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Antimicrobials & Anthelminthics

Total questions: 30

Worksheet time: 16mins

Name
Class
Date
1.

Which of the following drugs inhibit cell wall synthesis in bacteria?

a)

Erythromycin

b)

Streptomycin

c)

Vancomycin

d)

Clindamycin

2.

All of the following drugs are bacteriostatic except:

a)

Chloramphenicol

b)

Clindamycin

c)

Bacitracin

d)

Linezolid

3.

Antianabolic effect is shown by:

a)

Vancomycin

b)

Chloramphenicol

c)

Amphotericin B

d)

Tetracycline

4.

Streptomycin resistance of E. coli is transferred by:

a)

Conjugation

b)

Transformation

c)

Transduction

d)

Mutation

5.

Select the drugs that have enzyme inactivation in mutant strains:

a)

Cephalosporins

b)

Chloramphenicol

c)

Fluoroquinolones

d)

Aminoglycosides

6.

Conditions predisposing to superinfection include all except:

a)

Diabetes

b)

Hypertension

c)

SLE

d)

AIDS

7.

A person using clindamycin developed abdominal pain and bowel dysfunction. The diagnosis of a superinfection was made. Endoscopy shows plaques in gut mucosa. The organism is:

a)

Candida albicans

b)

Clostridium difficile

c)

Proteus

d)

Pseudomonas

8.

Drug causing malabsorption syndrome:

a)

Cotrimoxazole

b)

Vancomycin

c)

Nystatin

d)

Neomycin

9.

Kernicterus is seen in infants due to:

a)

Aminoglycosides

b)

Sulphonamides

c)

Chloramphenicol

d)

Tetracyclines

10.

Drug to be avoided in hepatic dysfunction include all except:

a)

Pefloxacin

b)

Tetracycline

c)

Chloramphenicol

d)

Nalidixic acid

11.

Drugs to be avoided in G-6-PD deficient patient includes all except:

a)

Primaquine

b)

Chloramphenicol

c)

Fluoroquinolones

d)

Tetracyclines

12.

Drug not showing long post antibiotic effect:

a)

Fluoroquinolones

b)

Vancomycin

c)

Rifampin

d)

Aminoglycosides

13.

Concentration dependent killing is seen with:

a)

Penicillin

b)

Vancomycin

c)

Streptomycin

d)

Macrolides

14.

Antagonism is seen with

a)

Penicillin + Vancomycin

b)

Penicillin + Erythromycin

c)

Penicillin + Metronidazole

d)

Penicillin + Streptomycin

15.

Prophylaxis for H1N1 influenza is done using:

a)

Acyclovir

b)

Ganciclovir

c)

Oseltamivir

d)

Tenofovir

16.

Choose the wrong match

a)

Metronidazole - inhibit β-tubulin polymerisation

b)

DEC - Alter organelle membranes

c)

Piperazine - GABA agonist

d)

Pyrantel - inhibit nicotinic cholinergic receptors

17.

Drug of choice in trichuriasis

a)

Albendazole

b)

Ivermectin

c)

Mebendazole

d)

Pyrantel pamoate

18.

Choose the false statement about Albendazole

a)

Taken with fatty meal for ascariasis

b)

Metabolite is albendazole sulfoxide

c)

Contraindicated in pregnancy

d)

Single dose treatment for Enterobius

19.

Which of the following drugs are contraindicated in epilepsy?

a)

Piperazine

b)

Praziquantel

c)

Niclosamide

d)

Pyrantel pamoate

20.

Drug with immunomodulator action

a)

Piperazine

b)

Levamisole

c)

Albendazole

d)

Ivermectin

21.

DEC kills adult worms of all except:

a)

Wuchereria bancrofti

b)

Loa loa

c)

Oncocerca volvulus

d)

Brugia malayi

22.

Ivermectin is obtained from

a)

Streptomyces coelicolor

b)

Streptomyces avermitilis

c)

Streptomyces scabies

d)

Streptomyces rimosus

23.

Drug of choice for river blindness

a)

DEC

b)

Ivermectin

c)

Praziquantel

d)

Albendazole

24.

Antibacterial drug acting as anthelminthic:

a)

Chloramphenicol

b)

Doxycycline

c)

Penicillin

d)

Vancomycin

25.

Drug inhibiting oxidative phosphorylation in helminthic mitochondria:

a)

Praziquantel

b)

Niclosamide

c)

DEC

d)

Pyrantel pamoate

26.

Choose the anthelminthics contraindicated in pregnancy:

a)

Piperazine

b)

Pyrantel pamoate

c)

Niclosamide

d)

Ivermectin

27.

Choose the true statement regarding Praziquantel

a)

Not used in ocular cysticercosis

b)

Kills only adult worms

c)

Does not cross BBB

d)

DOC for neurocysticercosis

28.

All of the following reduce bioavailability of praziquantel except:

a)

Phenytoin

b)

Carbamazepine

c)

Dexamethasone

d)

Sodium valproate

29.

Drug of choice for visceral larva migrans

a)

Mebendazole

b)

DEC

c)

Albendazole

d)

Ivermectin

30.

Albendazole absorption is enhanced by:

a)

Phenytoin

b)

Dexamethasone

c)

Vancomycin

d)

Tetracycline

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