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WorksheetsAnaesthetic Agents
Total questions: 10
Worksheet time: 20mins
Local anaesthetic action
is usually very acidic and requires bicarbonate to activate it.
is dependent on metabolism to an active compound.
requires binding at the extracellular surface.
requires that agents have both lipophilicity and hydrophilicity.
results from agents that maintain nerves in the depolarized state.
Which of the following statements is best regarding allergic responses to local anaesthetic agents?
Allergic responses occur after administration of amides
Allergic responses occur after administration of esters
It is the metabolite of the amide structure that confers allergic response
The metabolite of the ester is responsible for allergic responses
The halogenated compounds have high allergic responses
Which statement about the speed of onset of nerve blockade with local anaesthetic is the most correct?
Faster in onset in infected tissues
Faster in onset in myelinated fibres
Faster in onset in hypocalcaemia
Slower in onset in hyperkalaemia
Slower in onset in the periphery of a nerve bundle than in the centre of a bundle
Which of the following statement about the toxicity of local anesthetic is the most correct?
Serious cardiovascular reactions are more likely to occur with tetracaine than with bupivacaine.
Cyanosis occurs after injection of large doses of lidocaine, especially in patients with pulmonary disease.
IV injection of local anaesthetics stimulates etopic cardiac pacemaker activity.
In overdosage, hyperventilation (with oxygen) is helpful to correct acidosis and lower extracellular potassium.
Most local anaesthetics cause vasoconstriction.
A 24-year-old woman was given an epidural anaesthetic for pain relief during labour. The drug selected had a slow onset, but a longer duration of action than most of the other local anaesthetics. Unfortunately, some of the drug was inadvertently IV injected and caused a marked drop in blood pressure and arrhythmia. The drug used was most likely
benzocaine.
bupivacaine.
cocaine.
lidocaine.
procaine.
The pharmacodynamics mechanism of action of general anaesthesia agent is most likely related to
depression of spontaneous and evoked neuronal activity.
hypopolarization of neurotransmitter-gated ion channels.
increased duration of opening of nicotinic receptor-activated cation channels.
inhibition of GABA receptor chloride ion channels.
their oil:water partition coefficient.
A 36-year-old man with a history of seizures is scheduled to undergo a complicated oral surgery? You are asked to select a general anaesthestic agent for the surgical event. The most appropriate choice is
enflurane.
nitrous oxide.
propofol.
sevoflurane.
thiopental.
The anaesthetic agent halothane
decreases catecholamine-induced arrythmias.
depresses the heart rate during anaesthesia.
has an irritant effect on the trachea-bronchial tree.
reduces stroke volume of the heart and decreases systemic blood pressure.
stimulates the sympathetic nervous system.
In the clinical use of general anaesthetic agents
chloroform is a stable agent for cardiovascular surgery.
diethyl ether is still highly regarded and widely used.
methoxyflurane is reserved for a long anaesthestic procedures.
nitrous oxide is widely used because of its low toxicity and high potency.
the concept of “balanced anaesthesia” is usually employed.
The most appropriate agent for a patient with minimal circulatory reserve is
diazepam.
halothane.
morphine.
nitrous oxide.
propofol.
