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HEMATOLOGY - 2

Total questions: 20

Worksheet time: 15mins

Name
Class
Date
1.

A blood donation camp is arranged in the city of Kanpur on 1st September. A 20 year old young with body weight of 60 kg, wishes to donate blood in the camp. Your chief has asked you to collect his blood in the bag shown below. How much blood would you collect and what should be the date of expiry to be written on the bag?

a)

350 ml, 22nd September

b)

350 ml, 06th October

c)

450 ml, 22nd September

d)

450 ml, 06th October

2.

The following cell is seen in all except:

a)

Myelofibrosis

b)

Fanconi Syndrome

c)

Myelodysplastic syndrome

d)

Hairy Cell Leukemia

3.

A 27 year old man came to the medicine unit with complaints of fever, fatigue and sore throat after his honeymoon. Lymphadenopathy is present. The peripheral smear examination is as shown below. What is likely agent responsible for this presentation?

a)

HHV 1

b)

HHV 2

c)

HHV 3

d)

HHV 4

4.

Genetic mutation associated with the above disease is:

a)

4-alpha gene

b)

3-alpha gene

c)

2-alpha gene

d)

1-alpha gene

5.

How many of these conditions is positive for the stain shown in the image shown?

a: HIV-induced encephalopathy

b: Hairy cell leukemia

c: Gaucher's disease

d: Osteoclastoma

e: Fibrous dysplasia

a)

1

b)

2

c)

3

d)

4

e)

5

6.

Which of these is to be used for cross matching ?

a)

A

b)

B

c)

C

d)

D

7.

A 38 year old man came with weakness and loss of appetite. On examination, he has massive splenomegaly. The blood counts and peripheral smear is as given above. Which of these is the investigation of choice to reach the diagnosis?

a)

Flow cytometry

b)

FISH

c)

IHC

d)

Bone marrow biopsy

8.

Identify the cell shown in the image below:

a)

Lymphoblast

b)

Myeloblast

c)

Myelocyte

d)

Lymphocyte

9.

Best screening test for a clotting factor deficiency?

a)

Clotting factor assay

b)

RFLP

c)

Mixing test

d)

D-Dimer test

10.

A newborn baby has umbilical stump bleeding. PT and aPTT are within normal limits. The flow cytometry analysis is as shown. Diagnosis?

a)

Factor X deficiency

b)

Glanzmann Thrombasthenia

c)

Bernard-Soullier’s disease

d)

Von Willebrand’s disease

11.

Identify the cell

a)

Burr cell

b)

Codocyte

c)

Degmacyte

d)

Spurr cell

12.

‘ABVD Regime’ is used for the treatment of :

a)

Hodgkin’s Lymphoma

b)

Non-Hodgkin’s Lymphoma

c)

Hairy cell Leukemia

d)

Polycythemia vera

13.

A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?

a)

Vincristine

b)

Actinomycin-D

c)

Cyclophosphamide

d)

6-Mercaptopurine

14.

Ramesh, a young male with AML was started on doxorubicin based chemotherapy. Two months later, he presented with swelling of feet and breathlessness on exertion. Which of the following adverse effect of doxorubicin could lead to these symptoms?

a)

Restrictive cardiomyopathy

b)

Hypertrophic cardiomyopathy

c)

Dilated cardiomyopathy

d)

Pericardial fibrosis

15.

Thalidomide was once used for treating emesis of pregnancy. Later it was withdrawn from market due

to side effects. All of these are the side effects of thalidomide except:

a)

Hypothyroidism

b)

Diarrhoea

c)

Phocomelia

d)

Deep vein thrombosis

16.

A child suffering from Iron deficiency anemia is on oral iron therapy. When will the peak reticulocytosis anticipated after starting oral iron?

a)

2-3 days

b)

3-5 days

c)

5-7 days

d)

10-14 days

17.

A 12 year old male patient presented with severe pain in right hip joint. Section of femur head showed the following. What is the most common organism likely to infect the bone in this disease?

a)

Staphylococcus

b)

Salmonella

c)

Eikenella

d)

Pseudomonas

18.

Which of these is not a component of Pearson Syndrome?

a)

Sideroblastic Anemia

b)

Pancytopenia

c)

Endocrine pancreatic dysfunction

d)

Renal tubular acidosis

19.

•A 30 year old lady with history of 3 spontaneous abortions, her mother died of pulmonary embolism and her brother had a DVT at the age of 21 years. Which of these is the correct investigation to identify the cause?

a)

Anticardiolipin antibody positive at 2 occasions and 3 weeks apart

b)

Lupus anticoagulant positive at 2 occasions and 6 weeks apart

c)

Lupus anticoagulant positive at 2 occasions and 3 weeks apart

d)

Anticardiolipin antibody positive at single occasion

20.

True about Gray Platelet Syndrome :

a)

Absence of Alpha granules

b)

Absence of Delta granules

c)

Enhanced platelet aggregation with ristocetin

d)

Premalignant syndrome