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WorksheetsPharmacokinetics
Total questions: 20
Worksheet time: 11mins
ABSORPTION: Absorption refers to the amount of drug that enters the ____________
bloodstream
liver
pancreas
target tissue
ABSORPTION: If 30% of a drug loses it's efficacy, the Bioavailability will be ___________
negative
70%
30%
15%
Alternative routes of administration like suppository, intravenous, intramuscular, inhalational aerosol, transdermal and sublingual avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.
True
False
ABSORPTION: Intravenous drugs have __________ bioavailability.
zero
50%
full
100%
ABSORPTION: _________ is an example of an antibiotic that is normally used IV to treat serious infections because it is so poorly absorbed orally.
vancomycin
clindamycin
azithromycin
gentamycin
DISTRIBUTION: One class of drugs that we discussed that requires therapy management for appropriate measurements includes:
topical agents
aerosol inhalers
seizure meds
antidepressants
DISTRIBUTION: A drug bound to a protein is _____________
active
mobile
free
inactive
DISTRIBUTION: ___________is the main protein that binds medications in the blood.
albumin
thrombin
insulin
oxytocin
DISTRIBUTION: Medications with a large volume of distribution generally have a ___________ blood concentration.
larger
lower
similar
stable
DISTRIBUTION: Most medications require a loading dose TRUE or FALSE
True
FALSE
METABOLISM: The metabolism of medication is the _______ ______ ________ in the body
elimination of medication
production of enzymes
breakdown of medication
altered chemical reaction
METABOLISM: Metabolites are the altered chemical forms of the drug. TRUE or FALSE
true
false
METABOLISM: CYP enzymes are very active in converting a drug to it's ___________.
protein
onset
molecule
metabolite
METABOLISM: Which of the following is a disadvantage of a long acting metabolite
wider distribution
prolonged side effects
prolonged effect
decreased metabolism
METABOLISM: A drug administered in an inactive form is called a(n) __________
enzyme
altered drug
pro drug
metabolite
EXCRETION: ____________ refers to the removal of a drug from the body, mainly in the urine or feces.
metabolism
distribution
transfer
elimination
EXCRETION: The correct term to indicate "half life" is:
T 1/2
1/2 H
HL
1/2 T
EXCRETION: Half life refers to the time it takes for 50% of a drug to be _____________.
metabolized
eliminated
cleared
induced
EXCRETION: A drug with low clearance will typically have a __________ half life.
typical
altered
long
shortened
EXCRETION: The most common location of drug excretion in the body is the __________.
liver
small intestines
large intestines
kidneys
