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Med Chem - Glycolysis

Total questions: 73

Worksheet time: 38mins

Name
Class
Date
1.

Full oxidation of glucose yields:

a)

2840 kJ/mol

b)

3550 kJ/mol

c)

100 kJ/mol

d)

2560 kJ/mol

2.

Glucose is stored in ______ form because it is a potent ______

a)

polymeric, osmolyte

b)

monomeric, osmolyte

c)

multivalent, reducing agent

d)

polymeric, pedialyte

3.

Roles of glucose:

a)

generate energy (ATP)

b)

precursor of amino acids, nucleotides, coenzymes, fatty acids, etc.

c)

lowering blood sugar

d)

longterm energy storage

4.

Which term refers to the amount of glucose in blood

a)

glycemia

b)

sugar

c)

diabetes

d)

gluconeogenesis

5.

The amount of glucose in the blood is the result of a combination of processes in which glucose is produced or consumed

a)

True

b)

False

6.

Which refers to the process of breaking down glycogen to glucose?

a)

glycogenolysis

b)

gluconeogenesis

c)

glycolysis

d)

glycogenesis

7.

Which refers to the process of breaking down glucose into lactate?

a)

glycogenolysis

b)

gluconeogenesis

c)

glycolysis

d)

glycogenesis

8.

Which refers to the process of synthesizing glucose from lactate?

a)

glycogenolysis

b)

glycolysis

c)

gluconeogenesis

d)

glycogenesis

9.

Which refers to the process of synthesizing glycogen from glucose?

a)

glycogenolysis

b)

glycolysis

c)

gluconeogenesis

d)

glycogenesis

10.

The amount of glucose and its polymers available in the body are enough for:

a)

1-3 weeks

b)

3-5 months

c)

1-2 days

d)

2-4 hours

11.

Triglycerides are the main long-term energy reserve in the body

a)

True

b)

False

12.

Which of the following is an energy form intended for immediate use inside of cells?

a)

Triglycerides

b)

Glucose

c)

ATP

d)

Protein

13.

What is another name for glycolysis?

a)

The Embden-Meyerhof Pathway

b)

The Pentose Phosphate Pathway

c)

The Gallagher-McDonnell Pathway

d)

Gluconeogenesis

14.

How many steps are included in glycolysis?

a)

5

b)

10

c)

38

d)

7

15.

What are the products of glycolysis of one molecule of glucose?

a)

2 pyruvate (3C) molecules

b)

2 ATP

c)

2 NADH

d)

1 Glycogen molecule

16.

Why do we distinguish two phases of glycolysis (preparatory and payoff)?

a)

glycolysis is an inefficient, redundant process

b)

breaking a C-C bond requires a lot of energy, so the molecule must be primed first

c)

the preparatory phase occurs outside of the cell, the payoff phase occurs inside of the cell

d)

to make the exam more difficult

17.

The overall process of glycolysis has a negative ΔG

a)

True

b)

False

18.

The preparatory phase (steps 1-5) results in:

a)

Production of one kinase molecule

b)

Conversion of glucose to 2 pyruvate molecules

c)

Production of 38 ATP

d)

Conversion of glucose to glyceraldehyde 3-phosphate

19.

Step 1 of glycolysis is catalyzed by which enzyme?

a)

Gluco-lysase

b)

phosphohexose isomerase

c)

hexokinase

d)

Aldolase

20.

In which step of glycolysis is glucose is phosphorylated to produce glucose 6-phosphate?

a)

1

b)

3

c)

7

d)

10

21.

Which enzyme catalyzes step 2 of glycolysis?

a)

Hexokinase

b)

Aldolase

c)

Phosphohexose isomerase

d)

Phosphofructokinase-1

22.

In which step of glycolysis is glucose 6-phosphase converted to fructose 6-phosphate?

a)

1

b)

2

c)

3

d)

4

23.

What type of reaction occurs in step 2 of glycolysis?

a)

phosphorylation

b)

ligation

c)

isomerization

d)

polymerization

24.

Step 3 of glycolysis is catalyzed by which enzyme?

a)

phosphohexose isomerase

b)

phosphofructokinase-1

c)

triose phosphate isomerase

d)

glycopolymerase

25.

