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WorksheetsAntimicrobials & Resistance
Total questions: 60
Worksheet time: 30mins
When two drugs are given simultaneously and work better together:
commensalism
antagonism
synergism
symbiosis
When two drugs are given simultaneously and inhibit one another:
commensalism
antagonism
synergism
symbiosis
Antibiotics that target bacterial translation denature the:
nucleus
70s ribosome
80s ribosome
nucleoid
Microbes with genetic characteristics allowing for their survival when exposed to an antibiotic are called ______________________
persister cells
alterations
super-infections
transducers
Which of the following is easiest to treat with antimicrobial agents:
fungi
bacteria
protists
viruses
According to the chemotherapeutic index, the larger the number, the safer the drug
True
False
_________________________ is the ability of the body to ward off disease using physical and chemical factors, including secretions and antimicrobials.
autoimmunity
resistance
selective toxicity
hypersensitivity
Sometimes, drugs are combined to target different areas of the microbe.
True
False
Gram negative organisms are more resistant to control agents than Gram positive.
True
False
_________________________ is a set of undesirable reactions produced by the normal immune system, including drug allergies and autoimmunity.
selective toxicity
hypersensitivity
allergies
resistance
Which of the following is not an example of antibiotic misuse?
using antibiotics in animal feed
using outdated antibiotics
finishing a full prescription of antibiotics
prescribing antibiotics for viruses
There are selectively toxic drugs for prion treatment.
True
False
One disadvantage of using broad spectrum antibiotics is that they:
target host cells
destroy normal microbiota
are easily inactivated by the host
are extremely toxic
Gram-negative bacteria are relatively more resistant to antibiotics because:
they are too small for the antibiotic to attack.
their cell wall restricts absorption of molecules through porins.
they all have capsules that resist antibiotics.
they secrete antibiotic-destroying compounds.
If you measure a large zone of inhibition in a disk-diffusion test, one can assume that the bacteria are:
Producing the antibiotic
Sensitive to the antibiotic
Unaffected by the antibiotic
Resistant to the antibiotic
If you measure no zone of inhibition in a disk-diffusion test, one can assume that the bacteria are:
Producing the antibiotic
Sensitive to the antibiotic
Unaffected by the antibiotic
Resistant to the antibiotic
An antibiotic that attacks the LPS layer would be expected to have a narrow spectrum of activity.
True
False
An antibiotic that attacks both G+ and G- cells would be expected to have a narrow spectrum of activity.
True
False
In what way are semisynthetic penicillins and natural penicillins alike?
Both are bactericidal.
Both are broad spectrum.
Both are resistant to penicillinase.
Both are based on β-lactam rings.
In the ____________________ method, filter paper disks are soaked in a chemical and placed on a culture to evaluate the efficacy of chemical agents.
Use-Dilution
Disk-Diffusion
Kinyoun
Ehrlich
Which of the following antimicrobials has the broadest spectrum of activity?
streptomycin
isoniazid
penicillin
tetracycline
A “fake nucleotide” that acts as a DNA/RNA inhibitor:
faucleotide
cytosine dimer
nucleoside analog
thymine dimer
The ability of antibiotics to target specific microbial structures without harming the host is termed _________________________.
Anaphylaxis
Selective toxicity
Hypersensitivity
Resistance
________________, ________________, and _______________ are the main components in topical ointments like Neosporin.
bacitracin, neomycin, polymyxin-B
bacitracin, neomycin, imidizole
peuromutilins, neomycin, polymyxin-B
tetracycline, neomycin, pleuromutilins
The formation of hives is considered a ___________ reaction.
resistance
hypersensitivity
Some Gram + bacteria contain an enzyme called _____________ that breaks down penicillin’s beta-lactam ring.
penicillinase
beta-lactamase
beta-galactosidase
both beta-lactamase & penicillinase
One effect of washing regularly with antibacterial agents is the removal of normal microbiota. This can result in:
increased susceptibility to disease
body odor
fewer diseases
overcolonization by normal microbes
The first penicillinase-resistant semisynthetic penicillin was:
methicillin
penicillin
cephalosporin
augmentin
In penicillin-reisistant G+ infections, what chemical is used as a noncompetitive inhibitor of penicillinase?
