Polycythemia Vera Quiz

What is the primary cell type involved in Polycythemia Vera?

• Red blood cells

• White blood cells

• Lymphocytes

• Platelets

Where in the body are pluripotent hematopoietic stem cells primarily located?

• Liver

• Spleen

• Bone marrow

• Kidneys

What is the role of erythropoietin in the body?

• To destroy old red blood cells

• To regulate white blood cell count

• To stimulate red blood cell production

• To increase platelet production

What mutation is responsible for the overproduction of red blood cells in Polycythemia Vera?

• Jak2 kinase mutation

• p53 mutation

• EGFR mutation

• BRCA1 mutation

What condition is characterized by an enlarged spleen due to excessive red blood cell destruction?

• Thrombosis

• Splenomegaly

• Gout

• Hepatomegaly

What causes gout in patients with Polycythemia Vera?

• Excessive platelet production

• Increased uric acid from DNA breakdown

• High levels of histamine

• Decreased oxygen levels

Which of the following is a common diagnostic test for Polycythemia Vera?

• Liver function test

• Jak2 kinase mutation test

• Urinalysis

• Blood glucose test

What is the first line of treatment for reducing red blood cell count in Polycythemia Vera?

• Chemotherapy

• Phlebotomy

• Surgery

• Radiation therapy

Which drug is used to decrease uric acid production in Polycythemia Vera?

• Aspirin

• Hydroxyurea

• Ibuprofen

• Metformin

What is the role of interferon alpha in the treatment of Polycythemia Vera?

• To decrease platelet count

• To increase red blood cell production

• To increase destruction of proerythroblasts

• To reduce spleen size