Spliceosome Assembly and Splicing of mRNA

The video explains the process of splicing in mRNA, focusing on the role of spliceosomes, which are protein-dependent complexes that facilitate the removal of introns and the joining of exons. It contrasts this with self-splicing introns, which do not require proteins. The video details the assembly of spliceosomes, involving small nuclear ribonucleoproteins (snRNPs) like U1, U2, U4, U5, and U6, and the ATP-dependent steps required for their function. The mechanism of splicing, including lariat formation and exon ligation, is described, highlighting the similarities with group 2 self-splicing introns. The video concludes with a brief mention of the next topic, polyadenylation of mRNA.

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