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WorksheetsBiochem 2
Total questions: 57
Worksheet time: 2hrs 54mins
The urea cycle gets its Nitrogen from which Amino Acids?
Glutamate; Aspartate
Glutamate; Arginine
Glycine; Arginine
Glycine; Aspartate
Nitrogen comes and goes through glutamate via transamination. This transamination can turn into what molecule from glutamate?
a-ketoglutarate
Aspartate
Arginine
Acetyl-CoA
How much energy is stored in fat?
1 kcal/g
4 kcal/g
9 kcal/g
10 kcal/g
What are the products of glycolysis?
2 pyruvate, 2 ATP, 2 NADH, 2 H2O, 2 H
3 pyruvate, 2 ATP, 2 NADH, 2 H2O, 2 H
2 pyruvate, 6 ATP, 2 NADH, 2 H2O, 2 H
2 pyruvate, 2 ATP, 4 NADH, 2 H2O, 2 H
Which enzyme is the most important in glycolysis?
Hexokinase
Glucokinase
Phosphofructokinase
Pyruvate kinase
The Krebs cycle starts and ends with what compound?
Pyruvate
Oxaloacetate
Citrate
Succinate
Pyruvate enters the CAC via conversion to Acetyl-CoA. Acetyl combines with oxaloacetate to create citrate. Citrate can inhibit which enzyme in glycolysis?
Hexokinase
Glucokinase
Phosphofructokinase
Pyruvate kinase
Inside the inner mitochondrial membrane, there are many complexes. Complex III accepts electrons from the Q-protein and what?
FADH2
NADPH
NADH
Pyruvate
Glucose can theoretically yield how much glucose?
30 ATP
32 ATP
36 ATP
38 ATP
The hormones Cortisol and Glucagon affect gluconeogenesis by regulation of what enzyme?
Pyruvate carboxylase
Fructose-1,6-biphosphatase
Phosphoenolpyruvate carboxykinase
Glucose-6-phosphatase
The pentose phosphate pathway is important for creating a molecule that can eliminate toxic oxygen radicals. What molecule is it?
NADH
FADH2
NADPH
Ribulose-5-phosphate
RBC death due to loss of NADPH is caused by which deficiency?
G6PDH
Tay-Sachs
Xeroderma pigmentosa
Diabetes Mellitus
What is the committing enzyme for glycogen synthesis?
Hexokinase
Phoshophofructokinase
Phosphoenolpyruvate carboxykinase
Pyruvate kinase
Glycogen phosphorylase is under the control of epinephrine and glucagon, both which promote activation of which carbohydrate metabolism?
Glycogenolysis
FA synthesis
PPP
Ketone synthesis
The committing step for FA synthesis uses Acetyl-CoA carboxylase to produce which molecule?
Malonyl-CoA
Acetyl-CoA
Bicarbonate
Citrate
Acetyl-CoA carboxylase can be activated by an allosteric modification by which molecule?
Citrate
Succinate
Palmitoyl-CoA
Insulin
Acetyl-CoA Carboxylase can be inactivated by the hormone Glucagon via which enzyme?
Protein kinase
Citrate
Palmitoyl-CoA
Insulin
A F.A. strand that is longer than 12C have to use a special transporter to get into the mitochondria to be degraded. What is the name of the enzyme that removes carnitine?
CPT I
CPT II
translocase
CPT III
FA degradation starts in the cytoplasm and ends in the mitochondria. Once inside the mitochondria it goes through a process called B-oxidation. Acetyl-CoA is created by which enzyme?
Acyl-CoA dehydrogenase
Enoyl-CoA hydratase
L-3-hydroxyacyl-CoA dehydrogenase
B-ketothiolase
Which one is a ketone body?
Acetone
Citrate
Succinyl-CoA
Acetyl-CoA
If you are missing the enzyme B-N-acteylhexosaminidase, you may have which disease?
Tay-Sachs
Xeroderma pigmentosa
G6PDH
Prions
In the committing step of Cholesterol, HMG-CoA reductase is used to create what molecule?
HMG-CoA
Acetoacetate
Mevalonic acid
Squalene
Statins are an important drug for reducing cholesterol in patients. What do statins inhibit?
Acetyl-CoA
Squalene
HMG-CoA reductase
Phosphofructokinase
What binds to ergosterol and causes cell leakage and eventually cell death?
Ionophore
Polyenes
Ca channel blockers
Histamine blockers
If you were having heartburn, you might take a drug named Pantoprazole. This drug would inhibit what?
Ca channels
H2 receptors
Proton pumps
Ionophores
Intracellular steroid receptors can be genomic, affect DNA synthesis. Intracellular steroid receptors would be what group of cell signals?
