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Innate Immunity

Total questions: 60

Worksheet time: 30mins

Name
Class
Date
1.

Memory B cells are a part of the body’s:

a)

2nd line of defense

b)

3rd line of defense

c)

1st line of defense

d)

All of these

2.

The pyrogenic response is usually part of the body’s:

a)

2nd line of defense

b)

3rd line of defense

c)

1st line of defense

d)

All of these

3.

Humoral & Cellular immunity are part of:

a)

Adaptive immunity

b)

Innate immunity

c)

Both Innate & Adaptive

d)

The 3rd line of defense

4.

Which of the following is NOT part of adaptive immunity:

a)

Histamine

b)

Antibodies

c)

T cells

d)

All of these are part of adaptive immunity

5.

Which of the following is FALSE about mucous membranes?

a)

Contain glycoproteins

b)

Secretions have neutral pH

c)

Found in the ear, eye, genitourinary, gastrointestinal, and respiratory tract

d)

Are found near portals of entry and exit

6.

Which of the following are NOT physical mechanisms used by the body to remove pathogens:

a)

Urination

b)

Ciliary escalator

c)

Lysozyme

d)

Peristalsis

7.

Lactobacillus species in the female reproductive tract release lactosporin, an inhibitor of pathogenic E. coli colonization. Lactosporin is an:

a)

Opportunist

b)

Bacterioicin

c)

Antibiotic

d)

Probiotic

8.

Which of the following are nonnucleated cells that do not participate in immune responses, but are targets for siderophores?

a)

Leukocytes

b)

Platelets

c)

Lymphocytes

d)

Erythrocytes

9.

Sarah’s differential count is 12,650 WBCs/mm3. The normal range is 5,000 - 10,000 WBCs/mm3. What may this number indicate:

a)

Bacterial infections or side effects of medications

b)

Viral infections, pneumonia, or cancers

10.

Ben's differential count is 630 WBCs/mm3. The normal range is 5,000 - 10,000 WBCs/mm3. What may this number indicate:

a)

Bacterial infections or side effects of medications

b)

Viral infections, pneumonia, or cancers

11.

All of the following are signs of inflammation, EXCEPT:

a)

Pain

b)

Heat

c)

Redness

d)

Swelling

12.

During inflammation, phagocytes squeeze between endothelial cells of blood vessels using:

a)

Diapedesis

b)

Margination

c)

Vasodilation

d)

Prostiglandins

13.

Which of the following bacteria is more susceptible to the membrane attack complex (MAC):

a)

Gram negative

b)

Gram positive

c)

Mycolic acid

14.

The iron-binding protein found in RBC’s that is the normal target of bacterial siderophores is:

a)

Hemoglobin

b)

Ferritin

c)

Lactoferrin

d)

Transferrin

15.

Cells that trigger apoptosis of host cells during viral infections and cancer:

a)

Eosinophils

b)

Mast cells

c)

Natural killer cells

d)

Dendritic cells

16.

The antimicrobial peptide released by platelets that has a broad spectrum of activity against bacteria, fungi, viruses, and eukaryotic parasites.

a)

Dermacidin

b)

Defensins

c)

Transferrins

d)

Thrombocidin

17.

Which organ monitors blood for microbes and toxins.

a)

Spleen

b)

Liver

c)

Blood

d)

Lymph

18.

Phagocytes are part of BOTH the innate and adaptive immune systems.

a)

True

b)

False

19.

Microbial activity is most numerous in areas with low water activity (Aw).

a)

True

b)

False

20.

All three complement pathways can utilize C1-C9 proteins depending on the microbe present.

a)

True

b)

False

21.

All phagocytes are forms of WBC’s.

a)

True

b)

False

22.

Lack of resistance to an infection is termed immunity.

a)

True

b)

False

23.

Receptors on microbial cells that bind to activators on host cells are termed TLRs

a)

True

b)

False

24.

The innate system is activated by protein receptors in defensive cells which release _________; immune response regulators.

a)

histamines

b)

kinins

c)

kinases

d)

cytokines

25.

The protective protein of the epidermis that aids in waterproofing the skin, hair, and nails is termed _______.

a)

keratin

b)

dermis

c)

adipose

d)

actin

26.

