Font size
WorksheetsDOSAGE FORM (Part1)
Total questions: 100
Worksheet time: 12hrs 26mins
A product designed for administration to the body in the diagnosis or treatment of disease is called
Drug
Injection
Dosage Form
Resins
A device that holds a drug and may be in direct contact with the drug
Insert
Container
Labels
Transdermal Drug Delivery
A container that protects the contents from extraneous solids and from loss of article under ordinary conditions of handling and shipment storage and distribution
Tightly Closed Container
Hermetic Container
Well Closed Container
All
What type of packaging is not easily tampered
Tape Seal
Bubble Pack
Blister Pack
Aerosol
According to the USP, the instruction “protect from light” in a monograph indicates storage in a
Light Resistant Container
Dark Place
Amber Glass Bottle
Hermetic Container
1. Single dose parenteral container
I. Permits withdrawal of successive portions of the content
II. Ampule
III. Is a hermetic container
I and III
II and III
I and II
I,II,III
The USP limits the size of single dose containers to
30mL
50mL
1000mL
100mL
According to USP Standards , a refrigerated can be used to store pharmaceutical that specify storage in a
Cool Place
Cold Place
Freezer
Room Temp
Based on USP guidelines the stability of extemporaneous compounded aqueous liquids (reconstituted formulation) is
Beyond use date of not later than 25% of the time remaining until the products’ expiration date or 6 months whichever is earlier
Not less than the intended duration of therapy or 30 days whichever is earlier
Not later than 14 days when stored at cold temperature
A. Maximum beyond use date use 6 months or 25% of the remaining time between the compounding date and then the shortest expiration date of the ingredients whichever is earlier
The expiry date on a pharmaceutical container states “expires Jul 20-17”. This statement means that by the expiry date, the product may have lost
Up to 5% of its activity
Up to 10% of its activity
Up to 50% of its activity
Sufficient activity to be outside USP Monograph requirements
The following are examples of single-dose parenteral containers EXCEPT
Fusion-Sealed Ampules
Pre-filles syringe
30mL-capacity vials
Cartridges
Photodegradation can be prevented by packaging drugs in a light resistant container. Which of the following containers is light resistant
I.Colorless bottle covered with aluminum foil
II.Plastic Bottle
III.Amber colored bottle
IV.Bottle covered with carbon paper
I,II,III
II,III,IV
I,III,IV
I,II,III,IV
The following route of administration will provide the highest concentration of drugs in the blood
Intavascular
Intradermal
Intramuscular
Oral
Type II glass container is
Highly resistant borosilicate glass
Treated soda lime glass
Soda lime glass
General purpose soda lime glass
It is used to mask the bitter taste of the product
Cacao
Fruits or Citrus Fruits
Cinnamon, Orange and Raspberry
All
The disadvantage of Sodium Saccharin as a sweetening agent is
Contraindicated with phenylketonurics
Bitter after taste
It has a carcinogenic potential
130X as sweet as sucrose
Which is TRUE: FD&C yellow#5
Can cause allergic reaction to patient allergy to penicillin
Known to be Tartrazine
It is permitted to used externally
All
In preparing lipstick which type of colorant should be used
External D and C
F D and C
D and C
All
The following are frequently used as ophthalmic preservatives EXCEPT
Benzalkonium chloride
Chlorobutanol
Phenylmercuric nitrate
Propylparaben
100% proof alcohol is
50% ethyl alcohol
Absolute alcohon
50% methyl alcohol
100% ethyl alcohol
The term “impalpable” refers to a substances that is
Colorless
Greasy
Tasteless
Not perceptible to touch
1. An approach to stabilize preparation against hydrolytic decomposition;
I. Removal of water
II.Use of antioxidant
III. Use of buffering agent
IV. Supplying the drug in dry form for reconstitution
I,II and IV
I,II and III
I,III and IV
II, III and IV
1. Which of the following is an antioxidant?
A. Alpha-tocopherol
B. Butylhydroxyanisole
C. Ascorbic Acid
D.Sodium bisulfite
ABC
ACD
BCD
ABCD
Which of the following is an example of oxidant of an organic, active drug molecule?
