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WorksheetsChapter 7 mutation
Total questions: 40
Worksheet time: 47mins
What is mutation?
Are more likely to be harmful than beneficial to human beings
Produce allelic variation and become fragile
Are permanent changes in the DNA sequence, amount or structure of chromosomes
Can be inherited from generation to the next generation if it occur in somatic cells
Gene mutation usually occurs during:
DNA repair
DNA replication
Cell division
DNA transcription
Which mutations would likely cause the greatest impact?
Inversion mutation
Frame-shift mutation
Silent mutation
Missense mutation
The original gene is ABC. The new sequence of gene is ACB. What is the type of chromosomal mutation occurred?
Insertion
Inversion
Deletion
Translocation
Point mutation involves
deletion
insertion
duplication
changes in single base pair
ATTTGAGCC- Original
ATTGAGCC - Mutated
The example above is an example of a
Insertion
Point mutation
Deletion
Substitution
Tick ALL examples of physical mutagens
X-ray
Gamma-ray
UV rays
Colchicine
A mutation in which only one nucleotide is altered is called a:
Frameshift Mutation
Deletion Mutation
Point Mutation
Insertion Mutation
When do random, or spontaneous, mutations happen?
During cell division
When cells are exposed to hazardous chemicals
When cells are exposed to certain viruses
When cells are exposed to radiation
A type of mutation that affect every codon beyond the point of mutation.
Point Mutation
Silent Mutation
Nonsense Mutation
Frameshift Mutation
What type of mutation is this?
Nonsense mutation
Missense mutation
Silent mutation
Frameshift mutation
ATT-TGA-GCC- Original
ATT-GAG-CC - Mutated
The example above is an example of a
Insertion- Frameshift
Deletion- Substitution
Deletion -Frameshift
All of the above
In sickle-cell anemia..
Glutamic acid is substituted with valine on Beta-polypeptide chain
Valine is substituted with glutamic acid on Beta-polypeptide chain
Glutamic acid is substituted with valine on alpha-polypeptide chain
Valine is substituted with glutamic acid on alpha-polypeptide chain
The polypeptide produced is truncated and short. The most likely type of point mutation that causes this is
Base substitution - nonsense mutation
Base substitution - missense mutation
Insertion mutation
Inversion mutation
The insertion of a base pair into the genetic code will cause frameshift mutation, unless the number of the base pairs inserted is
one
two
three
four
Inversion
When a segment of a chromosome breaks off.
When a segment of a chromosome breaks off, flips, and reattaches.
When a segment of a chromosome is copied or doubles.
When a segment of a chromosome breaks and attaches to a non homologous chromosome.
When entire chromosomes don't separate evenly during meiosis.
Nondisjunction of sex chromosomes may occur during meiosis I of spermatogenesis. Which of the following are the possible genotypes of the zygote if the normal ovum is fertilised by these two types of the sperms?
XXY and YO
XYY and YO
XXY and XO
XYY and XO
Which of the following is NOT an example of chromosomal mutations?
Substitution
Translocation
Inversion
Duplication
Which of the following is caused by deletion by a large part of short arm of chromosome 5?
Cri-Du-Chat
Thalassemia
Down syndrome
Sickle cell anaemia
Polyploidy refers to
Multiple ribosomes present on a single mRNA
a chromosome which has replicated but not divided
an individual with extra sets of chromosomes
extra copies of gene adjacent to each other on a chromosome
All these are TRUE about Turner syndrome, EXCEPT..
A disorder that affects female
The syndrome is known as Monosomy X
Affected individual has webbed neck
A disorder with an extra X chromosome
Which ONE is NOT a type of chromosomal aberration?
Deletion
Insertion
Inversion
Translocation
Which of the following are types of Euploidy? (answer can be more than ONE)
Polyploidy
Aneuploidy
Allopolyploidy
Autopolyploidy
A chromosome is found to be shorter than it's homologous match. Which type of mutation involved?
insertion
deletion
translocation
inversion
Addition or deletion of single number of chromosome refers to ____________
Aneuploidy
Euploidy
Autopolyploidy
Allopolyploidy
chromosomal alteration occur due to ______________.
crossing over
nondisjunction
anaphase I
prophase II
a diploid cell that is missing one chromosome of a homologous pair
aneuploidy
monosomy
nondisjunction
trisomy
It is characterized with an extra chromosome on chromosome 21. What type of aneuploidy is being referred?
Down Syndrome
Klinefelter Syndrome
Patau Syndrome
Turner Syndrome
What do you call a condition when a cell has an extra complete set of chromosomes due to errors in cell division?
Aneuploidy
Diploidy
Euploidy
Polyploidy
When does nondisjunction happen?
Two chromosomes combine into one
A portion of a chromosome breaks off
Members of a chromosome pair fail to detach
An entire pair of chromosomes failed to cross over
The diagram below represents the karyotype of a person with a genetic disorder.
Which is the likely cause of this condition?
nondisjunction during mitosis
nondisjunction during meiosis
chromosomal deletion during mitosis
chromosomal deletion during meiosis
A human egg cell might contain
22 autosomes and an X chromosome
22 autosomes and a Y chromosome
45 autosomes and an X chromosome
45 autosomes and a Y chromosome
polyploidy is important to the field of
medicines
embryology
agriculture
physics
