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Medicinal Chemistry Review

Total questions: 46

Worksheet time: 52mins

Name
Class
Date
1.

Penicillin is a/an:

a)

pain killer

b)

antibiotic

c)

heart drug

d)

diabetes drug

2.

Dr Fleming left some disease-causing bacteria on a dish and went on holiday, when he came back he found:

a)

the bacteria had grown

b)

a bad smell that made him sick

c)

mould had stopped the bacteria growing

d)

he had been fired for leaving a mess

3.

Cephalosporins and Penicillin MOA (mechanism of action) is:

a)

inhibit protein synthesis

b)

destroys cell wall

c)

inhibit growth or multiplication

4.

What is the Class Use of acetaminophen?

a)

Analgesic

b)

NSAID

c)

Antipyretic

d)

Anticoagulent

5.

True or false: an antipyretic reduces fever

a)

True

b)

False

6.
Identify the term used to describe an injection that is given just under the skin of an animal :
a)
Subcutaneous
b)
Intramuscular
c)
Intravenous
d)
Epidural
7.
Identify the term used to describe an injection that is given into the vein of an animal :
a)
Subcutaneous
b)
Intramuscular
c)
Intravenous
d)
Epidural
8.
Identify the category of drug which acts to prevent blood from clotting :
a)
Analgesic
b)
Antibiotic
c)
Anticoagulant
d)
Antidiuretic
9.
Identify the category of drug which acts to relieve pain :
a)
Analgesic
b)
Antibiotic
c)
Anticoagulant
d)
Antidiuretic
10.

What is the mechanism of action for Morphine?

a)

Blocks acetylcholine at the SA node

b)

Binds to GABA receptors

c)

Binds to opioid receptors and relieves pain through CNS action

d)

Blocks calcium channels and binds with potassium to prevent cramps

11.

When used to treat pain, prescription opioid drugs can be addictive.

a)

True

b)

False

12.
What is radioactive decay?
a)
The spontaneous breakdown of an atomic nucleus resulting in only energy release
b)
The spontaneous breakdown of an atomic nucleus resulting in only matter release
c)
The spontaneous breakdown of an atomic nucleus resulting in a release of energy and matter
d)
The decay of the use of radios and the increased use of televisions.
13.

What is the major issue with synthesizing Tamiflu?

a)

The solvents used are toxic

b)

The precursor is toxic

c)

The source for the precursor has low yield

d)

The synthesis process releases greenhouse gasess

14.
All bacteria have DNA. 
a)
true
b)
false
15.
The flu is caused by
a)
bacteria
b)
virus
16.
Antibiotic resistant bacteria are a problem because:
a)
we can't help people with those infections
b)
bacteria smell pretty bad
c)
something about viruses
d)
they are not a problem, I love being sick
17.
People are making antibiotic resistance worse by:
a)
taking antibiotics only when they need them
b)
putting antibiotics into our food and environment
c)
not sharing antibiotics with others
18.

The rate that bacteria develop antibiotic resistance at can be sped up by:

a)

Exposure to lower levels of antimicrobials than prescribed

b)

2.Exposure to broad-spectrum antibiotics (which aren’t specific to a microbe)

c)

3.Overuse of antibiotics in foods/agriculture

d)

4. All of the above

19.

Broad spectrum antibiotics are good because:

a)

They Kill many different pathogenic bacteria

b)

They are really cheap to buy

c)

They cause antibiotic resistance

d)

None of the above

20.

Broad spectrum antibiotics are bad because:

a)

They kill many different pathogenic bacteria

b)

They are really cheap to buy

c)

They can increase the rate of development of antibiotic resistance

d)

All of the above

21.

What can we do to reduce the rate of development of antibiotic resistant strains of bacteria

a)

Always finish a course of antibiotics

b)

Only take antibiotics when they are really needed

c)

Take antibiotics whenever it is possible

d)

Reduce the amount of antibiotics given to animals in the farming industry

22.
Particles made up of proteins, nucleic acids, and sometimes lipids that can reproduce only by infecting living cells are called
a)
bacteria.
b)
capsids.
c)
prophages.
d)
viruses.
23.
HIV is caused by a 
a)
bacterium.
b)
virus.
24.
A preparation of weakened or killed pathogens or inactivated toxins that are injected into the body to prevent certain diseases is called a/an
a)
antibiotic.
b)
antiviral drug.
c)
vaccine.
d)
pathogen.
25.
A chemical that keeps a virus from invading a cell or causing the cell to make virus proteins is a
a)
antibiotic
b)
mutant
c)
antifungal
d)
antiviral
26.
Organism populations that reproduce quickly evolve quickly
a)
true
b)
false
27.

What is the difference between an antiviral and antiretroviral?

a)

There is no difference, both combat viruses

b)

An antiviral prevents viruses from entering the host cell while an antiretroviral prevents virus reproduction

c)

An antiviral prevents virus reproduction while and antiretroviral presents viruses from entering the host cell

d)

An antiviral destroys viruses outside of the host cell while an antiretroviral destroys them inside the host cell

28.