Decrease in valence of the drug molecule
Gain electron(s) by the drug molecule
Addition of hydrogen to a carbon-carbon double bond
Loss of hydrogen from alcohol hydroxyl group
The major ingredients in most dosage forms of aqueous solution is
Water
Aromatic Water
Alcohol
Acidulated Water
Dosage forms employed to combat infection
Vaginal suppository
Vaginal tablet
Oral tablet
All
When incorporating potent substances in powder, the process used is
Block and divide method
Geometric dilution
Levigation
Pulverization by intervention
The most accurate method of extemporaneously preparing divided powders although time consuming
Weighing to individual doses
Block and Dividing
Estimation
All of these
Particle terminology is essential in the formulation and manufacture of:
Powders
Aerosols
Capsules
All
Combinations of mixtures of drugs which liquefy due to a lowering of their melting point
Deliquescent
Hygroscopic
Efflorescent
Eutectic Mixture
1. Hygroscopic and deliquescent substances may be incorporated in to powders by:
A. Addition of lubricant
B. Double wrapping
C. Addition of diluents
A and C
A and B
B and C
All
A waterproof paper that is commonly used to wrap hygroscopic and deliquescent materials
Vegetable Parchment
Wax paper
Glassine paper
Bond paper
The process of grinding a drug in a mortar to reduce the particle size is termed:
Tumbling
Trituration
Spatulation
Levigation
What are the main ingredients of effervescent granules:
Sodium carbonate, citric acid and tartaric acid
Sodium bicarbonate, citric acid , tartaric acid
Sodium carbonate , ascorbic acid and sodium tartrate
Sodium bicarbonate, ascorbic acid and tartaric acid
1. The following are true about granules ;
A. More stable physically and chemically than are the corresponding powders from which they were prepared
B. More easily “wetted” by a solvent than a certain powder
C. More likely to cake or harden upon standing that powders
D. Their surface area is less than of a powders
A,B and D
A,B and C
B,C and D
All
1. In preparing effervescent salts, which of the following statement/s hold/s TRUE:
I. Effervescent granules can be prepared using two methods, the dry and the wet
II. The effervescent from the released CO2 serves to mask the bitter or salty taste of the drug
III. Using tartaric acid as the sole acid would result in a sticky mixture which is difficult to granulate
I and II
II and III
I and III
I,II and III
Efflorescent powders when triturated or stored in low humidity releases
CO2
Dust
Water
Good Smell
A very fine powdered chemical is defined as one that will;
Completely pass through a #40 sieve and not more 40% through a #80 sieve
Completely pass through a #20 sieve and not more than 40% through a #60 sieve
Completely pass through #8 sieve and not more than 20% through sieve no. 60.
Completely pass through a #80 sieve no limit to greater fineness
Finely divided powders introduced into body cavity such as vagina, ears, nose, throat are
Douche Powder
Dusting
Insufflations
Triturations
The following are appropriate actions when dispensing bulk medicated powders ;
A. Mixing oral powders with a liquid for administration
B. Inclusion of potent or low dosage active drug
C. Inclusion of antimicrobial drugs in topical preparations
D. Provision of supplemental device to measure the dosage amount
A, B and D
A, C and D
B, C and D
A, B, C and D
Ideal containers for dispensing dusting powders
Sifter top container
Wide mouth bottles
Paste board boxes
Amber colored bottles
Products for external uses
White colored label
Any color as long as the statement “For External Use Only”
Red Colored Label
Any will do gusto mo yon?
Which pharmaceutical ingredient can be included in powders used to manufacture hard gelatin capsules that contain magnesium stearate as glidant?
Sodium lauryl sulfate
Pregelatized starch
Silicon dioxide
Croscarmellose
Which of the following capsule is the largest
1
5
0
00
Added to make capsule opaque
Calcium oxide
Salol
Titanium dioxide
Silicon dioxide
The primary composition materials od capsule shells
Gelatin
Agar
Acacia
Tragacanth
What substances are added to render soft gelatin capsule elastic or plastic like
Glycerin
Gelatin
Mineral oil
Sorbitol
1. The main difference between hard and soft gelatin capsules is/are:
Dyes are added to the capsule shell
Hard gelatin shells are not plastiziced
Hard gelatin capsules are plasticized
All of these !
