WorksheetsGerm cell & sex cord stromal tumors of ovary
Total questions: 30
Worksheet time: 29mins
Choose the correct statement
Adult germ cell tumors are malignant
Teratomas arise from the ovum after second meiotic division
Extragonadal teratomas arise from midline embryonic rests
Teratomas always contain cells derived from all 3 germ layers
A lady got diagnosed with a mass in her abdomen and it was taken out of her ovary. The tumor turned out to be a cyst which contained buttery sebaceous yellow material with few hairs. Microscopic analysis will reveal differentiation mainly along:
Endodermal line
Ectodermal line
Mesodermal line
Embryonic cell line
Rokitansky nodules are covered with hair protruding into the outside of the ovary and shows the greatest variety of 3 germ cell tissue types
True
False
Complications of dermoid cyst are all except:
Limbic encephalitis
Torsion
Infertility
Endometriosis
Carcinomas associated with dermoid cyst:
Melanoma
Carcinoid tumor
Basal cell carcinoma
Small cell carcinoma
Mature solid teratomas and immature teratomas are similar in gross appearance
True
False
A solid tumor showing necrosis, hemorrhage and heterogeneous mixture of various tissues would reveal on microscopy:
Neuroepithelial rosettes
Mature glial tissue
Rokitansky nodules
Hyaline droplets
A woman presented with thyrotoxicosis but examination revealed a normal thyroid. The possible condition is:
Monodermal teratoma
Small cell carcinoma lung
Dermoid cyst
Choriocarcinoma
Pseudohermaphroditism is an important risk factor for:
Granulosa cell tumor
Endodermal sinus tumor
Dysgerminoma
Embryonal carcinoma
Encapsulated malignancy of ovary:
Dysgerminoma
Choriocarcinoma
Yolk sac tumor
Fibroma
The microscopy of an ovarian tumor revealed lymphocytic infiltration in the fibrotic stroma. The appropriate statement is:
They are mainly B cells
Mitotic figures are not seen in tumor cells
Glycogen filled cytoplasm in tumor cells
Nuclei contain coarse chromatin
Dysgerminoma spreads to contralateral ovary through
Local spread
Lymphatics
Blood
Transperitoneal
5 year survival rate for stage 1 dysgerminoma patients :
70%
90%
100%
50%
True statement about yolk sac tumor:
Differentiation of malignant extrambryonic sex cord cells
AFP and α₁- antitrypsin in serum
Slow growing tumor
Seen in young women
Schiller duval bodies are glomerulus like structures containing central blood vessel enveloped by germ cells in normal ovarian stroma
True
False
Hyaline droplets seen in yolk sac tumors are positive for:
AFP
PAS
hCG
ALP
Which of the following is absent in choriocarcinoma?
Cytotrophoblast
Hemorrhage
Chorionic villi
hCG
Adult granulosa cell tumors are composed of
Granulosa cells
Theca cells
Fibroblast
All of these
Tumor seen in postmenopausal women
Granulosa cell tumor
Yolk sac tumor
Choriocarcinoma
Embryonal carcinoma
Hormonally active tumors:
Yellow color
Extracellular lipids
Grey color
Leydig cell tumor
Pattern not seen in granulosa cell tumor:
Sarcomatoid
Insular
Trabecular
Glandular
Select the false statement about the following structure :
Filled with acidophilic material
Degenerative space
Seen in majority of tumors
Very useful for diagnosis
Select the true statement regarding granulosa cell tumor:
Reticulin stain positivity seen in stromal regions
High grade tumor
Inhibin is a specific marker used in both immunohistochemistry and biochemistry
Cells are large & columnar with coffee bean nuclei
Gene mutation important in granulosa cell tumor:
FOXL2
OCT3
KIT
ARID1A
Plump spindle cells with lipid droplets are seen in:
Fibroma
Thecoma
Granulosa cell tumor
Krukenberg tumor
Basal cell nevus syndrome is associated with:
Fibroma
Thecoma
Granulosa cell tumor
All of these
A woman presented with a right hydrothorax, ascites and pelvic mass. The microscopy of the mass would reveal:
Scant collagenous connective tissue
Call-exner bodies
Signet ring cells
Hyaline droplets
Metastatic carcinoma is characterised by:
Bilaterality
Multinodularity
Hormonal activity
Cystic growth
True statement about Krukenberg tumors:
Distortion of ovarian shape
Most common primary is breast
Variegated appearance on cut section
Capsule invaded
The following histology reveals:
Signet ring cells
Dysgerminoma cells
Thyroid follicles
Neuroepithelial rosettes
