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1 midterm осень 20-21

Total questions: 50

Worksheet time: 37mins

Name
Class
Date
1.

Lack of vitamin ... leads to dryness and crackling of human skin, damage to the intestinal mucosa, epithelium of the genitourinary system and respiratory apparatus.

a)

К

b)

А

c)

С

d)

Д

e)

Е

2.

Avitaminosis ... leads to disruption of oxidation-reduction reactions, growth arrest, severe hair loss, inflammatory processes of the mucous corners of the mouth, tongue, lips.

a)

filohinone

b)

cobalamin

c)

thiamine

d)

pyridoxine

e)

riboflavin

3.

Biomembrane proteins DO NOT perform ... function.

a)

carbohydrate forming

b)

carbohydrate forming

c)

receptor

d)

enzymatic

e)

transport

4.

Acidic medium is formed with the participation of an enzyme ....

a)

Ca2 + - ATPase

b)

H + - ATPase

c)

Mg2 + - ATPase

d)

adenylate cyclases

e)

Na +, K + - ATPase

5.

In folding ... refer to proteins exhibiting enzymatic properties.

a)

nuclease

b)

hydrolases

c)

chaperones

d)

polymerases

e)

histones

6.

Molecules involved in protein folding are called ....

a)

coenzyme folding

b)

folding repressors

c)

folding amplifiers

d)

folding regulators

e)

suppressors of folding

7.

The molecular form of proteins is determined ....

a)

enzymes for the synthesis of amino acids and proteins

b)

temperature and humidity

c)

amino acid sequence and temperature

d)

amino acid sequence and folding factors

e)

folding factors and humidity

8.

To the heat shock protein refers ....

a)

p53

b)

Cdk

c)

Sh-40

d)

TGF-β

e)

MCP-1

9.

From metabolites of the cycle of tricarboxylic acids (Krebs cycle) with the participation of transaminase is synthesized ....

a)

tyrosine

b)

tyrosine

c)

serine

d)

glycine

e)

glutamate

10.

Hypoglycemia in the blood arises from the congenital insufficiency of the enzyme ....

a)

glucose-6-phosphate dehydrogenase

b)

glycogen phosphorylase

c)

alpha-amylase

d)

gamma-amylase

e)

lysosomal glycosidase

11.

Disruption ... in the metabolism of carbohydrates leads to the development of symptoms of the diseases of Girke and Mac-Ardle.

a)

glycogenesis

b)

glycolysis

c)

glycogenolysis

d)

gluconeogenesis

e)

pentose phosphate cycle

12.

Hydrolysis of starch in the upper part of the intestine occurs under the action of ....

a)

pancreatic amylase

b)

pancreatic lipase

c)

pancreatic nuclease

d)

pancreatic trypsin

e)

pancreatic phospholipase

13.

Deficiency of fructose - 1,6-bisphosphatase leads to a violation of ....

a)

glycogenolysis

b)

pentose phosphate pathway

c)

glycogenogenesis

d)

gluconeogenesis

e)

glycolysis

14.

When diabetes is observed ....

a)

formation in muscle glycogen with a small number of branch points

b)

reduction in the amount of glycogen in the liver

c)

an increase in the amount of glycogen in the liver

d)

increase in the amount of glycogen in the muscles

e)

the formation in the liver of glycogen with a small number of branch points

15.

Reaction of substrate phosphorylation in the Krebs cycle is:

a)

Succinyl-CoA → succinate

b)

citrate → isocitrate

c)

citrate → isocitrate

d)

fumarate → malate

e)

malate → oxaloacetate

16.

The activity of pyruvate dehydrogenase complex suppresses ....

a)

ADP

b)

NADPF

c)

AMF

d)

FAD

e)

acetyl-CoA

17.

The reaction rate of the Krebs cycle decreases with ....

a)

Effects of force on the muscles

b)

increase in the concentration of ADP

c)

increase in ATP concentration

d)

increasing the concentration of NAD +

e)

increase of Ca2 +

18.

