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Germ cell & sex cord stromal tumors of ovary

Total questions: 30

Worksheet time: 29mins

Name
Class
Date
1.

Choose the correct statement

a)

Adult germ cell tumors are malignant

b)

Teratomas arise from the ovum after second meiotic division

c)

Extragonadal teratomas arise from midline embryonic rests

d)

Teratomas always contain cells derived from all 3 germ layers

2.

A lady got diagnosed with a mass in her abdomen and it was taken out of her ovary. The tumor turned out to be a cyst which contained buttery sebaceous yellow material with few hairs. Microscopic analysis will reveal differentiation mainly along:

a)

Endodermal line

b)

Ectodermal line

c)

Mesodermal line

d)

Embryonic cell line

3.

Rokitansky nodules are covered with hair protruding into the outside of the ovary and shows the greatest variety of 3 germ cell tissue types

a)

True

b)

False

4.

Complications of dermoid cyst are all except:

a)

Limbic encephalitis

b)

Torsion

c)

Infertility

d)

Endometriosis

5.

Carcinomas associated with dermoid cyst:

a)

Melanoma

b)

Carcinoid tumor

c)

Basal cell carcinoma

d)

Small cell carcinoma

6.

Mature solid teratomas and immature teratomas are similar in gross appearance

a)

True

b)

False

7.

A solid tumor showing necrosis, hemorrhage and heterogeneous mixture of various tissues would reveal on microscopy:

a)

Neuroepithelial rosettes

b)

Mature glial tissue

c)

Rokitansky nodules

d)

Hyaline droplets

8.

A woman presented with thyrotoxicosis but examination revealed a normal thyroid. The possible condition is:

a)

Monodermal teratoma

b)

Small cell carcinoma lung

c)

Dermoid cyst

d)

Choriocarcinoma

9.

Pseudohermaphroditism is an important risk factor for:

a)

Granulosa cell tumor

b)

Endodermal sinus tumor

c)

Dysgerminoma

d)

Embryonal carcinoma

10.

Encapsulated malignancy of ovary:

a)

Dysgerminoma

b)

Choriocarcinoma

c)

Yolk sac tumor

d)

Fibroma

11.

The microscopy of an ovarian tumor revealed lymphocytic infiltration in the fibrotic stroma. The appropriate statement is:

a)

They are mainly B cells

b)

Mitotic figures are not seen in tumor cells

c)

Glycogen filled cytoplasm in tumor cells

d)

Nuclei contain coarse chromatin

12.

Dysgerminoma spreads to contralateral ovary through

a)

Local spread

b)

Lymphatics

c)

Blood

d)

Transperitoneal

13.

5 year survival rate for stage 1 dysgerminoma patients :

a)

70%

b)

90%

c)

100%

d)

50%

14.

True statement about yolk sac tumor:

a)

Differentiation of malignant extrambryonic sex cord cells

b)

AFP and α₁- antitrypsin in serum

c)

Slow growing tumor

d)

Seen in young women

15.

Schiller duval bodies are glomerulus like structures containing central blood vessel enveloped by germ cells in normal ovarian stroma

a)

True

b)

False

16.

Hyaline droplets seen in yolk sac tumors are positive for:

a)

AFP

b)

PAS

c)

hCG

d)

ALP

17.

Which of the following is absent in choriocarcinoma?

a)

Cytotrophoblast

b)

Hemorrhage

c)

Chorionic villi

d)

hCG

18.

Adult granulosa cell tumors are composed of

a)

Granulosa cells

b)

Theca cells

c)

Fibroblast

d)

All of these

19.

Tumor seen in postmenopausal women

a)

Granulosa cell tumor

b)

Yolk sac tumor

c)

Choriocarcinoma

d)

Embryonal carcinoma

20.

Hormonally active tumors:

a)

Yellow color

b)

Extracellular lipids

c)

Grey color

d)

Leydig cell tumor

21.

Pattern not seen in granulosa cell tumor:

a)

Sarcomatoid

b)

Insular

c)

Trabecular

d)

Glandular

22.

Select the false statement about the following structure :

a)

Filled with acidophilic material

b)

Degenerative space

c)

Seen in majority of tumors

d)

Very useful for diagnosis

23.

Select the true statement regarding granulosa cell tumor:

a)

Reticulin stain positivity seen in stromal regions

b)

High grade tumor

c)

Inhibin is a specific marker used in both immunohistochemistry and biochemistry

d)

Cells are large & columnar with coffee bean nuclei

24.

Gene mutation important in granulosa cell tumor:

a)

FOXL2

b)

OCT3

c)

KIT

d)

ARID1A

25.

Plump spindle cells with lipid droplets are seen in:

a)

Fibroma

b)

Thecoma

c)

Granulosa cell tumor

d)

Krukenberg tumor

26.

Basal cell nevus syndrome is associated with:

a)

Fibroma

b)

Thecoma

c)

Granulosa cell tumor

d)

All of these

27.

A woman presented with a right hydrothorax, ascites and pelvic mass. The microscopy of the mass would reveal:

a)

Scant collagenous connective tissue

b)

Call-exner bodies

c)

Signet ring cells

d)

Hyaline droplets

28.

Metastatic carcinoma is characterised by:

a)

Bilaterality

b)

Multinodularity

c)

Hormonal activity

d)

Cystic growth

29.

True statement about Krukenberg tumors:

a)

Distortion of ovarian shape

b)

Most common primary is breast

c)

Variegated appearance on cut section

d)

Capsule invaded

30.

The following histology reveals:

a)

Signet ring cells

b)

Dysgerminoma cells

c)

Thyroid follicles

d)

Neuroepithelial rosettes