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Worksheets

Biochem 2

Total questions: 57

Worksheet time: 2hrs 54mins

Name
Class
Date
1.

The urea cycle gets its Nitrogen from which Amino Acids?

a)

Glutamate; Aspartate

b)

Glutamate; Arginine

c)

Glycine; Arginine

d)

Glycine; Aspartate

2.

Nitrogen comes and goes through glutamate via transamination. This transamination can turn into what molecule from glutamate?

a)

a-ketoglutarate

b)

Aspartate

c)

Arginine

d)

Acetyl-CoA

3.

How much energy is stored in fat?

a)

1 kcal/g

b)

4 kcal/g

c)

9 kcal/g

d)

10 kcal/g

4.

What are the products of glycolysis?

a)

2 pyruvate, 2 ATP, 2 NADH, 2 H2O, 2 H

b)

3 pyruvate, 2 ATP, 2 NADH, 2 H2O, 2 H

c)

2 pyruvate, 6 ATP, 2 NADH, 2 H2O, 2 H

d)

2 pyruvate, 2 ATP, 4 NADH, 2 H2O, 2 H

5.

Which enzyme is the most important in glycolysis?

a)

Hexokinase

b)

Glucokinase

c)

Phosphofructokinase

d)

Pyruvate kinase

6.

The Krebs cycle starts and ends with what compound?

a)

Pyruvate

b)

Oxaloacetate

c)

Citrate

d)

Succinate

7.

Pyruvate enters the CAC via conversion to Acetyl-CoA. Acetyl combines with oxaloacetate to create citrate. Citrate can inhibit which enzyme in glycolysis?

a)

Hexokinase

b)

Glucokinase

c)

Phosphofructokinase

d)

Pyruvate kinase

8.

Inside the inner mitochondrial membrane, there are many complexes. Complex III accepts electrons from the Q-protein and what?

a)

FADH2

b)

NADPH

c)

NADH

d)

Pyruvate

9.

Glucose can theoretically yield how much glucose?

a)

30 ATP

b)

32 ATP

c)

36 ATP

d)

38 ATP

10.

The hormones Cortisol and Glucagon affect gluconeogenesis by regulation of what enzyme?

a)

Pyruvate carboxylase

b)

Fructose-1,6-biphosphatase

c)

Phosphoenolpyruvate carboxykinase

d)

Glucose-6-phosphatase

11.

The pentose phosphate pathway is important for creating a molecule that can eliminate toxic oxygen radicals. What molecule is it?

a)

NADH

b)

FADH2

c)

NADPH

d)

Ribulose-5-phosphate

12.

RBC death due to loss of NADPH is caused by which deficiency?

a)

G6PDH

b)

Tay-Sachs

c)

Xeroderma pigmentosa

d)

Diabetes Mellitus

13.

What is the committing enzyme for glycogen synthesis?

a)

Hexokinase

b)

Phoshophofructokinase

c)

Phosphoenolpyruvate carboxykinase

d)

Pyruvate kinase

14.

Glycogen phosphorylase is under the control of epinephrine and glucagon, both which promote activation of which carbohydrate metabolism?

a)

Glycogenolysis

b)

FA synthesis

c)

PPP

d)

Ketone synthesis

15.

The committing step for FA synthesis uses Acetyl-CoA carboxylase to produce which molecule?

a)

Malonyl-CoA

b)

Acetyl-CoA

c)

Bicarbonate

d)

Citrate

16.

Acetyl-CoA carboxylase can be activated by an allosteric modification by which molecule?

a)

Citrate

b)

Succinate

c)

Palmitoyl-CoA

d)

Insulin

17.

Acetyl-CoA Carboxylase can be inactivated by the hormone Glucagon via which enzyme?

a)

Protein kinase

b)

Citrate

c)

Palmitoyl-CoA

d)

Insulin

18.

A F.A. strand that is longer than 12C have to use a special transporter to get into the mitochondria to be degraded. What is the name of the enzyme that removes carnitine?

a)

CPT I

b)

CPT II

c)

translocase

d)

CPT III

19.

FA degradation starts in the cytoplasm and ends in the mitochondria. Once inside the mitochondria it goes through a process called B-oxidation. Acetyl-CoA is created by which enzyme?

a)

Acyl-CoA dehydrogenase

b)

Enoyl-CoA hydratase

c)

L-3-hydroxyacyl-CoA dehydrogenase

d)

B-ketothiolase

20.

Which one is a ketone body?

a)

Acetone

b)

Citrate

c)

Succinyl-CoA

d)

Acetyl-CoA

21.

If you are missing the enzyme B-N-acteylhexosaminidase, you may have which disease?

a)

Tay-Sachs

b)

Xeroderma pigmentosa

c)

G6PDH

d)

Prions

22.

In the committing step of Cholesterol, HMG-CoA reductase is used to create what molecule?

a)

HMG-CoA

b)

Acetoacetate

c)

Mevalonic acid

d)

Squalene

23.

Statins are an important drug for reducing cholesterol in patients. What do statins inhibit?

a)

Acetyl-CoA

b)

Squalene

c)

HMG-CoA reductase

d)

Phosphofructokinase

24.

What binds to ergosterol and causes cell leakage and eventually cell death?

a)

Ionophore

b)

Polyenes

c)

Ca channel blockers

d)

Histamine blockers

25.

If you were having heartburn, you might take a drug named Pantoprazole. This drug would inhibit what?

a)

Ca channels

b)

H2 receptors

c)

Proton pumps

d)

Ionophores

26.

Intracellular steroid receptors can be genomic, affect DNA synthesis. Intracellular steroid receptors would be what group of cell signals?

a)

Group I

b)

Group II

27.