The organospecific enzyme secreting glucose into the blood is:

a)

phosphoglucomutase

b)

phosphofructokinase

c)

glycogen phosphorylase

d)

glucose-6-phosphatase

e)

protein kinase

19.

Potassium cyanide is a poisonous substance that leads to sudden death, it acts on ... in mitochondria.

a)

NAD + - dependent dehydrogenases

b)

cytochrome oxidase

c)

flavin enzymes

d)

cytochrome - P - 450

e)

cytochrome B5

20.

An employee of a chemical enterprise with signs of poisoning entered the hospital. In the hair of this woman found an increased concentration of arsenate, which blocks lipoic acid. The cause of poisoning is a violation of the process ....

a)

recovery of methaemoglobin

b)

microsomal oxidation

c)

microsomal oxidation

d)

recovery of organic peroxides

e)

oxidative decarboxylation of pyruvate

21.

Lactic acid, formed as a result of anaerobic glycolysis during the intensive work of muscles, is used in the process of ....

a)

gluconeogenesis in the liver

b)

synthesis of fatty acids in tissues

c)

excretion of uric acid

d)

synthesis of amino acids in the muscles

e)

synthesis of ketone bodies in tissues

22.

At low physical exertion and excessive consumption of carbohydrates, the synthesis of triacylglycerol in adipose tissue and liver increases with the use of the metabolite of glycolysis:

a)

pyruvate

b)

dihydroxyacetone phosphate

c)

glucose-6-phosphate

d)

acetyl-CoA

e)

glucose-1-phosphate

23.

The common path of catabolism -

a)

the oxidative decarboxylation reaction of pyruvate and the citrate cycle.

b)

transamination and deamination of amino acids.

c)

gluconeogenesis.

d)

glycolysis.

e)

betta - oxidation of fatty acids.

24.

With a common path of catabolism, ...

a)

oxygen scavengers.

b)

hydrogen donors, necessary for electron transport in the mitochondrial chain.

c)

AMF.

d)

oxides of nitrogen.

e)

cyanides.

25.

The primary electron acceptors in the respiratory chain are:

a)

NAD or FAD

b)

NAD or ubiquinone

c)

FAD or cytochrome oxidase

d)

FMN or ubiquinone

e)

NAD, FAD or cytochrome oxidase

26.

The source of glucose in the blood is NOT:

a)

carbohydrates food

b)

synthesis of glucose from pyruvate, lactate

c)

synthesis of glucose from glycerin, amino acids

d)

muscle glycogen

e)

liver glycogen

27.

Under normal conditions carbohydrates are absorbed in the form:

a)

disaccharides

b)

oligosaccharides

c)

polysaccharides

d)

monosaccharides

e)

phosphoric esters of monosaccharides

28.

Oxidizing to the final products of metabolism, carbohydrates perform ... a role.

a)

construction

b)

protective

c)

energy

d)

regulatory

e)

plastic

29.

The process of glycolysis proceeds in ...

a)

mitochondria.

b)

cytosol cells.

c)

cell nucleus.

d)

lysosomes.

e)

ribosomes.

30.

The Krebs cycle proceeds in ...

a)

ribosomes.

b)

cell nucleus.

c)

mitochondria.

d)

cytosol cells.

e)

the Golgi apparatus.

31.

Fibrillar protein is NOT:

a)

collagen

b)

myoglobin

c)

keratin

d)

elastin

e)

myosin

32.

A glycoprotein is a protein containing in its composition ...

a)

lipid.

b)

phosphoric acid.

c)

carbohydrate.

d)

metal.

e)

nucleotide.

33.

Protective function performed in the body ...

a)

amylase.

b)

enzymes.

c)

immunoglobulins.

d)

building proteins.

e)

spare proteins.

34.