Which step of glycolysis is this?


Fructose 6-phosphate ---> Fructose 1,6-Bisphosphate

a)

5

b)

2

c)

3

d)

4

26.

Which of the preparatory steps of glycolysis require ATP and are irreversible?

a)

1 and 3

b)

2 and 4

c)

7 and 10

d)

2 and 3

27.

Which enzyme catalyzes step 4 of glycolysis?

a)

Phosphohexose isomerase

b)

Triose phosphate isomerase

c)

Aldolase

d)

Phosphofructokinase-1

28.

Step 2 of glycolysis is irreversible

a)

True

b)

False

29.

Step 3 of glycolysis is irreversible

a)

True

b)

False

30.

Which step of glycolysis is this?


fructose 1,6-bisphosphate ---> glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

a)

3

b)

4

c)

5

d)

this does not occur during glycolysis

31.

Which type of reaction is catalyzed by phosphofructokinase-1?

a)

isomerization

b)

phosphorylation

c)

ligation

d)

polymerization

32.

Which step of glycolysis involves the cleavage of a 6-carbon molecule into two 3-carbon molecules?

a)

3

b)

4

c)

5

d)

10

33.

Which enzyme catalyzes step 5 of glycolysis?

a)

phosphohexose isomerase

b)

hexokinase

c)

aldolase

d)

triose phosphate isomerase

34.

What is the end result of the preparatory phase of glycolysis?

a)

two glyceraldehyde 3-phosphate molecules

b)

glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

c)

two pyruvate molecules

d)

2 ATP molecules

35.

The payoff phase of glycolysis results in:

a)

two pyruvate molecules

b)

2 net ATP

c)

2 NADH

d)

38 ATP

36.

Which two types of reactions occur during step 6 of glycolysis?

a)

isomerization

b)

phosphorylation

c)

oxidation

d)

hydration

37.

Which enzyme catalyzes step 6 of glycolysis?

a)

triose phosphate isomerase

b)

glyceraldehyde 3-phosphate dehydrogenase

c)

glyceraldehyde 3-phosphate reductase

d)

pentose phosphatase

38.

During which step of glycolysis is energy first harvested in the form of NADH?

a)

1

b)

3

c)

6

d)

10

39.

Which step of glycolysis is this?


2 Glyceraldehyde 3-phosphate + 2Pi + 2NAD+ ---> 2 1,3-Bisphosphoglycerate + 2NADH + H+

a)

5

b)

6

c)

7

d)

8

40.

In which step of glycolysis ATP first formed?

a)

1

b)

3

c)

7

d)

10

41.

Which enzyme catalyzes step 7 of glycolysis?

a)

phosphofructokinase-1

b)

phosphohexose isomerase

c)

phosphoglycerate kinase

d)

phosphoglycerate mutase

42.

Which step of glycolysis is this?


2 1,3-bisphosphoglycerate + 2ADP ---> 2 3-phosphoglycerate + 2ATP

a)

6

b)

7

c)

8

d)

9

43.

The second step of glycolysis in which energy is harvested is:

a)

6

b)

7

c)

8

d)

10

44.

Which enzyme catalyzes step 8 of glycolysis?

a)

phosphoglycerate kinase

b)

phosphoglycerate mutase

c)

phosphoglycerate isomerase

d)

glyceraldehyde 3-phosphate hydrogenase

45.

Which step of glycolysis is this?


2 3-phosphoglycerate ---> 2 2-phosphoglycerate

a)

6

b)

7

c)

8

d)

9

46.

What type of reaction occurs during step 8 of glycolysis?

a)

hydrolysis

b)

oxidation

c)

isomerization

d)

phosphorylation

47.

Which enzyme catalyzes step 9 of glycolysis?

a)

Phosphoglycerate kinase

b)

Phosphoglycerate mutase

c)

Enolase

d)

Glyceraldehyde 3-phosphate dehydrogenase

48.

Which of the following occurs during step 9 of glycolysis?

a)

hydrolysis

b)

dehydration

c)

phosphorylation

d)

isomerization

49.

Which step of glycolysis is this?


2 2-phosphoglycerate ---> 2 phosphoenolpyruvate

a)

7

b)

8

c)

9

d)

10

50.

