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WorksheetsHistophysiology Exam 4
Total questions: 81
Worksheet time: 2hrs 45mins
True or false: In order to be absorbed, electrolytes and minerals must be in solution and in free ionized form.
True
False
What cells do the bulk of absorption?
Villus cells
Crypt Cells
Paneth Cells
G cells
Chloride tends to be co-transported with _____ across villus cells.
Sodium
Potassium
Hydrogen
Sugars and Amino Acids
Where does most chloride get paracellularly absorbed at?
Upper duodenum
Lower duodenum
Upper jejunum
Lower Jejunum
The bulk of potassium absorption is accomplished using the ______.
NKCC2 Co-transporter
Cl- Co-transport
Active K Channel Pump
Paracellular Pathway
True or false: most of the sodium being absorbed in the duodenum is from the diet.
True
False
_____ secrete chloride, sodium, and water.
Villus cells
Crypt cells
M cells
Goblet cells
True or false: When crypt cells secrete Cl, Na is drawn by negative charge and water follows.
True
False
True or false: Larger solutes are less likely to participate in solvent drag than small solutes.
True
False
The bulk of what the large intestine does is produce ______.
Mucous
Chloride
Sodium
Water
True or false: If you have colitis in a dog, severely watery diarrhea will always occur.
True
False
What of the following are types of diarrhea?
Secretory
Malabsorption
Osmotic
Septic
What type of diarrhea is characterized by excessive chloride secretion by crypt cells, reduced activity of villus cells, damage to tissue resulting in Prostaglandin E2 and I2 production, and mucous production as a result of microbial toxins?
Secretory
Malabsorption
Osmotic
Septic
Bacterial toxins from ______ cause a release of serotonin from enteroendrocrine cells, resulting in an opening of calcium channels from adjacent cell basolateral membranes and an increased secretion of chloride.
Cholera
E. Coli
Salmonella
Rotavirus
True or false: TNF-alpha and other cytokines made by macrophages and lymphocytes can bind to receptors on crypt cells and activate adenyl cyclase, eventually causing hypersecretion.
True
False
___________ secretes enterotoxin which binds to receptors linked to guanylate cyclase activity, resulting in increased levels of Cyclic GMP activity that causes an increase in mostly intracellular calcium and eventually hypersecretion.
Salmonella
Vibrio cholera
Cytokines
Rotavirus
True or false: Enterotoxigenic E. Coli LT toxin activates adenylate cyclase by irreversibly binding to its own G-protein coupled receptors on enterocytes, causing secretory diarrhea.
True
False
True or false: Toxins and inflammation have no effect on Villus cell Na-Cl coupled absorption abilities.
True
False
What type of diarrhea specifically refers to the loss of villus cells, enzymes, or tight junctions?
Secretory
Malabsorptive
Osmotic
Septic
Which of the following are examples of protein losing enteropathy, in which protein leaks through damaged mucosa to enter the lumen of the gut instead of lacteals?
Porcine Epidemic Diarrheal Virus
Coccidiosis
Cryptosporidiosis
Johne's Disease
What type of blood in feces is likely to be red in color?
Melena
Frank
Carl
Which of the following results in just the tip of villus cells being destroyed in calves and piglets?
Transmissable Gastroenteritis (TGE)
Rotavirus
Porcine Epidemic Diarrheal Virus (PEDV)
Cryptosporidiosis
What malabsorptive diarrheal virus has a 100% piglet death loss associated with it? Hint: It destroys small intestine villus cells.
Porcine Epidemic Diarrheal Virus
Coccidiosis
Cryptosporidiosis
Rotavirus
What usually gives veterinary students malabsorptive diarrhea and attacks both ileal cells and proximal colon cells?
Coccidiosis
Rotavirus
Cryptosporidiosis
Parvovirus
Can you save a 3 day old piglet with TGE by using colon compensation? Hint: the animal's bacteria must be able to convert CHO to VFA to provide energy in addition to the Na/Water absorption.
Yes
No
What type of diarrhea is typically characterized by feeding of non-absorbable or poorly absorbable food? Example: Feeding calves milk replacer, which does not form curds in the abomasum and speeds rate at which it enters the intestines.
Secretory
Malabsorptive
Osmotic
Septic
Sodium is transported ______ its chemical and electrical gradient at the apical membrane and _______ its chemical and electrical gradient at the basolateral membrane.
Up, down
Up, up
Down, Down
Down, Up
Intracellular Chloride concentrations are ______ than extracellular concentrations.
Higher
Lower
T/F: After water has been absorbed, the luminal K concentration is high enough to promote the bulk of the K to move transcellularly into the blood.
