial to monitor patients and avoid use during pregnancy.

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