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WorksheetsPathology
Total questions: 50
Worksheet time: 25mins
Name
Class
Date
1.
Which finding on electron microscopy indicates irreversible cell injury?
a)
Dilatation of endoplasmic reticulum
b)
Dissociation of ribosomes from rough large endoplasmic reticulum
c)
Large flocculent amorphous densities in the mitochondria
d)
Myelin figures
2.
All are reversible injury of cell except
a)
Vacuole
b)
Karyorrhexis
c)
Fat accumulation
d)
Cell wall sweling
3.
In cell death myelin figures are derived from
a)
Nucleus
b)
Cell membrane
c)
Cytoplasm
d)
Mitochondria
4.
All of the following statements are true regarding reversible cell injury except
a)
Formation of large amorphous densities in the mitochondrial matrix
b)
Diminished generation of ATP
c)
Formation of blebs in plasma membrane
d)
Detachment of ribosomes from the granular endoplasmic reticulun
5.
The Fenton reaction leads to free radical generation when
a)
Radiant energy is absorbed by water
b)
Hydrogen peroxide is formed by myeloperoxidase
c)
Ferrous ions are converted to ferric ions
d)
Nitric oxide is converted to peroxynitrite anion
6.
Fibrinoid necrosis is seen in the following except
a)
PAN
b)
Diabetes mellitus
c)
Malignant hypertension
d)
SLE
7.
Eosinophilia in necrosed tissue is due to
a)
Coagulation of proteins
b)
Denaturation of enzymes
c)
Lysosomal damage
d)
Mitochondrial damage
8.
Type of necrosis occuring in brain
a)
Coagulative
b)
Liquefactive
c)
Fibrinoid
d)
Caseous
9.
In Myocardial infarction, the type of necrosis seen is
a)
Coagulative necrosis
b)
Liquefactive necrosis
c)
Caseous necrosis
d)
Fat necrosis
10.
Cause for caseous necrosis in TB
a)
Hydrolytic enzymes
b)
Mycolic acid
c)
High lipid content
d)
Hydropic changes done by bacterial cell wall
11.
Fat necrosis is common in
a)
Omentum
b)
Breast
c)
Retroperitoneal fat
d)
All of the above
12.
Type of necrosis in pancreatitis
a)
Fibrinoid
b)
Coagulative
c)
Fat
d)
Caseous
13.
Coagulative necrosis is seen in all except
a)
Myocardia infarction
b)
Tuberculosis
c)
Thermal injury
d)
Zenker's degeneration
14.
Programmed cell death is known as
a)
Cytolysis
b)
Apoptosis
c)
Necrosis
d)
Proptosis
15.
The characteristic feature of apoptosis on light microscopy is
a)
Cellular swelling
b)
Nuclear compaction
c)
Intact cell membrane
d)
Cytoplasmic eosinophilia
16.
True about apoptosis is all except
a)
Inflammation is present
b)
Chromosomal breakage
c)
Clumping of chromatin
d)
Cell shrinkage
17.
Apoptotic bodies are
a)
Clumped chromatin bodies
b)
Pyknotic nucleus without organelles
c)
Cell membrane bound organelles
d)
No nucleus with organelles
18.
Steatosis means
a)
Fatty change
b)
Accumulation of proteins
c)
Accumulation of glycogen
d)
Accumulation of pigment
19.
Brown atrophy is due to accumulation of
a)
Melanin
b)
Hemosiderin
c)
Hematin
d)
Lipofuscin
20.
Dystrophic calcification is seen in
a)
Milk alkali syndrome
b)
Atheromatous plaque
c)
Hyperparathyroidism
d)
Vitamin A intoxication
21.
Metastatic calcification is most often seen in
a)
Lymph nodes
b)
Lungs
c)
Spleen
d)
Liver
22.
True about metastatic calcification
a)
Serum calcium level is normal
b)
Occurs in dead/dying tissue
c)
Occurs in damaged heart valves
d)
Calcification starts in mitochondria
23.
True about psammoma bodies are all except
a)
Seen in meningioma
b)
Concentric whorled appearance
c)
Contains calcium deposits
d)
Seen in teratoma
24.
Calcification of soft tissues without any disturbance of calcium metabolism is called
a)
Ionotropic calcification
b)
Monotropic calcification
c)
Dystrophic calcification
d)
Calcium induced calcification
25.
