Free Printable Med Chem - Mod 3

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Worksheets

Med Chem - Mod 3

Total questions: 40

Worksheet time: 20mins

Name

Class

Date

1.

collection of target species is through database surveillance

a)

Random screening

b)

Selection of specific taxonomic group

c)

Chemotaxonomic approach

d)

Information-managed approach

e)

Ethnobotanical approach

2.

restricted classes of secondary metabolites are sought

a)

Random screening

b)

Selection of specific taxonomic group

c)

Chemotaxonomic approach

d)

Information-managed approach

e)

Ethnobotanical approach

3.

investigating remedies used in traditional medicine

a)

Random screening

b)

Selection of specific taxonomic group

c)

Chemotaxonomic approach

d)

Information-managed approach

e)

Ethnobotanical approach

4.

Process of collecting or surveying a large set of plants or animals for the purpose of evaluation and isolation of lead compounds

a)

Compound Development

b)

Compound Structure Elucidation

c)

Preliminary Biological Screening

d)

Biodiversity Prospecting

5.

assessment whether a given in vitro active compound is active in vivo, and this requires small amounts of test material

a)

METABOLOMICS

b)

BIOASSAY-DIRECTED FRACTIONATION

c)

SECONDARY DISCRIMINATOR ASSAY

d)

DEREPLICATION

e)

COMBINATORIAL BIOSYNTHESIS

6.

Process of isolating pure active constituents from biomass (plants, microbes, marine invertebrates) using chromatography

a)

METABOLOMICS

b)

BIOASSAY-DIRECTED FRACTIONATION

c)

SECONDARY DISCRIMINATOR ASSAY

d)

DEREPLICATION

e)

COMBINATORIAL BIOSYNTHESIS

7.

a contemporary approach with the ability not only to produce new natural product analogues but also to afford new candidates

a)

METABOLOMICS

b)

BIOASSAY-DIRECTED FRACTIONATION

c)

SECONDARY DISCRIMINATOR ASSAY

d)

DEREPLICATION

e)

COMBINATORIAL BIOSYNTHESIS

8.

this method involves engineering of biosynthetic gene clusters

a)

METABOLOMICS

b)

BIOASSAY-DIRECTED FRACTIONATION

c)

SECONDARY DISCRIMINATOR ASSAY

d)

DEREPLICATION

e)

COMBINATORIAL BIOSYNTHESIS

9.

Applied during natural product drug discovery programs to avoid re-isolation of previously determined structure

a)

METABOLOMICS

b)

BIOASSAY-DIRECTED FRACTIONATION

c)

SECONDARY DISCRIMINATOR ASSAY

d)

DEREPLICATION

e)

COMBINATORIAL BIOSYNTHESIS

10.

drug from Penicillium citrinum

a)

Digitoxin

b)

Digoxin

c)

Mevastatin

d)

Lovastatin

e)

Exenatide

11.

drug from Penicillium brevicompactum

a)

Digitoxin

b)

Digoxin

c)

Mevastatin

d)

Lovastatin

e)

Exenatide

12.

drug from Digitalis purpurea

a)

Digitoxin

b)

Digoxin

c)

Mevastatin

d)

Lovastatin

e)

Exenatide

13.

drug from Digitalis lanata

a)

Digitoxin

b)

Digoxin

c)

Mevastatin

d)

Lovastatin

e)

Exenatide

14.

Anticholinergic

a)

Epibatidine

b)

Morphine

c)

Ziconotide

d)

Galanthamine

e)

Atropine

15.

slows neurological degeneration

a)

Epibatidine

b)

Morphine

c)

Ziconotide

d)

Galanthamine

e)

Atropine

16.

Non-opioid analgesic for the amelioration of chronic pain

a)

Epibatidine

b)

Morphine

c)

Ziconotide

d)

Galanthamine

e)

Atropine

17.

Analgesic with lesser addictive properties

a)

Epibatidine

b)

Morphine

c)

Ziconotide

d)

Galanthamine

e)

Atropine

18.

Used to treat bacteria that infect the lungs and sinuses including community-acquired pneumonia caused by S. pneumoniae

a)

Telithromycin

b)

Artemisinin

c)

Biapenem

d)

Quinine

e)

Daptomycin

19.