Group II signals have different a-subunits, creating different G-proteins. Which G-protein stimulates phospholipase C?

a)

Gs

b)

Gi

c)

Gq

d)

Gt

28.

Adenylyl cyclase forms the secondary messenger cAMP, which activates what?

a)

DAG

b)

PIP

c)

Phospholipase C kinase

d)

Protein kinase A

29.

DAG and IP3 are created from the cleavage of PIP. The activation of what causes the cleavage?

a)

Protein kinase A

b)

cAMP

c)

Phospholipase C

d)

adenyl cyclase

30.

The secondary messenger IP3 being cleaved from PIP causes the intracellular release of which ion?

a)

Ca

b)

Na

c)

K

d)

Cl

31.

Speciality structures congregate together on the cell membrane to help with cell signaling are called what?

a)

Lipid rafts

b)

Poylenes

c)

Na/K pump

d)

Ionphores

32.

The JAK-STAT mechanism is used to do what?

a)

Activation of Transcription

b)

Activation of Translation

c)

DNA Replication

d)

DNA Mutations

33.

Which strand contains Okazaki fragments?

a)

Leading strand

b)

Lagging strand

34.

Which enzyme cuts the phosphate backbone to untangle DNA strands?

a)

DNA polymerase

b)

Helicase

c)

Topoisomerase

d)

Ligase

35.

At the end of transcription, the addition of several adenine units is known as what?

a)

3’ Poly-A tail

b)

5’ Poly-A tail

c)

3’ cap

d)

5’ cap

36.

HIV is unique in that it can synthesize DNA from RNA, using reverse transcriptase. Which drug is a retroviral?

a)

AZT

b)

Prantoprazole

c)

Timidine

d)

Cyclins

37.

Which ribosome, in humans, establishes the start site for mRNA?

a)

40S

b)

60S

c)

30S

d)

50S

38.

In normal body conditions, larger proteins require help folding into larger protein structures. What helps fold the proteins?

a)

Chaperones

b)

Heat shock proteins

c)

Ribosome

d)

ER

39.

Histones tightly wrap DNA. What enzyme allows RNA polymerase access to the DNA?

a)

Histone deactylase

b)

Histone acetyl transferase

c)

Histone carboxylase

d)

Histone kinase

40.

If a point mutation switches an C for an A, it would be what type of mutation?

a)

Transition

b)

Transversion

c)

Frameshift

d)

Point

41.

What enzyme is involved with sensing incorrect bases in DNA repair?

a)

Endonucleases

b)

Exonucleases

c)

Polymerase

d)

Ligase

42.

What disorder has to do with cyclobutane rings being formed?

a)

Xeroderma pigmentosa

b)

Tay-Sachs

c)

G6PDH

d)

Diabetes Mellitus

43.

What detects DNA damage during the cell cycle?

a)

p53

b)

p21

c)

p16

d)

p27

44.

During which phase of the cell cycle do the cells start to lose cell cycle proteins?

a)

G1

b)

G2

c)

S

d)

G0

45.

During M phase, securin is degraded by what?

a)

anaphase-promoting complex

b)

CDK4

c)

Separase

d)

Mitosis promoting factor

46.

Cancer treatment can be done in different ways. One way is to use Vincristine and Taxol to target what in cancer cells?

a)

Microtubules

b)

Nucleus

c)

RER

d)

Cell Membrane

47.

In a well fed state, High ATP and citrate inhibit phosphofructokinase-1. This causes G6P to do which one of the following?

a)

Glycogenesis

b)

Glcogenolysis

c)

Glycolysis

d)

Gluconeogenesis

48.

If you just ate a large meal and have a high blood glucose level, your body will go into glycogenesis due to which hormone?

a)

Insulin

b)

Cortisol

c)

Glucagon

49.

What means the buildup of molecules?

a)

Anabolism

b)

Catabolism

50.

If you have high levels of energy and Acetyl-CoA, it stimulates pyruvate carboxylase causing pyruvate to go to which carbohydrate metabolism?

a)

Gluconeogenesis

b)

Kreb Cycle

c)

Oxidative Phosphorylation

d)

Ketone Synthesis

51.

During anaerobic respiration pyruvate can be converted to lactate to keep glycolysis going. In the liver, this process is known as what?

a)

Cori cycle

b)

Alanine cycle

c)

Kreb cycle

d)

Ketone cycle

52.

What stimulates lactase dehydrogenase to create lactate in anaerobic skeletal muscles?

a)

Increased NADH levels

b)

Decreased NADH levels

c)

Increased ATP levels

d)

Decreased CO2 levels

53.

During starvation, the brain uses ketone bodies for energy. What molecule do ketone bodies come from?

a)

Acetyl-CoA

b)

Pyruvate

c)

G6P

d)

Glucose

54.

Glucagon acts mainly on the liver to stimulate production of glucose. Where is glucagon produced?

a)

Pancreatic B-cells

b)

Pancreatic A-cells

c)

Prancreatic C-cells

d)

Liver A-cells

55.

Epinephrine and norepinephrine immediately act on regulating metabolism. Theses hormones are classified as _____________.

a)

Catecholamines

b)

Glucocorticoid

c)

Sphingolipids

d)

Triglycerides

56.

Stress stimulates corticotrophin-releasing factors and adrenocorticotropic hormone, which release cortisol. Cortisol increase blood glucose levels by doing what?

a)

Breakdown of muscle protein

b)

Creating cholesterol

c)

Create ketone bodies

d)

Breakdown of fatty acids

57.

Which Diabetes Mellitus is an autoimmune issue and can be treated with injections?

a)

Type 2

b)

Type 1

c)

Type 3

d)

Type 4