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WorksheetsEx. 4-10
Total questions: 55
Worksheet time: 28mins
Name
Class
Date
1.
In limit test for chloride and sulphate in calcium gluconate, what is the wavelength used?
a)
265
b)
635
c)
480
d)
272
2.
Specific gravity of HCl
a)
1.18
b)
1.84
c)
36.45
d)
1.33
3.
Considered to be calcium salt of choice for intravenous use
a)
Calcium gluconate
b)
Calcium chloride
c)
Calcium sulphate
d)
Calcium glucose
4.
The precipitate formed when sodium chloride is mixed with silver nitrate
a)
Sodium nitrate
b)
Silver chloride
c)
Sodium bicarbonate
d)
Potassium nitrate
5.
Precipitate formed when sulphate is mixed with barium chloride
a)
Potassium chloride
b)
Barium nitrate
c)
Silver nitrate
d)
Barium sulphate
6.
Wavelength used in exercise 4 (determination of unknown concentration using UV-VIS spectrometer)
a)
265 nm
b)
635 nm
c)
480 nm
d)
272 nm
7.
Useful as QC test for conventional dosage form, excluding tablets intended to be chewed before swallowed and those designed to release the drug substance over a period of time.
a)
Dissolution
b)
Spectrophotometer
c)
Disintegration
d)
Hardness test
8.
FTIR components except
a)
Analyzer
b)
Radiation source
c)
Interferometer
d)
Detector
9.
FTIR usually scans the sample how many times for accuracy
a)
15 times
b)
14 times
c)
16 times
d)
17 times
10.
Characteristics of FTIR except
a)
have replaced dispersive spectrometers
b)
extended capabilities
c)
frequencies are not examined simultaneously
d)
superior sensitivity and speed
11.
Used in the assay of lithium carbonate
a)
FTIR
b)
Flame spectroscopy
c)
UV-Vis spectrometer
d)
NMR
12.
General specification for disintegration test
a)
30 minutes
b)
90 minutes
c)
60 minutes
d)
15 minutes
13.
Specifications for new formulation for friability test
a)
1%
b)
0.1%
c)
8%
d)
0.8%
14.
Total revolutions for tablet friability
a)
150 rev
b)
100 rev
c)
50 rev
d)
25 rev
15.
USP minimum tablet hardness
a)
1kg
b)
3kg
c)
4kg
d)
5kg
16.
Measures the diametrically applied force required to break the tablet that is produced by a manually operated air pump
a)
Stokes-Monsanto Hardness test
b)
Strong Cobb hardness tester
c)
Pfizer Hardness tester
d)
Erweka Hardness tester
17.
All are correct pair for acceptable range of tablet hardness, except:
a)
4 to 10 kg for ordinary compressed tablets
b)
4 kg for sublingual tablets
c)
2 kg for chewable tablets
d)
10 kg for buccal tablets
18.
Eliminates operator variability
a)
Stokes-Monsanto Hardness test
b)
Strong Cobb hardness tester
c)
Pfizer Hardness tester
d)
Schleuniger hardness tester
19.
Measurement of force required to break the tablet that is generated by coil spring that is applied diametrically to the tablet
a)
Stokes-Monsanto Hardness test
b)
Strong Cobb hardness tester
c)
Pfizer Hardness tester
d)
Schleuniger hardness tester
20.
It is 1.6 times better than Stokes
a)
Stokes-Monsanto Hardness test
b)
Strong Cobb hardness tester
c)
Pfizer Hardness tester
d)
Schleuniger hardness tester
21.
Resistance of the tablet to chipping, abrasion, or breakage under conditions of storage, transportation and handling
a)
Disintegration
b)
Dissolution
c)
Friability
d)
Hardness
22.
Evaluates the ability of tablets to withstand abrasion during packaging, handling and shipping
a)
Disintegration
b)
Dissolution
c)
Friability
d)
Hardness
23.
Determines the percentage loss on tablet in packaging, handling, and shipping
a)
Disintegration
b)
Dissolution
c)
Friability
d)
Hardness
24.
Number of samples used in hardness test
a)
3 samples
b)
6 samples
c)
10 samples
d)
20 samples
25.
Specified number of samples in friability test for a tablet weighing 0.7 grams
a)
3 samples
b)
6 samples
c)
10 samples
d)
20 samples
26.
Sieve number used on friability test
a)
#10
b)
#15
c)
#20
d)
#30
27.