Bactericidal against Vancomycin-resistant Enterococcus faecalis and E. faecium, complicated skin and dermal infections

a)

Telithromycin

b)

Artemisinin

c)

Biapenem

d)

Quinine

e)

Daptomycin

20.

Vinorelbine

a)

Bisindole alkaloid

b)

Epipodophyllotixin

c)

Taxanes

d)

Camptothecin

21.

Teniposide

a)

Bisindole alkaloid

b)

Epipodophyllotixin

c)

Taxanes

d)

Camptothecin

22.

Topotecan

a)

Bisindole alkaloid

b)

Epipodophyllotixin

c)

Taxanes

d)

Camptothecin

23.

Chemopreventive Agent from broccoli

a)

Curcumin

b)

Epigallocatechin gallate

c)

Trans-resveratrol

d)

D-sulforaphane

24.

Chemopreventive Agent from certain red wine

a)

Curcumin

b)

Epigallocatechin gallate

c)

Trans-resveratrol

d)

D-sulforaphane

25.

Chemopreventive Agent from green tea

a)

Curcumin

b)

Epigallocatechin gallate

c)

Trans-resveratrol

d)

D-sulforaphane

26.

Chemopreventive Agent from turmeric

a)

Curcumin

b)

Epigallocatechin gallate

c)

Trans-resveratrol

d)

D-sulforaphane

27.

source of Tacrolimus

a)

Streptomyces tsukubaensis

b)

Streptomyces hygroscopicus

c)

Streptomyces roseosporus

d)

Streptomyces cattleya

28.

source of Tigecycline

a)

Streptomyces tsukubaensis

b)

Streptomyces hygroscopicus

c)

Streptomyces roseosporus

d)

Streptomyces cattleya

29.

source of Daptomycin

a)

Streptomyces tsukubaensis

b)

Streptomyces hygroscopicus

c)

Streptomyces roseosporus

d)

Streptomyces cattleya

30.

source of Everolimus

a)

Streptomyces tsukubaensis

b)

Streptomyces hygroscopicus

c)

Streptomyces roseosporus

d)

Streptomyces cattleya

31.

pure bioactive compounds are evaluated mechanistically for their effects on a particular biological target, stage of the life cycle of a pathogen

a)

Collection of Source Organism

b)

Preparation of Initial Extracts

c)

Preliminary Biological Screening

d)

Compound Structure Elucidation and Identification

e)

Compound Development

32.

once a led product is obtained in gram quantities, it is subjected to pre-clinical and clinical trials for pharmaceutical optimization

a)

Collection of Source Organism

b)

Preparation of Initial Extracts

c)

Preliminary Biological Screening

d)

Compound Structure Elucidation and Identification

e)

Compound Development

33.

selection of plant sample may be based on specific taxonomic groups, by family or genus

a)

Collection of Source Organism

b)

Preparation of Initial Extracts

c)

Preliminary Biological Screening

d)

Compound Structure Elucidation and Identification

e)

Compound Development

34.

In order for other researchers to access an obtained sample, biodiversity prospecting of a material can be done through this:

a)

deposit sample in an herbarium

b)

extraction of sample using methanol or ethanol

c)

isolation of pure active constituent by chromatographic techniques

d)

dereplication of natural drug product

35.

source of sample for pharmacognosy study can be obtained from these, except:

a)

plant

b)

animal

c)

microorganism

d)

mineral

e)

water

36.

Which of these samples produce a sympathetic effect?

a)

deadly nightshade

b)

marijuana

c)

pit viper

d)

leech

e)

lizard

37.

These are the medical benefits of marijuana, except:

a)

euphoriant

b)

treatment of N&V for cancer patients

c)

alleviation of neuropathic pain

d)

treatment of spasms in patients with multiple sclerosis

38.

Digoxin adn digitoxin produce this cardiac effect:

a)

positive inotropic effect

b)

positive chonotropic effect

c)

negative inotropic effect

d)

negative chonotropic effect

39.

Which of these drugs is not used for resistant strains of bacteria?

a)

telithromycin

b)

daptonomycin

c)

biapenem

d)

carbapenem

40.

Which of the following botanical dietary supplement has both beneficial and toxic effect?

a)

st. John's wort

b)

valerian

c)

evening primrose

d)

milk thistle

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