True
False
What cell type is the primary target for Canine Parvo virus?
Paneth cells
Villus absorptive cells
Regenerative stem cells
Secretory crypt cells
The Colon is able to absorb which of the following?
Water
Potassium
Sugars
Amino Acids
Volatile fatty acids
Why would you want to administer opiates to reduce gut motility?
to allow other drugs to reach the pathogen
so the gut won't damage itself from hypermotility
to allow a chance for increased absorption by not flushing lumen contents
What is the purpose of administering hypertonic saline to a dehydrated animal rather than isotonic saline?
The animal truly isn't dehydrated, it just has an ion deficiency
Hypertonic blood steals intracellular water stores to return the blood to a normal volume
It is easier to give a little hypertonic saline rather than a large amount of isotonic saline
The increased ion concentration promoted hydrolysis of compounds to create more water
Why does the presence of oligosaccharides in feed reduce feed intake in neonates?
It sends satiety signals to the satiety center and the animal does not want to eat
oligosaccharides can damage the villus cells and leads to general malabsorption of nutrients
Neonates do not have the microbes in their colon required to break down oligosaccharides
What is the main problem with the avian digestive tract?
They can't grind feed to obtain all the nutrients out of it
Their gut microbes absorb too many nutrients, leaving few for the bird
The rate of passage of feed is too fast, so digestion is poor
The production of uric acid instead of urea is very energy inefficient
Which birds would do not have a Crop?
Pigeons
Owls
Raptors
Chickens
Insectivorous birds
Which of the following is true about the avian proventriculus?
Secretes HCl and digestive enzymes
Epithelium is continually replaces due to the absence of mucus
adenomeres take the place of gastric glands found in mammals
It can act as a storage pouch for species without a Crop
T/F: The ventriculus lumen is lined with a thick layer of keratinized epithelial tissue known as the "pellicle" or "cuticle".
True
False
What is different about Glucose absorption in poultry compared to mammals?
Glucose is transported by facilitated diffusion
Chloride is used as a co-transporter instead of Sodium
Glucose cannot be absorbed at all across the intestines
Paracellular transport is the main method of Glucose absorption
Identify the correct order of structures from orad to aborad.
Proctodaeum, Coprodaeum, Rectum, Urodaeum, Cloaca
Rectum, Proctodaeum, Urodaeum, Coprodaeum, Cloaca
Rectum, Cloaca, Coprodaeum, Urodaeum, Proctodaeum
Rectum, Coprodaeum, Urodaeum, Proctodaeum, Cloaca
T/F: The Bursa of Fabricius is the site of B cell maturation
True
False
Which of the following is a theory about how satiety and feed intake are controlled?
Glucostatic theory
CCK/Ghrelin/Peptide YY theory
Lipostatic theory
Thermostatic theory
Hepatic Oxidation theory
What is the main advantage of gut microbes for ruminants and hindgut fermenters?
Utilization of plant tissue structural carbohydrates
Competitive inhibition of pathogenic microbes
Faster growth rate
T/F: Probiotics is a mixture of normal gut bacteria to promote colonization within the animal
True
False
Can you give Penicillin to rabbits? Why?
Yes, because rabbits have gram positive bacteria and Penicillin targets gram negative bacteria
Yes, because rabbits have gram negative bacteria and Penicillin targets gram positive bacteria
No, because rabbits have gram positive bacteria and Penicillin targets gram positive bacteria
No, because rabbits have gram negative bacteria and Penicillin targets gram negative bacteria
When do you begin to see anaerobic gut microbes?
Mouth/pharynx/esophagus
Stomach
Upper small intestine
lower intestine/colon
T/F: Prebiotics are substances that aim to selectively stimulate the growth and/or activity of lactobacilli or bifidobacteria in the colon.
True
False
Changes in gut microbiomes can have varying effects on what?
Obesity
Depression
Stress
Grades on Dr. Goff's exams
Leaky gut
Which is not a Browser
Camelids
Deer
Giraffe
Hippopotamus
What function(s) do the saccules in the Camelid rumen provide?
increased surface area for faster fermentation
enhances mixing during contractions
increase the volume of food that can be ingested
sampling for pathogens by M cells
Which of the following is NOT a ruminant
Kangaroo
Hippopotamus
Koala
Alpaca
Which of the following is NOT a hindgut fermenter
Chinchilla
Elephant
Black Rhinoceros
Dolphin
What is the purpose of accumulation of triglycerides and fat soluble vitamins in shark livers?
