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WorksheetsImmunology
Total questions: 26
Worksheet time: 13mins
Which of the following is primary lymphoid tissue?
Thyroid making T cells
MALT
Bone marrow making B cells
Lymph nodes engaging pathogen
What is the first immunoglobulin heavy chain synthesized during the maturation of a B lymphocyte?
Alpha chain
Epsilon chain
Gamma chain
Mu chain
What best describes Th2 T Cells?
Activated by binding entire antigen by BCR
IL-4 is a signature cytokine
Primary target cell is neutrophil
Promotes class switch from IgM to IgG
Which statement best describes activation-induced cytidine deaminase (AICDA or AID)?
Induced by CD40L-CD40 signals
Converts adenine to guanine
Part of T cell positive selection
Part of B cell negative selection
What is the Complement system component from innate immunity that promotes adaptive immune cell activation?
C5a binding TCR of T cells
C3a binding TH17 cells
C3d binding CR2 of B cells
C1qrs binding TdT of T cells
What cell is the major source of interleukin-2?
Naive B cells
+ T cells
Overly aggressive NK cells
Really angry macrophages
Which cell releases histamine during acute inflammation?
neutrophils
eosinophils
platelets
mast cells
Which Complement component deficiency leads to increased incidence of systemic lupus erythematosus (SLE)?
D
C2
C3
C5
Which statement best describes the T cell antigen receptor (TCR)?
Signaling through Iga and Igb proteins
Binds conformational lipid/sugar epitopes
Recognizes only peptide/MHC complex
Active form membrane-bound IgM/IgD
Which statement describes a function of antigen-presenting cells (APC)?
Neutrophil/Effector phase of cell-mediated immune response
Macrophage/Initiation of NK cell response to parasites in innate immunity
B cell/Protein antigen presented to CD4 helper T cells in humoral immunity
Asplenic patient has increased risk of infection from which organism?
spore-forming bacteria
fungal infections
intracellular pathogens
encapsulated bacteria
What is Omenn Syndrome?
elevated T cell numbers
increased IgE and eosinophils
adenosine deaminase deficiency
decreased macrophages
What is the degree of cellular sensitivity to ionizing radiation (from most sensitive to least sensitive?
B cells > T cells > macrophage
Macrophage > T cells > B cells
T cells > Macrophage > B cells
Which statement best describes transient hypogammaglobulinema of infancy?
lack specific Ab made against vaccines
is decreased CD3 cells
recurrent sinopulmonary infections
enhanced T cell function
Which is a HIV capsid protein?
p24
gp120
Nef
LTR
Which statement best describes zidovudine (AZT = ZDV) ?
Protease inhibitor
Integrase inhibitor
Non-nucleoside reverse transcriptase inhibitor
Nucleoside reverse transcriptase inhibitor
What is the middle name of Frank C. Church and what is the middle initial of Tom Belhorn, respectively
Charles and he has no middle initial
Joshua and X.
Clement and H.
When a rabid bat bites Dr. Church, he should receive what therapy?
Rabies Ig plus vaccine
vaccine alone
tetanus vaccine alone
anti-bat IgG + garlic
A 15 month old, HIV+, CD4 count <20 can safely get vaccine with what vaccine?
Diphtheria
Measles
Varicella (chicken pox)
Live influenza
Which of the following innate immune cells are phagocytic (select all that apply)?
Macrophage
Dendritic cell
Neutrophil
Mast cell
Endothelial cell
Which of the following best pairs an innate immune Toll-like receptor (TLR) with its function?
A. Toll-like receptor (TLR); recognition of foreign extracellular proteins to initiate an inflammatory cascade
Toll-like receptor (TLR); recognition of pathogen-associated molecular patterns to elicit an immune response
Toll-like receptor (TLR); recognition of specific antigens through self/non-self discrimination
Which of the following innate immune cells would best obliterate a viral infection?
Neutrophil
Natural killer cell
Eosinophil
Basophil
TRUE or FALSE: The adaptive immune system provides a delayed and pathogen-specific response to infection.
True
False
Oh wow, true/false questions can be tough, trying to read the prof's mind!
TRUE or FALSE: CD4+ T cells recognize peptide/MHC I, while CD8+ T cells recognize peptide/MHC II.
True
False
What a mean prof.; just don't like T/F
Which of the following enzyme complexes is formed by all three pathways for Complement activation?
C1 convertase
C2 convertase
C3 convertase
C4 convertase
Which of the three complement pathways is directly associated with the adaptive immune system?
Alternative
Classical
Lectin
