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GENE MUTATION

Total questions: 20

Worksheet time: 13mins

Name
Class
Date
1.
Any change in the sequence of DNA is...
a)
transgenic shift
b)
Single Genotype
c)
Monohybrid Trait
d)
Mutation
2.
Which change below would result in a different Amino Acid? 
3'-GCT-5'
a)
GTT
b)
TCT
c)
TCC
d)
GCA
3.
What type of gene mutation has occurred here? 
T-G-A-C-C-A
T-G-A-C-C-A-A
a)
Base Substitution
b)
Base Deletion
c)
Base Insertion
d)
Frameshift 
4.
What type of gene mutation has occurred here? Normal-
AGA-TTC-ATA-GCG
Mutant-
AGA-TTC-AAT-AGC-G
a)

Base deletion

b)

Base insertion

c)

Base substitution

d)
nonsense
5.
DNA molecule segment is : TTACGCAAG
The mutated DNA segment is TTACGCAAC. This is an example of ___ mutation.
a)
Base Substitution
b)
Base Insertion
c)
Base Inversion
d)
Translocation
6.
A mutation that does NOT show up through protein function is called
a)
deletion mutation
b)
inversion mutation
c)
silent mutation
d)
transverse mutation
7.
Where do mutations occur?
a)
DNA and RNA
b)
DNA 
c)
RNA
d)
mRNA and tRNA
8.
A nonsense mutation produced _________.
a)
A same polypeptide chain
b)
A slightly altered polypeptide chain
c)
A shift in the reading frame
d)
The regulatory sequence being altered.
9.
A base pair substitution can result in all of the following except __________.
a)
Missense mutation
b)
Frameshift Mutation
c)
Silent Mutation
d)
Nonsense mutation
10.

What kind of mutation is the result of an base insertion?

a)
Silent Mutation
b)
Missense mutation
c)
Nonsense mutation
d)
Frameshift mutation
11.

What type of mutation is this?

a)

Nonsense mutation

b)

Missense mutation

c)

Silent mutation

d)

Frameshift mutation

12.

In sickle cell anaemia, what happens to the haemoglobin and to the red blood cells?

a)

Stiff, Crescent shaped

b)

Stiff, Round

c)

Flexible, Crescent shaped

d)

Flexible, Round

13.

What type of mutation causing sickle cell anaemia?

a)

Nonsense mutation cause by base substitution

b)

Missense mutation cause by base substitution

c)

Silent mutation cause by base substitution

d)

Base Deletion

e)

Base Insertion

14.

Why are base insertion and base deletion mutations so harmful?

a)
They change all of the codons from the mutation on down the line, which changes the amino acid sequence
b)
They insert things that an organism doesn't need.
c)
They often delete things that organisms need.
d)
Insertion and deletions are not any more harmful than substitution mutations.
15.

A permanent change in the DNA sequence

which can affect a single gene or group of genes

a)

Homeostasis

b)

Somatic Cell

c)

Chromosomal Mutation

d)

Gene Mutation

16.

This type of base substitution codes for a stop codon

a)
Missense
b)
Nonsense
c)
Silent
d)
Deletion
17.

A type of base substitution in which no  amino acids change is called 

a)
Missense
b)
Nonsense
c)
Silent
d)
Deletion
18.

A nucleotide base is inserted or deleted shifting the entire DNA sequence. Entire protein will be changed.

a)

Substitution Mutation

b)

Silent Mutation

c)

Frameshift Mutation

d)

Translocation

19.
What causes mutations?
a)
Mistakes in replication or environmental substances
b)
The amino acids
c)
Passed down by genetics
d)
It's how your born
20.

Errors during DNA replication, repair or recombination can lead to base-pair

substitutions. Such changes are called ____________________

a)

A. conditional mutations.

b)

A. mutagens.

c)

spontaneous mutations

d)

A. saltatory changes.