Fast energy stores when needed
Buoyancy
High levels of fat metabolism
Salt water fish want to _______ salt across gills, fresh water fish want to _______ salt across its gills.
Absorb, Excrete
Absorb, Absorb
Excrete, Absorb
Excrete, Excrete
Mammary gland are adapted ________ glands and release ________ type secretions.
Sweat, Merocrine
Salivary, Apocrine
Sweat, Apocrine
Salivary, Merocrine
T/F: Oxytocin released due to the suckling reflex causes alveolar cells to secrete proteins and other stuff into the alveolar lumen.
True
False
Which association is incorrect?
Mare: 2 teat ducts/teat
Cow: 4 inguinal teats
Sow: 10-14 teats
Queen: 5 pairs of teats
Which association is incorrect?
Thoracic mammary gland: internal thoracic artery
Abdominal mammary glands: phrenicoabdominal artery
Inguinal mammary glands: external pudendal artery
All are correct
T/F: Most nutrients and compounds are transported into the alveolar lumen paracellularly
True
False
Which of the following is true regarding lactogenesis?
Growth of the mammary tissue does not begin until post parturition
Placental lactogen causes mammary gland development in the sow
Milk production is directly linked to number of functional alveoli
Progesterone increases the number of prolactin receptors on alveolar cells
How does bacteria get to a cow's udder to cause mastitis?
bacteria travels through the external pudendal artery to the mammary gland
bacteria travels through the wall of the udder to the mammary gland
bacteria ascends the teat canal into the mammary gland
magic
Why should you give fresh feed to a cow immediately after milking?
positive reinforcement
To keep the cow standing to allow closure of the teat sphincter before laying down
to replenish the cow from all the nutrients lost to the milk
T/F: photoperiod is the #1 driver for most birds to begin reproductive period.
True
False
Storage tubules at the uterovaginal junction can store sperm to fertilize eggs for a period of time after insemination. How many days after insemination can the chicken and turkey fertilize eggs, respectively?
7-14, 40
21, 28
21, 21
40, 7-14
In hens, which ovary typically goes on to develop fully?
Right
Left
When is the shell is added to an egg?
Infundibulum
Magnum
Isthmus
nidamental gland
vagina
What stimuli can cause a hen to exhibit brooding behaviors?
prolactin release
decreased feed intake
decreased length of photoperiod
Which association is incorrect?
Oocyte: follicular phase
Corpus luteum: luteal phase
Theca cells: within the follicle
Granulosa cells: acted upon by FSH
T/F: Estrus is a series of temporal transitions that define the female reproductive cycle.
True
False
Anestrous is seen in what patterns of the estrous cycle
monoestrous
diestrous
polyestrous
seasonal polyestrous
Which hormone peaks at opposite times than the others during the estrous cycle?
Estrogen
FSH
LH
Progesterone
Which hormones initiate change in gene expression via transmembrane receptors?
Estrogen
FSH
Inhibin
GnRH
PGE-2a
When are the main 4 hormones involved in the estrous cycle (E2, P4, LH, FSH) are at their lowest?
At ovulation and several days after
Mid-proestrus
late metestrus
early estrus
Which of the following needs to happen for ovulation to occur?
antrum completely encapsulates the ovum
one follicle within the cohort exerts a dominant effect on the others
Increased LH release from anterior pituitary
Increased E2 production from the follicle
Which hormone is inhibited the strongest by Inhibin?
Estrogen
FSH
LH
GnRH
Identify the incorrect feedback mechanism of the follicular phase.
GnRH promotes LH and FSH from the anterior pituitary
E2 promotes GnRH release from the hypothalamus
E2 promotes its own sythesis at the follicle (theca cell)
Inhibin prevents FSH release from anterior pituitary
What are the two subphases of the luteal phase?
Diestrus
Proestrus
Estrus
Metestrus
What is the order of progression for the luteal phase?
Corpus Hemorhagicum, Corpus Luteum, Corpus Albicans
Corpus Albicans, Corpus Hemorhagicum, Corpus Luteum
Corpus Luteum, Corpus Hemorhagicum, Corpus Albicans
How does oxytocin and PGF-2a transport back and forth from the ovary to the uterus?
Paracrine action
Nervous action
Counter current exchange
Which of the following is not a feedback mechanism of the luteal phase?
P4 prevents GnRH release at the hypothalamus
P4 prevents GnRH activity at the anterior pituitary
P4 prevents oxytocin synthesis in the endometrium
Oxytocin stimulates PGF-2a synthesis in the endometrium
PGF-2a stimulates oxytocin release from the CL
T/F: animals are sensitive to PGF-2a day 0 to day 5 post-estrus.
True
False