Hard gelatin capsules are;
In small scale compounding, pharmacist uses “punch” method
Contain preservatives like parabens
Commonly employed in clinical trials
Soft gelatin capsules are;
In small scale compounding, pharmacist uses “punch” method
Are used to hermetically seal and encapsulated liquids, suspensions and pasty materials
Contain more moisture than hard gelatin capsule
It can be prepared by rotary die process
The ideal excipient for the preparation of chewable tablets containing moisture sensitive drug
Lactulose
Saccharin Sodium
Xylitol
Dextrose
Mannitol
The following are used tablet formulation to reduce friction during tablet compression
Calcium stearate
Magnesium stearate
Stearic acid
Mineral Oil
All
Lubricants contribute to the preparation of compressed tablets by: EXCEPT!
Improving the flow of the granulation
Prevent adhesion of the tablet formulation to the punches dies during compression
Reduce friction
Give a sheen to the finished products
None
All of the following impart satisfactory compression characteristic to the formulation of the tablet EXCEPT;
Sweetening agents
Binder
Diluents
Lubricants
TRUE statement about the function of excipients used in tablet formulation EXCEPT;
Binder promote granulation
Lubricants help the patient to swallow the tablet
Glidants promote the flow of the tablet granulation
Diluents make up the desired bulk of the tablet formulation
The principal factor that makes enteric coated tablets unpredictable in drug therapy is
Premature in release of the drug
Varying thickness of the drug
Failure to release the drug
State of the health of the patient
Which of the following is used as a binder for tablet
Starch
Liquid Glucose
Talc
Gelatin
Any substance combined with an active ingredients to make letter agreeable to convenient dosage is called:
Diluent
Lubricant
Disintegrator
Excipients
Type of tablet coating where the first coat in shellac is
Enteric coating
Micro-coating
Film coating
Sugar coating
It is a common lubricant for tablets
Mannitol
Acacia
Starch
Magnesium stearate
Formulation methods of achieving sustained drug release include
Use of coating
Microencapsulation
Embedding the drug in a matrix
Drugs that are destroyed by gastric acid or that irritate the gastric mucosa are usually formulated
External preparation
Enteric coated tablets
Capsules
Chewable tablet
This is used as binder, diluents and disintegrant for tablet
Magnesium stearate
Talc
Starch
Kaolin
Tablet dosage form not requiring disintegration
Enteric coated
Film coated
Sustained release
Chewable
Type of coating for tablets consisting of thin of water insoluble polymeric substances is
Film coated
Sugar coated
Enteric coated
Chocolate coated
The following are characteristics of pills
Adhesive
Chewable
Plasticity property
Firm
Unit-dose packaging for tablets or capsules is exemplified by;
I. Strip packaging
II. Wide-mouthed bottles
III. Blister pack
Only I
I and II
II and III
I and III
1. Flavoring agents are usually added to:
I. Buccal tablets
II. Film-coated tablets
III. Chewable tablets
I, II and III are correct
I and III are correct
I and II are correct
II and III are correct
Uncoated , bullet- or ovoid- shaped tablets intended for localized effect;
Vaginal tablet
Sugar-coated tablet
Effervescent tablet
Multiple Compressed tablet
Which method of tablet manufacture can be used to combine two incompatible substances in the same tablet:
Sugarcoating
Multilayer compression
Film coating
Enteric coating
To protect drugs from decomposition from moisture, tablets are co-packaged with:
Cotton wool
Aluminum foil
Fumed silica
Dessicant package
Which of the following factors does influence the speed of drug dissolution from tablets?
Tablet hardness
Particle size of the drug
Solubility of the drug
Weight Uniformity
Which of the following tablet dosage forms avoids the hepatic first pass effect?