At the isoelectric point, the protein ...

a)

is an anion.

b)

is a cation.

c)

possesses a charge.

d)

has the lowest solubility.

e)

has maximum mobility in an electric field.

35.

In the formation of the tertiary structure of the protein molecule involved all the connections and interactions, with the exception of ...

a)

ionic.

b)

coordination.

c)

hydrogen.

d)

hydrophobic.

e)

disulfide.

36.

Dialysis is conducted to:

a)

obtain isoenzymes

b)

to reveal reactive groups of proteins

c)

activation of coenzymes

d)

control and standardization of proteins

e)

to separate proteins from low molecular weight salts

37.

The tetrapeptide formed by alanine-valine-proline-tyrosine will have the following name:

a)

alanylvalylprolyltyrosine

b)

valyltyrosylalanylproline

c)

tyrosylpropylalanylvaline

d)

spillylalanyltyrozine

e)

alanine valvalprolinhyrosyl

38.

The primary structure of the protein is:

a)

combining several polypeptide chains into fibrillar structures

b)

the order of alternation of amino acids linked by peptide bonds in the protein

c)

structure of a polypeptide chain stabilized by hydrogen bonds between peptide atoms

d)

linear structure of a polypeptide chain formed by covalent bonds between amino acid radicals

e)

method of laying protomers in an oligomeric protein

39.

To full-valued proteins are proteins that ...

a)

do not contain at least one interchangeable amino acid.

b)

contain all the essential amino acids.

c)

do not contain at least one essential amino acid.

d)

do not contain all interchangeable amino acids.

e)

contain all the interchangeable amino acids.

40.

Denaturation of the protein is:

a)

violation of native protein conformation

b)

restoration of the native conformation of the damaged protein

c)

hydrate formation

d)

restoration of ionogenic activity of the protein

e)

process of rupturing peptide bonds of protein

41.

Metalloproteins in the body perform ... functions.

a)

protective, respiratory

b)

respiratory, catalytic

c)

depositing, respiratory

d)

transport, catalytic

e)

energy, depositing

42.

The charge of protein in the solution depends on:

a)

temperatures

b)

of the isoelectric point of the protein

c)

number of peptide bonds

d)

the number of hydrogen bonds

e)

pH of the solution

43.

The respiratory enzymes belong to the class:

a)

hydrolase

b)

transferraz

c)

oxidoreductase

d)

ligase

e)

isomerase

44.

Enzymes accelerate reactions by ...

a)

lowering the energy barrier.

b)

Enzymes accelerate reactions by ...

c)

increase activation energy.

d)

increase the activation energy, lowering the barrier.

e)

increase of the barrier and activation energy.

45.

Competitive inhibitor ...

a)

binds to the site of the molecule outside the active center of the enzyme.

b)

acts at the enzyme-substrate complex stage.

c)

binds to the substrate.

d)

binds to the active center of the enzyme.

e)

destroys the enzyme.

46.

Isozymes - molecular forms of enzymes that ...

a)

are contained in one organ.

b)

do not differ in their physicochemical properties.

c)

have identical coenzymes and differ in the structure of the apoenzyme.

d)

have different coenzymes and identical apoenzymes.

e)

act on different substrates.

47.

Enzymes show absolute substrate specificity in relation to ...

a)

substrate with a similar structure.

b)

one substrate.

c)

a certain connection.

d)

specific pH and temperature.

e)

specific pH, temperature and pressure.

48.

Substrate phosphorylation is a synthesis ...

a)

AMF.

b)

ATP.

c)

FADN-N.

d)

NADN-N.

e)

ADP.

49.

The source of NADPH2 in the synthesis of FFA is:

a)

glycolysis

b)

CTA

c)

malabsorption shunt

d)

pentose-phosphate cycle

e)

Corey cycle

50.

How many ATP molecules are formed upon complete oxidation of NADH2:

a)

6

b)

5

c)

4

d)

3

e)

1

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