Enzyme in water-based bodily secretions that hydrolyzes bonds in peptidoglycan:

a)

coagulase

b)

lysozyme

c)

hydrolase

d)

kinase

27.

Bone marrow is responsible for creating the formed elements of blood via the process of ________.

a)

lymphopoiesis

b)

anticoagulase

c)

hematopoiesis

d)

coagulase

28.

During allergic or inflammatory responses, the body’s granulocytic basophils release _________.

a)

hematoxylin

b)

streptolysin

c)

histamine

d)

coagulase

29.

Dead cells and body fluids that collect at the site of injury indicate a ________infection.

a)

bacterial

b)

purulent

c)

contaminated

d)

viral

30.

Interferons stimulate neighboring cells to produce viral replication inhibitors termed ________.

a)

antibacterial proteins

b)

antiviral proteins

c)

interferons

d)

anticoagulants

31.

Glycoprotein responsible for keeping membranes moist and trapping microbes:

a)

Tears

b)

Blood

c)

Mucus

d)

Lysozyme

32.

Second line defenses include:

a)

Microbiota

b)

T-cells

c)

NK cells

d)

WBCs

33.

Which body response leads to a rise in temperature?

a)

Sweating

b)

Shivering

34.

Which of the following is true regarding immunity?

a)

Innate immunity has memory. It becomes more effective over time.

b)

Adaptive immunity is specific for certain types of pathogens.

c)

Innate immunity is only found in vertebrates.

d)

Adaptive immunity is the first to respond to an infection

35.

Which response time is faster?

a)

Innate

b)

Adaptive

36.

Immunological memory is part of:

a)

adaptive immunity

b)

innate immunity

37.

Receptors on host cells that interact with and recognize microbes:

a)

toll-like receptors

b)

pathogen-associated molecular pattern

c)

adhesin

d)

cadherin

38.

Receptors on microbial cells that interact with host cells:

a)

toll-like receptors

b)

pathogen-associated molecular patterns

c)

cadherin

d)

adhesin

39.

Immunity that you are born with:

a)

adaptive

b)

innate

40.

Immunity that you aquire throughout your lifetime:

a)

adaptive

b)

innate

41.

TLRs bound to PAMPs induce the release of _____________ (chemical messengers).

a)

histamines

b)

kinins

c)

cytokines

d)

pyrogens

42.

Normal microbiota compete with pathogens via microbial _______.

a)

synergism

b)

antagonism

c)

commensalism

d)

parasitism

43.

Granulocyte responsible for protecting against worms:

a)

basophils

b)

eosinophils

c)

neutrophils

d)

monocytes

44.

Granulocyte responsible for protecting against allergic responses:

a)

basophils

b)

eosinophils

c)

neutrophils

d)

monocytes

45.

_____________ fibers trap microbes that make it into the lymph nodes.

a)

reticular

b)

neutrophil

c)

basophil

d)

T-lymphocyte

46.

Macrophages can be fixed or wandering.

a)

True

b)

False

47.

Phagocytes digest microbes within a:

a)

lysosome

b)

phagocyte

c)

phagolysosome

d)

vacuole

48.

Biofilms can resist phagocytosis.

a)

True

b)

False

49.

Scar tissue is formed via __________.

a)

fibrosis

b)

parenchyma

c)

stroma

d)

hematopoiesis

50.

A temperature of 37 degrees is considered a fever.

a)

True

b)

False

51.

Proteins responsible for the complement system are formed in the:

a)

heart

b)

blood

c)

liver

d)

spleen

52.

All three complement pathways trigger cytolysis, opsonization, and inflammation.

a)

True

b)

False

53.

The classical pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

54.

The lectin pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

55.

The alternative pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

56.

The opsonization pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

57.

The cytolysis pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

58.

The inflammation pathway uses which proteins:

a)

c1, c2, c3, & c4

b)

c2, c3, & c4

c)

c3

d)

c3, c5, c6, c7, c8, c9

e)

c3 & c5

59.

Chemotactic factors:

a)

allow motility

b)

attract phagocytes to an infection

c)

break down therapeutic drugs

d)

reduce fevers

60.

____________ warn host cells of a viral infection.

a)

Interferons

b)

Phagocytes

c)

Neutrophils

d)

Eosinophils