Why are viruses so difficult to treat? (you may choose more than one answer)

a)

They do not have a cell structure to target

b)

They reproduce more rapidly than bacteria

c)

They mutate more rapidly than bacteria

d)

They can lie dormant for long periods of time

29.

What are antacids used for?

a)

They prevent the release of excess acid in the stomach

b)

They lower the pH of the acid in the stomach

c)

They raise the pH of the acid in the stomach

d)

They trigger the healing process for ulcers

30.

How does Prilosec work?

a)

It is a proton pump inhibitor, directly preventing the release of acid into the stomach

b)

It is an H2 receptor antagonist, indirectly preventing the release of acid into the stomach

c)

It is an H2 receptor antagonist, directly preventing the release of acid into the stomach

d)

It is an antacid, used to neutralize the acid that has already been released in the stomach

31.

Why is codeine considered a safer drug to use than morphine?

a)

It has a reduced ability to cross the blood-brain barrier, making it weaker

b)

It has a reduced ability to bond with opioid receptors in the brain, making it weaker

c)

It is not a strong analgesic and therefore doesn't produce the same narcotic effects as morphine

d)

It is not a pro-drug and does not get converted to a more dangerous drug by the body like morphine does

32.

Why is diamorphine a more dangerous drug than morphine?

a)

The esters in its structure make it easier to bind to opioid receptors in the brain

b)

The esters in its structure make it easier to pass the blood-brain barrier

c)

The esters in its structure are toxic to the brain causing more negative side-effects

d)

It is a pro-drug that reacts with esterase to be better at binding to opioid receptors in the brain

33.

What type of reaction produces diamorphine?

a)

The methylation of morphine

b)

The esterification of morphine

c)

The nucleophilic substitution of morphine

d)

The hydrogenation of morphine

34.

What are bacteria that are antibiotic resistant capable of doing?

a)

Not binding with the antibiotic structure

b)

Breaking the beta-lactam ring

c)

Binding to the beta-lactam ring

d)

Blocking the beta-lactam ring

35.

Why is aspirin chemically modified before being taken as a drug?

a)

To make the chemical structure more reactive

b)

To make the chemical structure less toxic

c)

To make the chemical structure less likely to be digested

d)

To make the chemical structure more water soluble

36.

What does bioavailability mean?

a)

Whether the drug can be found in nature

b)

How much of a drug is included in every dose

c)

How easy a drug is to synthesize

d)

How much of the drug reaches its target

37.
H1N1 flu is a highly contagious viral infection caused by the influenza A (H1N1) virus. The symptoms of H1N1 flu are listed in the box below. An antiviral agent administered within 48 hours of the appearance of symptoms can reduce the severity of the illness. 
Why is it important to administer an antiviral agent to an infected person within 48 hours of the appearance of symptoms?
a)
The H1N1 virus is dormant in cells.
b)
The H1N1 virus replicates quickly
c)
The H1N1 virus does not mutate.
d)
The H1N1 virus is transmitted through a vector host, such as a mosquito.
38.

In animal studies, the therapeutic index is...

a)

.....the lethal dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.

b)

....the minimum effective dose for 50% of the population divided by the lethal dose of a drug for 50% of the population. 

c)

.....the toxic dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.

d)

.....the lethal dose of a drug for 50% of the population divided by the minimum toxic dose for 50% of the population.

39.

The therapeutic window is the...

a)

....range of dosages between the minimum amounts of the drug that produce a toxic effect effect and a medically unacceptable adverse effect 

b)

....range of dosages between the minimum amounts of the drug that produce an undesired effect and a medically unacceptable adverse effect 

c)

....range of dosages between the minimum amounts of the drug that produce the desired effect and a medically unacceptable adverse effect 

d)

....range of dosages between the minimum amounts of the drug that produce the desired effect and the toxic dose. 

40.

Aspirin is prepared from

a)

sandalwood acid

b)

carboxylic acids

c)

ethanoyl chloride

d)

salicylic acid 

41.

Which of the following penicillins is likely to be the most soluble?

a)

penicillin G

b)

penicillin v

c)

Ampicillin

d)

Amoxicillin

42.

Which functional group does penicillin NOT have.

a)

alkene

b)

carbonyl

c)

carboxylic acid

d)

amine

43.

First pass metabolism is observed in

a)

Sublingual Administration

             

b)

  Oral Administration

             

c)

  I V (Intra Venous) Administration

           

d)

     Both A and C

44.

What is the significance of the blood-brain barrier in drug design?

a)

The blood-brain barrier is significant in drug design because it affects drug delivery to the central nervous system.

b)

The blood-brain barrier prevents all drugs from entering the bloodstream.

c)

The blood-brain barrier is irrelevant to drug efficacy in the body.

d)

The blood-brain barrier enhances drug absorption in the stomach.

45.

TRUE OR FALSE. All drugs are medications, but NOT all medications are drugs.

a)

True

b)

False

46.

How does Antiviral medication help with viral infections?

a)

Antivirals do not allow the virus to attach to cells or reproduce inside cells

b)

Antivirals destroy the cell wall of viruses

c)

Antivirals hack into viruses corrupting their DNA