clavulanate
ampicillin
methicillin
penicillin
If a patient is allergic to penicillin, ___________ is prescribed.
cephalosporin
tetracycline
bacitracin
isoniazid
Topical treatment used against G+ bacteria.
bacitracin
polymyxin B
vancomycin
penicillin
Topical treatment used against G- bacteria.
bacitracin
polymyxin B
vancomycin
penicillin
Last line of defense against MRSA
vancomycin
methicillin
penicillin
cephalosporins
Danny has tuberculosis, which of the following would be the best treatment?
isoniazid
penicillin
vancimysin
augmentin
Inhibits folic acid synthesis:
sulfonamides
methicillin
isoniazid
amphotericin B
Antiretrovirals treat viruses that have:
betalactamase
betagalactosidase
reverse transcriptase
DNA polymerase
Which of the following target fungal cell walls?
amphotericin B
quinine
polymyxin B
penicillin
Treats malaria:
niclosamide
tetracycline
isoniazid
chlorocrine
Treats helminthic infections:
niclosamide
ergosterol
quinine
chloramphenical
Bacteria require resistance genes via _________ & __________.
mutation; HGT
mutation; VGT
VGT; HGT
None of these
Antibiotic resistance refers to a microbes ability to survive treatment by resisting the antibiotic.
True
False
Antibiotic resistance refers to a host's ability to survive treatment by resisting the antibiotic.
True
False
Natural, chemical, and synthetic drugs that combat disease in the body.
chemotherapeutic agents
antibiotics
prescriptions
persisters
Protein synthesis inhibitors like chloramphenicol target the:
cell wall
plasma membrane
70s ribosome
DNA
Some G+ cells treated with penicillin can survive without peptidoglycan.
True
False
Which of the following combinations would most likely contribute to the development of a superinfection?
short-term use of broad-spectrum antimicrobials
short-term use of narrow-spectrum antimicrobials
long-term use of broad-spectrum antimicrobials
long-term use of narrow-spectrum antimicrobials
Which of the following routes of administration would be appropriate for home administration to treat a systemic infection?
oral
intravenous
topical
parenteral
Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
treatment of a polymicrobial mixed infection in the intestine
prophylaxis against infection after a surgical procedure
treatment of strep throat caused by culture identified Streptococcus pyogenes
therapy of pneumonia while waiting for culture results
Narrow-spectrum antimicrobials are commonly used for prophylaxis following surgery.
True
False
Which of the following is not a type of β-lactam antimicrobial?
penicillins
methicillin
cephalosporins
ciprofloxacin
Which of the following does not bind to the 30S ribosomal subunit?
chloramphenicol
tetracycline
neomycin
tobramycin
Which of the following antimicrobials inhibits the activity of DNA gyrase?
ciprofloxacin
rifampin
clindamycin
polymyxin B
Which of the following is not an appropriate target for antifungal drugs?
β-glucan
chitin
ergosterol
cholesterol
Which of the following drug classes specifically inhibits neuron transmission in helminths?
chlorocrine
ivermectin
niclosamide
mebendazole
Which of the following is a nucleoside analog commonly used as a reverse transcriptase inhibitor in the treatment of HIV?
acyclovir
ribavirin
azidothymidine (AZT)
amantadine
Antiviral drugs, like _____ are neuraminidase inhibitors that prevent influenza virus escape from host cells.
Olsetamivir
Pleconaril
Amantadine
Simeprevir
Which of the following resistance mechanisms describes the function of β-lactamase?
target overproduction
drug inactivation
target mimicry
efflux pump
Which of the following resistance mechanisms is commonly effective against a wide range of antimicrobials in multiple classes?
target overproduction
target modification
target mimicry
efflux pump
In the Kirby-Bauer disk diffusion test, the _______ of the zone of inhibition is measured and used for interpretation.
depth
circumference
microbial population
diameter
If drug A produces a larger zone of inhibition than drug B on the Kirby-Bauer disk diffusion test, drug A should always be prescribed.
True
False