Friabilator with no partitions in the middle
a)
Roche
b)
Vanke
c)
Abrasion
d)
Nonpartition
28.
Compulsory to new products in new market packages to ensure resistance of tablet to chipping, abrasion, or breakage under conditions of storage, transporation and handling
a)
Disintegration
b)
Thickness
c)
Friability
d)
Shipping Test
29.
Criteria for average thickness
a)
+- 3%
b)
+- 5%
c)
+- 10%
d)
+_15%
30.
Refers to depth or extent from one surface to another surface
a)
Diameter
b)
Thickness
c)
Friability
d)
Hardness
31.
Disintegration media is maintained at temperature of
a)
35+- 5 C
b)
37+- 0.5 C
c)
37 +- 2 C
d)
37+-5 C
32.
pH of simulated gastric fluid
a)
1.0
b)
1.2
c)
1.5
d)
2.0
33.
pH of simulated intestinal fluid TS
a)
7.0
b)
7.2
c)
7.5
d)
7.8
34.
Reagents used in preparing simulated gastric fluid except
a)
HCl
b)
potassium phosphate
c)
sodium chloride
d)
pepsin
35.
Reagents used in preparing simulated gastric fluid except
a)
pepsin
b)
potassium phosphate
c)
sodium chloride
d)
pancreatin
36.
If 3 tablets fail the disintegration test
a)
Accept
b)
test using additional 6 tablets
c)
test using additional 12 tablets
d)
Reject
37.
If only one tablet fail the disintegration test
a)
Accept
b)
test using additional 6 tablets
c)
test using additional 12 tablets
d)
Reject
38.
Number of tablets tested for disintegration test
a)
5
b)
6
c)
10
d)
12
39.
Number of tablets tested for friability test
a)
5
b)
6
c)
10
d)
20
40.
FTIR must be purged first with ____ to remove traces of carbon dioxide
a)
Nitrogen gas
b)
Lithium
c)
Methanol
d)
Ethanol
41.
Purging is done for
a)
5 to 10 min
b)
30 min to 1 hr
c)
1 to 2 hrs
d)
10 to 30 min
42.
It is the measurement of the absorption of light by free metallic atoms
a)
UV-VIS spectrophotometer
b)
AAS
c)
AES
d)
FTIR
43.
For detecting small amounts of an element when concentrations are too small to be measured accurately.
a)
UV-VIS spectrophotometer
b)
AAS
c)
AES
d)
FTIR
44.
Component of AAS where sample is introduced
a)
Burner
b)
Monochromator
c)
Detector
d)
Analyzer
45.
Component of AAS that blocks the light of wavelength different from the desired resonance lines from reaching the detector
a)
Burner
b)
Monochromator
c)
Detector
d)
Analyzer
46.
Matrix materials for pellet making in FTIR except
a)
KBr
b)
AgCl
c)
Csl
d)
NaCl
47.
Most widely used region with molecular vibration typically involved in organic molecules, it provides a wealth of structural information as well as quantitative data
a)
Near IR
b)
Mid IR
c)
Far IR
48.
Principally concerned with rotational spectral and crystal lattice vibrations
a)
Near IR
b)
Mid IR
c)
Far IR
49.
A region that gives a spectrum of the functional groups found in organic compounds
a)
Skeletal Vibrations
b)
Group vibrations
c)
Stretching vibrations
d)
Rotational vibrations
50.
A region that gives a spectrum and identification of the molecule as a whole
a)
Skeletal Vibrations
b)
Group vibrations
c)
Stretching vibrations
d)
Rotational vibrations
51.
Which of the following is not true about water in IR
a)
Water is used as solvent in IR
b)
It strongly absorbs most of the IR radiation
c)
It would destroy the sodium chloride cells which hold the sample
52.
Which of the following is true
a)
Mull technique is more expensive compared to KBr pellets
b)
Nujol and Fluorolobe are mulling agents
c)
KBr pellet is a general sample handling technique useful with samples that undergo ion exchange
53.
Commonly used for the analysis of certain trace elements in aqueous samples and other liquid samples.
a)
UV-VIS spectrophotometer
b)
AAS
c)
AES
d)
FTIR
54.
This method can solve any thickness problem in IR sampling
a)
Transmission technique
b)
Reflectance technique
c)
DRIFTS
d)
ATR
55.
Applicable to examine polymer samples and semi-solid samples
a)
Transmission technique
b)
Reflectance technique
c)
DRIFTS
d)
ATR
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