Which enzyme catalyzes step 10 of glycolysis?

a)

Hexokinase

b)

Phosphoglycerate mutase

c)

Enolase

d)

Pyruvate kinase

51.

During which step of glycolysis does the second harvesting of ATP occur?

a)

7

b)

8

c)

9

d)

10

52.

Which step of glycolysis is this?


2 Phosphoenolpyruvate + 2ADP ---> 2 Pyruvate + 2ATP

a)

7

b)

8

c)

9

d)

10

53.

ΔG for all 10 steps of glycolysis is:

a)

-85 kJ/mol

b)

-2840 kJ/mol

c)

85 kJ/mol

d)

-250 kJ/mol

54.

Glycolysis is extremely efficient in terms of energy generation

a)

True

b)

False

55.

Where do most of the steps of glycolysis occur?

a)

Outside of the cell

b)

In the cytoplasm

c)

Inside the mitochondria

d)

Inside the endoplasmic reticulum

56.

Glycolysis extracts about ______ of the energy stored in a molecule of glucose

a)

1%

b)

5%

c)

50%

d)

85.7%

57.

How does glucose enter a cell?

a)

osmosis

b)

porin channels

c)

GLUT transporter

d)

efflux pumps

58.

Hexokinase requires which cofactor?

a)

Ca2+

b)

Fe2+

c)

NAD+

d)

Mg2+

59.

The human genome encodes four hexokinases. Which hexokinase is found only in hepatocytes?

a)

hexokinase I

b)

hexokinase II

c)

hexokinase III

d)

hexokinase IV

60.

Which is considered the first "committed" step of glycolysis?

a)

1

b)

3

c)

4

d)

5

61.

Each individual step of glycolysis has negative ΔG

a)

True

b)

False

62.

The steps of glycolysis tend to alternate between positive ΔG and negative ΔG.

a)

True

b)

False

63.

Why is step 7 of glycolysis bypassed in red blood cells?

a)

Step 7 can be bypassed in any cell

b)

RBCs have evolved a better way of performing glycolysis

c)

RBCs need 1,3-Bisphosphoglycerate to make 2,3-BPG

d)

The statement is false, step 7 is not bypassed in RBCs

64.

All 10 enzymes required for glycolysis are found in the cytoplasm of the cells

a)

True

b)

False

65.

Regulation of glycolosys occurs at the irreversible steps. Which steps of glycolysis are irreversible?

a)

1,3,7

b)

1,3,10

c)

2,4,8

d)

1,5,9

66.

The irreversible steps of glycolysis are regulated by:

a)

allosteric regulation by metabolites

b)

competitive inhibition by insulin

c)

enzyme denaturation due to drastic pH change

67.

Hexokinase is activated by:

a)

AMP, ADP, Pi, Fructose-6-phosphate

b)

Fructose-2,6-bisphosphate

c)

Glucose-6-phosphate

d)

AMP, Fructose-1,6-bisphosphate

68.

Hexokinase is inhibited by:

a)

Glucose-6-phosphate

b)

NADH, Citrate, ATP

c)

ATP, Acetyl-CoA

69.

Phosphofructokinase-1 is activated by:

a)

AMP, ADP, Pi, Fructose-6-phosphate

b)

Fructose-2,6-bisphosphate

c)

AMP, Fructose-1,6-bisphosphate

70.

Phosphofructokinase-1 is inhibited by:

a)

Glucose-6-phosphate

b)

NADH, Citrate, ATP

c)

ATP, Acetyl-CoA

71.

Pyruvate kinase is activated by:

a)

AMP, ADP, Pi, Fructose-6-phosphate

b)

Fructose-2,6-bisphosphate

c)

AMP, Fructose-1,6-bisphosphate

72.

Pyruvate kinase is inhibited by:

a)

Glucose-6-phosphate

b)

NADH, Citrate, ATP

c)

ATP, Acetyl-CoA

73.

Which enzyme catalyzes the step in which NADH is produced?

a)

Aldolase

b)

Glyceraldehyde 3-phosphate dehydrogenase

c)

Phosphoglycerate kinase

d)

Enolase

e)

Pyruvate kinase

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