Group I
Group II
Group II signals have different a-subunits, creating different G-proteins. Which G-protein stimulates phospholipase C?
Gs
Gi
Gq
Gt
Adenylyl cyclase forms the secondary messenger cAMP, which activates what?
DAG
PIP
Phospholipase C kinase
Protein kinase A
DAG and IP3 are created from the cleavage of PIP. The activation of what causes the cleavage?
Protein kinase A
cAMP
Phospholipase C
adenyl cyclase
The secondary messenger IP3 being cleaved from PIP causes the intracellular release of which ion?
Ca
Na
K
Cl
Speciality structures congregate together on the cell membrane to help with cell signaling are called what?
Lipid rafts
Poylenes
Na/K pump
Ionphores
The JAK-STAT mechanism is used to do what?
Activation of Transcription
Activation of Translation
DNA Replication
DNA Mutations
Which strand contains Okazaki fragments?
Leading strand
Lagging strand
Which enzyme cuts the phosphate backbone to untangle DNA strands?
DNA polymerase
Helicase
Topoisomerase
Ligase
At the end of transcription, the addition of several adenine units is known as what?
3’ Poly-A tail
5’ Poly-A tail
3’ cap
5’ cap
HIV is unique in that it can synthesize DNA from RNA, using reverse transcriptase. Which drug is a retroviral?
AZT
Prantoprazole
Timidine
Cyclins
Which ribosome, in humans, establishes the start site for mRNA?
40S
60S
30S
50S
In normal body conditions, larger proteins require help folding into larger protein structures. What helps fold the proteins?
Chaperones
Heat shock proteins
Ribosome
ER
Histones tightly wrap DNA. What enzyme allows RNA polymerase access to the DNA?
Histone deactylase
Histone acetyl transferase
Histone carboxylase
Histone kinase
If a point mutation switches an C for an A, it would be what type of mutation?
Transition
Transversion
Frameshift
Point
What enzyme is involved with sensing incorrect bases in DNA repair?
Endonucleases
Exonucleases
Polymerase
Ligase
What disorder has to do with cyclobutane rings being formed?
Xeroderma pigmentosa
Tay-Sachs
G6PDH
Diabetes Mellitus
What detects DNA damage during the cell cycle?
p53
p21
p16
p27
During which phase of the cell cycle do the cells start to lose cell cycle proteins?
G1
G2
S
G0
During M phase, securin is degraded by what?
anaphase-promoting complex
CDK4
Separase
Mitosis promoting factor
Cancer treatment can be done in different ways. One way is to use Vincristine and Taxol to target what in cancer cells?
Microtubules
Nucleus
RER
Cell Membrane
In a well fed state, High ATP and citrate inhibit phosphofructokinase-1. This causes G6P to do which one of the following?
Glycogenesis
Glcogenolysis
Glycolysis
Gluconeogenesis
If you just ate a large meal and have a high blood glucose level, your body will go into glycogenesis due to which hormone?
Insulin
Cortisol
Glucagon
What means the buildup of molecules?
Anabolism
Catabolism
If you have high levels of energy and Acetyl-CoA, it stimulates pyruvate carboxylase causing pyruvate to go to which carbohydrate metabolism?
Gluconeogenesis
Kreb Cycle
Oxidative Phosphorylation
Ketone Synthesis
During anaerobic respiration pyruvate can be converted to lactate to keep glycolysis going. In the liver, this process is known as what?
Cori cycle
Alanine cycle
Kreb cycle
Ketone cycle
What stimulates lactase dehydrogenase to create lactate in anaerobic skeletal muscles?
Increased NADH levels
Decreased NADH levels
Increased ATP levels
Decreased CO2 levels
During starvation, the brain uses ketone bodies for energy. What molecule do ketone bodies come from?
Acetyl-CoA
Pyruvate
G6P
Glucose
Glucagon acts mainly on the liver to stimulate production of glucose. Where is glucagon produced?
Pancreatic B-cells
Pancreatic A-cells
Prancreatic C-cells
Liver A-cells
Epinephrine and norepinephrine immediately act on regulating metabolism. Theses hormones are classified as _____________.
Catecholamines
Glucocorticoid
Sphingolipids
Triglycerides
Stress stimulates corticotrophin-releasing factors and adrenocorticotropic hormone, which release cortisol. Cortisol increase blood glucose levels by doing what?
Breakdown of muscle protein
Creating cholesterol
Create ketone bodies
Breakdown of fatty acids
Which Diabetes Mellitus is an autoimmune issue and can be treated with injections?
Type 2
Type 1
Type 3
Type 4
