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Immunomodulators/suppressants

Total questions: 13

Worksheet time: 13mins

Name
Class
Date
1.

This drug binds to the IL-5 receptor and inhibits cell activation

a)

Rituximab

b)

Benralizumab

c)

Omalizumab

d)

Mepolizumab

2.

This drug is a JAK/STAT inhibitor

a)

Azathioprine

b)

Sirolimus

c)

Tofacitnib

d)

Etanercept

3.

Which of these drugs does not bind and inhibit Tumor necrosis factor

a)

Tocilizumab

b)

Etanercept

c)

Infliximab

d)

Adalimumab

4.

Which of these drugs binds to IgE on B-cells?

a)

Tiruximab

b)

Omalizumab

c)

Benralizumab

d)

Anakinra

5.

Basiliximab has what function?

a)

Binds to the IL-6 receptor

b)

Binds to the IL-1 receptor

c)

Binds to the IL-2 receptor

d)

Binds to the IL-5 antibody

6.

Sirolimus has what function?

a)

Inhibits calcinuerin

b)

inhibits JAK/STAT

c)

Inhibits Purine synthesis

d)

Inhibits mTOR

7.

Where does Tocilizumab bind?

a)

Directly to IL-6

b)

To the IL-6 Receptor

c)

Directly to IL-5

d)

To the IL-5 Receptor

8.

Which of these drug classes can lead to Non-hodgkins lymphoma?

a)

Calcinuerin inhibitors

b)

Corticosteroids

c)

JAK/STAT Inhibitors

d)

mTOR inhibitors

9.

Which of these drugs may be responsible in producing Reye's syndrome?

a)

Montelukast

b)

Aspirin

c)

Cyclosporin

d)

Tofacitinib

10.

Which of these are consitutively expressed?

a)

COX-1

b)

COX-2

11.

Corticosteroids decrease transcription for genes regarding all of the following except

a)

IL-2

b)

IL-6

c)

TNF

d)

IL-10

12.

Which of these drugs inhibits Inosine Monophosphate Dehydrogenase

a)

Methotrexate

b)

Tofacitinib

c)

Mycophenolate

d)

Cyclosporin

13.

Which of these can lead to mutagenicity (i.e. Acute myeloid leukemia, lung adenocarinoma)

a)

Azathioprine

b)

Mycophenolate

c)

Montelukast

d)

Sirolimus