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Worksheetscritical care medicine
Total questions: 10
Worksheet time: 10mins
Nondepolarizing muscle relaxant that has short duration of action, no active metabolites, and has elimination route/metabolism through plasma cholinesterase.
a. Atracurium
b. mivacurium
c. cisatracurium
d. vecuronium
Neuromuscular blocking agents are the first line agents for managing undesired movement, agitation, or ventilator asynchrony. NMBAs may be used for overt shivering due to therapeutic hypothermia following cardiac arrest.
a. First statement is true. Second statement is false.
b. First statement is false. Second statement is true.
c. Both statements are true.
d. Both statements are false.
Drug that undergoes spontaneous degradation via Hoffman elimination.
a. Succinylcholine
b. aminosteroid compound
c. benzylisoquinolinium compound
d. none of the above
Doses of NMBAs’ are increased in burn patients because of:
a. increased protein binding
b. up-regulation of receptors
c. enhanced renal and hepatic elimination
d. All the above
These drugs are preferred for patients with renal insufficiency.
a. Atracurium and vecuronium
b. Pancuronium and cisatracurium
c. Atracurium and cisatracurium
d. Pancuronium and vecuronium
Magnesium reduces duration of neuromuscular blockade. Hypercalcemia may reduce sensitivity to NMBA and increase duration of neuromuscular blockade.
a. First statement is true. Second statement is false.
b. First statement is false. Second statement is true.
c. Both statements are true.
d. Both statements are false.
NMBAs are the most common cause of anaphylaxis (IgE-mediated) in the perioperative period with _____________ being the most frequent agents implicated.
a. succinylcholine and rocuronium
b. atracurium and cisatracurium
c. mivacurium and pancuronium
d. atracurium and rocuronium
For critically ill patients on NMBA infusions, the targeted depth of blockade should be assessed with PNS every _______ until the NMBA dose is stable, then every _________.
a. 2 to 3 hours; 12 to 16 hours
b. 1 to 2 hours; 6 to 8 hours
c. 1 to 2 hours; 8 to 10 hours
d. 2 to 3 hours; 8 to 12 hours
Propofol is a highly lipophilic phenol derivative that is insoluble in water. Propofol has amnesic, anxiolytic, anticonvulsant, and muscle relaxant (including bronchodilation) effects.
a. First statement is true. Second statement is false.
b. First statement is false. Second statement is true.
c. Both statements are true.
d. Both statements are false.
Propofol-related infusion syndrome is generally associated with high doses (>4 mg/kg per hour or >67 mcg/kg per minute) and prolonged use >48 hours. Characteristics of PRIS include acute refractory bradycardia, severe metabolic alkalosis, cardiovascular collapse, rhabdomyolysis, hyperlipidemia, renal failure, and hepatomegaly.
a. First statement is true. Second statement is false.
b. First statement is false. Second statement is true.
c. Both statements are true.
d. Both statements are false.