Enteric coated
Sublingual
Chewable
Instantly disintegrating
Increase amount of this capsule/tablets excipient reduces wetting of particles thus slowing dissolution
Surface active agents
Disintegrant
Lubricant
Diluent
Lozenges usually do not contain the following tableting excipients
Cross linked povidone
Sucrose
Lactose
Gelatin
To what type of modified release formulation enteric coated tablet belongs?
Controlled release
Delayed-action
Sustained-action
Extended- action
Advantages of controlled release drug dosage forms are:
Decrease patient compliance
Extended daytime and night activity of the drug
Reduced incidience of side effects
Increased dosage frequency
Methods utilized to achieve controlled drug release from solid dosage forms
Coated beads or granules
Complex formation
Ion exchange resist
This type of dosage form allows a reduction in dosing frequency to that presented by a conventional dosage
Extended-release
Repeat Action
Targeted release
Delayed-release
Which of the following statements hold true for extended-release dosage forms
There is frequency reduction in dosing
There is reduction in drug blood level fluctuation
There is reduction in terms of adverse effects.
Microencapsulation is;
A process by which solids, liquids, or even gases maybe encapsulated int microscopic size
The technology employed in Micro-K Extencaps
Formed by applying thin coating of “wall” material around the substance being encapsulated
The most common “wall” forming material used in microencapsulation is;
Lactose
Dextrose
Gelatin
Sorbitol
Correct statements about repeat-action tablets includes;
The tablet may be prepared with immediate-release dose in the tablet's outer shell
The tablet’s second dose in the inner core
An example of this type of product is the GITS(Gastrointestinal Therapeutic System)
In preparing extended-release product by embedding drug in inert plastic matrix includes;
The granulated drug is compressed into tablet
The drug is granulated with an inert plastic material such as hydroxypropylmethylcellulose
The inert tablet matrix, expended of drug, is excreted with the feces
In ion-exchange resin technology of extended-release formulations, the release of the drug from the complex is;
Dependent upon the pH of the GIT
Dependent upon the electrolyte
Both are correct
Both are wrong
Implants are;
Inserted under the skin by special injector or by surgical incisions
Examples of transdermal drug delivery system
Designed to provide long-term drug therapy through the slow release of medication
A TDDS used to prevent travel related motion sickness is;
Transdermal nicotine
Transdermal scopolamine
Transdermal clonidine
Transdermal estradiol
1. Transdermal Drug delivery System (TDDS);
I. Facilitate the passage of therapeutic quantities of drug substances through the skin into the systemic circulation
II. often called “transdermal patches”
III. Avoid first-pass effect
Only I is correct
I and II are correct
II and III are correct
All are TAMA !
Advantages of Transdermal Drug Delivery System include:
Avoids the occurrence of contact dermatitis
Avoids GI drug absorption incompatibilities
Drug therapy cannot be terminated rapidly
All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT;
Molecular weight of 100 to 400
A high partition coefficient of the drug
Full hydration
High aqueous solubility of the drug
Which of the following polymers in a membrane ingredient in several TDDS products?
Glyceryl polymethacrylate
Ethylene-vinyl acetate
Polyvinyl chloride
Cellulose acetate phthalate
Substances that increase percutaneous absorption
Dimethyl sulfoxide
Olive oil
Agar
Nonoxynol 9
Percutaneous absorption in TDDS increases with
(MARAMI ANG SAGOT)
Amount of drug
Amount of rubbing
Surface area
The part of the transdermal drug delivery system which controls the release of the drug is the
Adhesive paper
Protective peel strip
Drug reservoir
Microporous membrane
The following are example of oleaginous bases EXCEPT;
Lanolin
Yellow Ointment
Petrolatum USP
None
Medicated or non-medicated semisolid preparation intended for external application
Lotion
Liniment
Ointment
All
Package for ointments and other semisolid preparations.
Large-mouth jars
Metal tubes
Plastic tubes
Well-closed container
These are solid or semi-solid adhesive masses spread upon a backing material of paper fabric, moleskin or plastic.
Creams
Plasters
Lotion
Paste
A viscous preparation intended for warm, external application to a body surface is;
Glycerite
Ointment
Poultice
Glycerogelatin
How many percent of ZnO is contained in Zinc Glycerogelatin
15%
35%
45%
10%
