WorksheetsBIOPHARMACEUTICS & PHARMACOKINETICS
Total questions: 30
Worksheet time: 7hrs 16mins
The rate and extent to which active drug reaches systemic circulation is known as
Biotranformation
Bioavailability
Steady state plasma concentration
Peak plasma concentration
The science that examines the inter-relationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on drug’s bioavailability
Pharmacology
Biopharmaceutics
Toxicology
Pharmacokinetics
The branch of pharmacology that deals with disposition and fate of drug is
both
pharmacokinetics
pharmacodynamics
none
Which of the following statement is (are) correct?
pharmacodynamic parameters characterize the effects of a drug on the body
pharmacokinetic parameters describe the effects of the body on a drug
a receptor is that component of the body with which a drug interacts to produce its effects
none of the above
all of the above
Is the delivery of the active ingredient from a dosage form into solution
Drug release
Absorption
Distribution
Metabolism
Excretion
The effect of reduced particle size of a drug is;
increased absorption
increased disintegration
increased hardness
all
The equation that best describe the overall rate of drug dissolution
Henderson-Hasselbaclh equation
Michelis-Menten equation
Noyes-Whitney equation
Fick’s First Law of Difussion
Dissolution rate is increased by;
decreased in surface area
decrease in particle size
the formation of molecular aggregates
all
The lipid phase which is usually employed in the determination of apparent partition coefficient
water
corn oil
cottonseed oil
octanol
buffer solution at pH 7.4
With decreasing oil/water partition coefficient, the polarity of drug;
increases
decreases
no change
polarity is not related to solubility
The extent of ionization of a weak electrolyte drug is dependent on the
pH of the media and pKa of the drug
particle size and surface area of the drug
oil:water partition coefficient of the drug
Noyes Whitney equation of the drug
polymorphic form of the drug
Most drugs are
strong electrolytes
non-electrolytes
weak electrolytes
highly ionic
None of the above, because many drugs are either weak acids or weak bases
Significant site of absorption of many acidic and neutral compounds but not for basic compounds
kidney
stomach
liver
all
Weak acids are greatly unionized at
high pH
low pH
neutral pH
all
The excretion of weak acid will be more rapid in alkaline urine than in acidic urine because
all drugs are excreted in alkaline urine
he drug will exist primarily in the unionized form
he drug will exist primarily in the ionized form
weak acids cannot be reabsorbed from the kidney tubules
Weak bases are greatly ionized at
high pH
low pH
neutral pH
all
Introduction of salts increases
lipophilic property
hydrophilic property
solubility in nonpolar solvents
none
These are formed when a substance is capable of forming channels or cages which can take up another substance into the intraspace of the structure
co-precipitates
solvates
drug-clathrate complexes
hydrates
An agent that take up another substance into its intraspace structure is called
macromolecular carriers
hydrates
polymorphs
clathrate forming agents
The property of absorbing moisture from the atmosphere include
micronization
hygroscopicity
viscosity
ionization
Which of the following types of dosage form does not require dissolution prior to absorption
tablet
suspension
parenteral solutions
modified dosage form
capsules
Which of the following properties of surfactants tend to increase the rate of dissolution?
surface tension lowering effect
increased surface tension
absence of peptizing action
all
Which of the following is the first process that must occur before a drug can become available for GI absorption from a tablet dosage form?
dissolution of the drug in the GI fluids
ionization of the drug
disintegration of the tablet
dissolution of the drug in the blood
adsorption of the drug on the mucosal surface of the skin
In general, the form of a drug that can be absorbed faster is ;
Ionized form
Unionized form
Bound form
Due to their anatomical structure, the organ that is considered as the most important site of drug absorption is
large intestine
stomach
small intestine
mucous membrane of the mouth
rectum
The lesser the gastric emptying time, the faster the gastric emptying rate
TRUE
FALSE
ERRONEOUS
NOT VALID
The rate of diffusion of drugs across biological membranes is most commonly
independent on the concentration gradient
directly proportional to the concentration gradient
dependent on the availability of carrier substrate
dependent on the route of administration
The driving force for passive absorption of a drug is the;
specific carrier proteins and shows saturation kinetics
concentration gradient across a membrane separating body compartment
BOTH
NONE
In the diffusion controlled system, the initial rate of dissolution is directly proportional to the;
pKa
pH
quantity of free acid
solubility of the drug in the dissolution medium
The transfer of most drugs across biologic membranes occurs by ;
Passive diffusion
Active transport
Facilitated transport
Pinocytosis
Ion-pair transport