Which of the following is not a common site for metastatic calcification?
a)
Gastric mucosa
b)
Kidney
c)
Parathyroid
d)
Lung
26.
Dystrophic calcification means
a)
Calcification in dead & degenerated tissue with normal calcium level in blood
b)
Increased level of calcium deposits
c)
Calcification in normal tissue seen in hyperparathyroidism
d)
Calcification in dead & degenerated tissues with hypercalcemia
27.
Pyogenic infection and brain infarction associated with
a)
Coagulative necrosis
b)
Liquefactive necrosis
c)
Caseous necrosis
d)
Fat necrosis
28.
Most common type of necrosis which results from sudden occlusion of blood supply
a)
Coagulative necrosis
b)
Caseous necrosis
c)
Liquefactive necrosis
d)
Gangrene
29.
Intracellular calcification begin in the
a)
Mitochondria
b)
Endoplasmic reticulum
c)
Golgi bodies
d)
Intracellular vacuoles
30.
Cloudy swelling is due to
a)
Accumulation of glycogen intracellularly
b)
Fat accumulation intracellularly
c)
Lysozyme degeneration
d)
Accumulation of water intracellularly
31.
Classical signs of inflammation are all except
a)
Pain
b)
swelling
c)
cyanosis
d)
redness
32.
Rubor in inflammation is due to
a)
dilatation of arterioles
b)
oedema
c)
increased vascular permeability
d)
Increased viscocity of blood
33.
The following host tissue response can be seen in acute inflammation except
a)
exudation
b)
vasodilatation
c)
margination
d)
granuloma formation
34.
Earliest transient change following tissue injury will be
a)
neutrophilia
b)
monocytosis
c)
lymphocytosis
d)
basophilia
35.
Granuloma is a microscopic aggregation of
a)
neutrophils
b)
activated macrophages
c)
NK-cells
d)
cytotoxic T-cells
36.
what is not caused by platelet activating factor
a)
vasoconstriction
b)
bronchodilatation
c)
platelet aggregation
d)
transmission of signals between cells
37.
Increased capillary permeability is caused by all of the following except
a)
anaphylotoxin
b)
5-hydroxytryptamine
c)
renin
d)
histamine
38.
Actions of bradykinin include all of the following except
a)
vasodilatation
b)
increased vascular permeability
c)
pain
d)
bronchodilatation
39.
All of the following statements are correct about thrmboxane except
a)
secreted by WBC
b)
low dose aspirin inhibits its synthesis
c)
causes vasoconstriction in blood vessels
d)
causes bronchoconstriction
40.
Oxygen dependent killing is done through
a)
superoxide dismutase
b)
NADPH oxidase
c)
catalase
d)
glutathione peroxidase
41.
Major basic protein is formrd by
a)
neutrophil
b)
lymphocyte
c)
basophil
d)
eosinophil
42.
Which cytokine activate macrophages
a)
IL-B
b)
IFN ϒ
c)
PAF
d)
LeukotrieneB4
43.
prostacyclin is mainly produced by
a)
eosinophil
b)
mast cell
c)
vascular endothelium
d)
platelet
44.
Lifespan of neutrophil is
a)
6 hours
b)
15 days
c)
5 days
d)
48 hours
45.
Chemical mediator causing vasoconstriction is
a)
prostacyclin
b)
thromboxane A2
c)
PGD2
d)
Lipoxins
46.
All of the following are true about serous inflammation except
a)
A pattern of acute inflammation
b)
Fluid does not contain large number of cells
c)
Fluid contain increased amount of protein
d)
Fluid is not infected by microrganisms
47.
the process which boosts the ability of phagocytic cell to carry out phagocytosis is called
a)
cross reactivity
b)
immune tolerance
c)
Immune surveillance
d)
opsonisation
48.
Epithelioid cell is a modified
a)
lymphocyte
b)
macrophage
c)
mast cell
d)
eosinophil
49.
when the leukocytes are arranged along the endothelium of the vessel;it is called
a)
diapedesis
b)
adhesion
c)
chemotaxis
d)
margination
50.
Langhans giant cell is seen in
a)
tuberculosis
b)
xanthoma
c)
hodgkins lymphoma
d)
syphilis
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