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WorksheetsPathogenicity
Total questions: 60
Worksheet time: 30mins
According to Koch’s Postulates, in order to identify a specific pathogen, it must be present in every case of the disease.
True
False
Mobile elements in the cell wall of bacteria that carry virulence genes and are often shuffled/deleted:
Motility Bridges
Transposons
Pathogenicity Islands
HFR Elements
Jill stepped on a rusty nail and contracted tetanus, what route will the bacteria use to cause infection:
Urogenital
Parenteral
Gastrointestinal
Inhalation
In a biofilm, adhesins are used to form the bacterial ___________________, allowing adhesion and sharing of nutrients.
Spikes
Glycocalyx
Cell wall
Cell membrane
Gram positive and Gram negative bacteria both utilize __________________ as a method of adhesion.
Fimbriae
MSCRAMMS
Pili
Afimbriae
The process used by some microbes to force host cell endocytosis of the pathogen is termed:
Membrane ruffling
Forced-exocytosis
Siderophoration
Pinocytosis
Protein that is released by bacteria and pokes holes in host cell membranes.
Invasin
Coagulase
Cadherin
Perforin
The primary factors that contribute to microbial pathogenicity are __________________.
Toxins
Genes
Cell walls
Nutrient availability
Membrane disrupting toxins that lyse blood cells:
Leukocidins
Hemolysins
Streptolysins
All of these
Pyrogens cause:
Vomiting
Diarrhea
Fever
Itching
Ergot is a hallucinogenic toxin released by some:
Fungi
Prion
Virus
Bacteria
Cytopathic effects of viruses do not include:
Syncytium
Uncontrolled mitosis
Bacteriocins
Inclusion Bodies
Which of the following bacteria contain exotoxins:
Corynebacterium diptheriae
Clostridium tetanae
Clostridium botulinum
All of these
Which of the following bacteria contain endotoxins:
Clostridium botulinum
Salmonella typhimurium
Staphylococcus aureus
Streptococcus pyogenes
Allow the formation of blood clots:
Coagulases
Collagenase
Hyaluronidase
Kinases
Allow the digestion of blood clots:
Coagulases
Collagenase
Hyaluronidase
Kinases
Protozoates and helminths cause disease symptoms due to the buildup of _________________ in the host.
Worms
Phagocytosis
Wastes
Endotoxins
Which of the following are both portals of entry and exit.
Gastrointestinal tract
Mucus membranes
Skin
All of these
The ability to cause disease by overcoming host defenses is termed __________, whereas ____________ is the degree to which the pathogen overcomes host defenses.
pathogenicity; virulence
virulence; pathogenicity
In some cases, microbes process information by using cascades to regulate gene expression in response to environmental cues via __________________.
signal transduction
positive feedback
perspiration
immunity
The _____measures the potency of a microbe’s toxin, whereas the _____ measures a microbe’s overall virulence.
LD50; ID50
ID50; LD50
The _________________ is the period between the entry of the microbe and the appearance of disease symptoms.
prodromal
incubation
decline
illness
_______________are proteins secreted by pathogens that scavenge iron deposits from host cells.
MSCRAMMS
Siderophores
Fimbriae
Bacteriocins
Amoebocytes are cultured from __________________ and are used to test for the presence of endotoxins.
horseshoe crabs
cats
rabbits
goldfish
Microbiota can protect against infection by preventing pathogens from colonizing epithelial surfaces. This is:
colonization resistance
vaccinomics
pathogenicity
virulence
The likelihood of disease increases as the number of microbes decreases.
True
False
Which of the pathogens below are the most virulent:
Ebola virus
Rhinovirus
Chlamydia
Strep-Throat
Which of the pathogens below are the least virulent:
Ebola virus
Rabies virus
Vibrio cholerae
Rhinovirus
Most microbes are never pathogenic.
True
False
The shorter the incubation period, the more chance the microbe will be transmitted.
True
False
Diagnosis and effective treatment of infection depends on:
Recognized syndromes
Patient’s clinical condition (signs & symptoms)
Isolation and biochemical testing of potential pathogen
All of these
Stephanie has an enterohemorrhagic E. coli infection. What was the most likely portal of entry?
gastrointestinal
parenteral
respiratory
genitourinary
Which of the following is not a method of bacterial sex?
transformatio
transduction
conjugation
mitosis
When a pathogen alters its PAMPs and is no longer recognized by host antibodies, _____________ has occurred.
Conversion
Affinity
Immunity
Antigenic variation
The epidemiological triangle does not include:
Factors of the agent
Factors of the host
Factors of the environment
Factors of government control
To cause disease, pathogens must first:
Enter the host
Adhere to host tissues
Penetrate or evade host defenses
Damage the host tissues
Exit from the host
Most pathogens have a preferred portal of entry.
True
False
In biofilm environments, pathogenicity is more likely to occur when:
there are more microbes present
quorum sensing is occurring
the host is immunocompromised
all of these
Two variations of the Influenza A virus have combined to in the last year to form a more virulent strain. This is called:
antigenic shift
antigenic drift
Due to increased vaccinations and fewer susceptible individuals, the Influenza A virus has gradually started exhibiting mutations to its receptors. This is an example of:
antigenic shift
antigenic drift
The more motile a pathogen is, the more likely it will cause disease.
True
False
Which of the following bacteria does not have a flagella.
Pseudomonas aeruginosa
Staphylococcus aureus
Escherichia coli
Bacillus megaterium
Which of the following factors contribute to a microbes ability to invade a host:
Enzymes
Penetration methods
Capsules
All of these may contribute
Exotoxins are only found in G- bacteria.
True
False
Endotoxins are only found in G- cells.
True
False
Endotoxins indicate the presence of specific diseases.
True
False
Exotoxins are more toxic than endotoxins.
True
False
Many different microbes exhibit antigenic variation.
True
False
The presence of "mycotoxin" indicates that a patient has a _____ infection.
bacterial
fungal
protozoal
viral
Transduction can increase pathogenicity.
True
False
Endotoxins are released during:
binary fission and death
bacterial sex
lysogenic conversion
schizogony
Which is more soluble in body fluids:
endotoxins
exotoxins
Which is the primary cause of fevers?
endotoxin
exotoxin
In order for diptheria toxin to be released, what must occur?
A and B toxin must be present
The host must be immunocompromised
There must be more than 10,000 microbes
Biogenesis
If a patient has toxemia, where have toxins been found?
blood
lymph
skin
brain
Shigella flexneri expresses a glycoprotein that allows it to travel between host cells. It is called:
Coagulase
Cadherin
Perforin
Adhesin
The method used by bacteria like Yersinia pestis to avoid phagocytosis is:
capsule production
toxin release
host cell adhesion
viral lysogeny
Which of the following is a mechanical barrier to pathogens?
Defecation
Nutrients
pH
Temperature
Which of the following is a chemical barrier to pathogens?
defecation
urination
swallowing
secretions
The ID50 & LD50 is different for every pathogen.
True
False
