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WorksheetsMedicinal Chemistry Review
Total questions: 46
Worksheet time: 52mins
Penicillin is a/an:
pain killer
antibiotic
heart drug
diabetes drug
Dr Fleming left some disease-causing bacteria on a dish and went on holiday, when he came back he found:
the bacteria had grown
a bad smell that made him sick
mould had stopped the bacteria growing
he had been fired for leaving a mess
Cephalosporins and Penicillin MOA (mechanism of action) is:
inhibit protein synthesis
destroys cell wall
inhibit growth or multiplication
What is the Class Use of acetaminophen?
Analgesic
NSAID
Antipyretic
Anticoagulent
True or false: an antipyretic reduces fever
True
False
What is the mechanism of action for Morphine?
Blocks acetylcholine at the SA node
Binds to GABA receptors
Binds to opioid receptors and relieves pain through CNS action
Blocks calcium channels and binds with potassium to prevent cramps
When used to treat pain, prescription opioid drugs can be addictive.
True
False
What is the major issue with synthesizing Tamiflu?
The solvents used are toxic
The precursor is toxic
The source for the precursor has low yield
The synthesis process releases greenhouse gasess
The rate that bacteria develop antibiotic resistance at can be sped up by:
Exposure to lower levels of antimicrobials than prescribed
2.Exposure to broad-spectrum antibiotics (which aren’t specific to a microbe)
3.Overuse of antibiotics in foods/agriculture
4. All of the above
Broad spectrum antibiotics are good because:
They Kill many different pathogenic bacteria
They are really cheap to buy
They cause antibiotic resistance
None of the above
Broad spectrum antibiotics are bad because:
They kill many different pathogenic bacteria
They are really cheap to buy
They can increase the rate of development of antibiotic resistance
All of the above
What can we do to reduce the rate of development of antibiotic resistant strains of bacteria
Always finish a course of antibiotics
Only take antibiotics when they are really needed
Take antibiotics whenever it is possible
Reduce the amount of antibiotics given to animals in the farming industry
What is the difference between an antiviral and antiretroviral?
There is no difference, both combat viruses
An antiviral prevents viruses from entering the host cell while an antiretroviral prevents virus reproduction
An antiviral prevents virus reproduction while and antiretroviral presents viruses from entering the host cell
An antiviral destroys viruses outside of the host cell while an antiretroviral destroys them inside the host cell
Why are viruses so difficult to treat? (you may choose more than one answer)
They do not have a cell structure to target
They reproduce more rapidly than bacteria
They mutate more rapidly than bacteria
They can lie dormant for long periods of time
What are antacids used for?
They prevent the release of excess acid in the stomach
They lower the pH of the acid in the stomach
They raise the pH of the acid in the stomach
They trigger the healing process for ulcers
How does Prilosec work?
It is a proton pump inhibitor, directly preventing the release of acid into the stomach
It is an H2 receptor antagonist, indirectly preventing the release of acid into the stomach
It is an H2 receptor antagonist, directly preventing the release of acid into the stomach
It is an antacid, used to neutralize the acid that has already been released in the stomach
Why is codeine considered a safer drug to use than morphine?
It has a reduced ability to cross the blood-brain barrier, making it weaker
It has a reduced ability to bond with opioid receptors in the brain, making it weaker
It is not a strong analgesic and therefore doesn't produce the same narcotic effects as morphine
It is not a pro-drug and does not get converted to a more dangerous drug by the body like morphine does
Why is diamorphine a more dangerous drug than morphine?
The esters in its structure make it easier to bind to opioid receptors in the brain
The esters in its structure make it easier to pass the blood-brain barrier
The esters in its structure are toxic to the brain causing more negative side-effects
It is a pro-drug that reacts with esterase to be better at binding to opioid receptors in the brain
What type of reaction produces diamorphine?
The methylation of morphine
The esterification of morphine
The nucleophilic substitution of morphine
The hydrogenation of morphine
What are bacteria that are antibiotic resistant capable of doing?
Not binding with the antibiotic structure
Breaking the beta-lactam ring
Binding to the beta-lactam ring
Blocking the beta-lactam ring
Why is aspirin chemically modified before being taken as a drug?
To make the chemical structure more reactive
To make the chemical structure less toxic
To make the chemical structure less likely to be digested
To make the chemical structure more water soluble
What does bioavailability mean?
Whether the drug can be found in nature
How much of a drug is included in every dose
How easy a drug is to synthesize
How much of the drug reaches its target
Why is it important to administer an antiviral agent to an infected person within 48 hours of the appearance of symptoms?
In animal studies, the therapeutic index is...
.....the lethal dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.
....the minimum effective dose for 50% of the population divided by the lethal dose of a drug for 50% of the population.
.....the toxic dose of a drug for 50% of the population divided by the minimum effective dose for 50% of the population.
.....the lethal dose of a drug for 50% of the population divided by the minimum toxic dose for 50% of the population.
The therapeutic window is the...
....range of dosages between the minimum amounts of the drug that produce a toxic effect effect and a medically unacceptable adverse effect
....range of dosages between the minimum amounts of the drug that produce an undesired effect and a medically unacceptable adverse effect
....range of dosages between the minimum amounts of the drug that produce the desired effect and a medically unacceptable adverse effect
....range of dosages between the minimum amounts of the drug that produce the desired effect and the toxic dose.
Aspirin is prepared from
sandalwood acid
carboxylic acids
ethanoyl chloride
salicylic acid
Which of the following penicillins is likely to be the most soluble?
penicillin G
penicillin v
Ampicillin
Amoxicillin
Which functional group does penicillin NOT have.
alkene
carbonyl
carboxylic acid
amine
First pass metabolism is observed in
Sublingual Administration
Oral Administration
I V (Intra Venous) Administration
Both A and C
What is the significance of the blood-brain barrier in drug design?
The blood-brain barrier is significant in drug design because it affects drug delivery to the central nervous system.
The blood-brain barrier prevents all drugs from entering the bloodstream.
The blood-brain barrier is irrelevant to drug efficacy in the body.
The blood-brain barrier enhances drug absorption in the stomach.
TRUE OR FALSE. All drugs are medications, but NOT all medications are drugs.
True
False
How does Antiviral medication help with viral infections?
Antivirals do not allow the virus to attach to cells or reproduce inside cells
Antivirals destroy the cell wall of viruses
Antivirals hack into viruses corrupting their DNA
