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Total questions: 50

Worksheet time: 27mins

Name
Class
Date
1.

Formula for serum osmolality:

a)

(2Na+) + (Glucose/20) + (BUN/3)

b)

(Na+/3) + (2Glucose) + (BUN/20)

c)

Na+ + 3Glucose + 2BUN

d)

Na+ - ( Cl- + total CO2)

2.

Later models of flame photometer uses_____ as an internal standard that allows the operator to measure sodium, potassium and lithium directly.

a)

Lithium

b)

Cesium

c)

Magnesium

d)

Calcium

3.

When measuring potassium using an ion selective electrode, the membrane is composed of:

a)

Glass

b)

Plastic

c)

Silver

d)

Valinomycin

4.

Which electrolytes are elevated in cystic fibrosis?

a)

Calcium and chloride

b)

Chloride and sodium

c)

Sodium and potassium

d)

Potassium and chloride

5.

In the blood, bicarbonate leaves the red blood cell and enters the plasma through an exchange mechanism with:

a)

Sodium

b)

Potassium

c)

Chloride

d)

Phosphate

6.

It is an essential component of the glucose tolerance factor, thought to play a role in maintaining normal insulin response to glucose load by affecting membrane response to insulin:

a)

Chromium

b)

Zinc

c)

Nickel

d)

Molybdenum

7.

Increased chloride levels as determined by colorimetric and ion-selective electrode methods may be caused by the presence in the solution of:

a)

Bromide

b)

Calcium

c)

Hydrogen

d)

Chylomicrons

8.

Which of the following is the primary mechanism causing respiratory alkalosis?

a)

Hyperventilation

b)

Hypoventilation

c)

Deficient pulmonary perfusion

d)

Parasympathetic inhibition

9.

If a blood gas specimen is left exposed to the air for an extended period of time, which of the following changes will occur?

a)

PO2 and pH increase; PCO2 decreases

b)

PO2 and pH decrease; PCO2 increases

c)

PO2 increases; pH and PCO2 decrease

d)

PO2 decreases; pH and PCO2 increase

10.

Sealed heparinized arterial blood was left at room temperature for 2 hours. The most likely changes in PO2 (mmHg), PCO2(mm Hg), and pH, respectively, are:

a)

Increase, increase and increase

b)

Decrease, decrease, and decrease

c)

Decrease, increase, and decrease

d)

Decrease, decrease, and increase

11.

The adrenal medulla secretes which of the following in the greatest quantity?

a)

Metanephrine

b)

Noradrenaline

c)

Epinephrine

d)

Dopamine

12.

Homovanillic acid is the principal urine metabolite of:

a)

Norepinephrine

b)

Epinephrine

c)

Adrenaline

d)

Dopamine

13.

Diurnal variation is important to consider when collecting blood for the assay of:

a)

Catecholamines

b)

Creatinine

c)

Cortisol

d)

Thyroid hormones

14.

T3 uptake is actually a measurement of:

a)

T3

b)

T4

c)

TBG

d)

Free thyroxine

15.

Active hormonal form of T3 an T4:

a)

Those bound to TBG

b)

Those bound to albumin

c)

Those bound to transthyretin

d)

Those in free form

16.

The principle is based on the reaction of urinary estrogen with a mixture of phenol and sulfuric acid to produce pink color. This refers to:

a)

Kober reaction

b)

Trinder reaction

c)

Zimmermann reaction

d)

Porter-Silber reaction

17.

The Kober reaction is used in the assay of:

a)

Urinary estrogen

b)

Glucocorticoids

c)

Testosterone

d)

Epinephrine

18.

In the Porter-Silber assay, the dihydroxyacetone side chain of the steroid hormone reacts with:

a)

Sulfuric acid-hydroquinone and forms reddish-brown color

b)

m-dinitrobenzene and forms purple color

c)

Ceric and arsenite compound and forms a yellow product

d)

2, 4–dinitrophenylhydrazine and forms a yellow derivative

19.

The assay employed for 17-ketosteroids, in which steroids react with m-dinitrobenzene in alcoholic KOH solution resulting to the formation of a purple color:

a)

Kober Reaction

b)

Zimmerman reaction

c)

Porter-Silber Reaction

d)

Pisano Method

20.

Zollinger-Ellison syndrome is characterized by elevated blood levels of:

a)

Cholecystokinin

b)

Trypsin

c)

Pepsin

d)

Gastrin

21.

Tumor marker most useful in the detection of familial medullary carcinoma of the thyroid:

a)

Calcitonin

b)

CA 125

c)

CEA

d)

CA 19-9

22.

What metal toxin in urine is detected by the Reinsch test?

a)

Lead

b)

Mercury

c)

Bromide

d)

Zinc

23.

Trinder’s reagent (mercuric chloride, HCl, and ferric nitrate) is used in the colometric assay for:

a)

Acetaminophen

b)

Salicylate

c)

Theophylline

d)

Ethanol

24.

Caffeine is an important metabolite of this drug, which is assayed in newborns and young children to monitor its therapeutic level. What is this?

a)

Acetaminophen

b)

Digoxin

c)

Theophylline

d)

Phenobarbital

25.

Odor of bitter almond gives a clue of:

a)

Cyanide poisoning

b)

Ethanol poisoning

c)

Arsenic poisoning

d)

Carbon monoxide poisoning

26.

Benzoylecgonine is the major metabolite of:

a)

Heroin

b)

Marijuana

c)

Cocaine

d)

Phencyclidine

27.

The formation of this crystal in urine, although not a constant finding is an important diagnostic clue of ethylene glycol poisoning:

a)

Uric acid

b)

Ammonium biurate

c)

Triple phosphate

d)

Calcium oxalate

28.

What is the major carrier of drugs in the circulation?

a)

Albumin

b)

Globulin

c)

Transferrin

d)

Hemoglobin

29.

Fire extinguishers designated as Class A are used for:

a)

Paper and wood

b)

Electrical equipment fire

c)

Flammable liquids and gases

d)

AOTA

30.

It is a specialized colorimeter designed to scan and quantitate electrophoresis patterns:

a)

Densitometer

b)

Detector

c)

Atomizer

d)

Monochromator

31.

The element that distinguishes proteins from carbohydrate and lipid compounds is:

a)

Carbon

b)

Oxygen

c)

Nitrogen

d)

Phosphorus

32.

Parfentjev’s method is for the determination of:

a)

Fibrinogen

b)

Albumin

c)

Globulin

d)

Amylase

33.

Apolipoprotein A is the primary protein component of:

a)

HDL

b)

IDL

c)

LDL

d)

VLDL

34.

It is biologically important, as it serves as the starting point in many metabolic pathways including Vitamin D synthesis, steroid hormone synthesis, and bile acid metabolism.

a)

Cholesterol

b)

Phospholipid

c)

Triglycerides

d)

Free fatty acids

35.

What is the current reference method for cholesterol analysis?

a)

Abell-Kendall method

b)

Bloor’s method

c)

Salkowski method

d)

Lieberman-Burchardt

36.

A mild condition that appears to result from a genetic defect in transport of bilirubin from sinusoidal blood into the hepatocyte:

a)

Gilbert Syndrome

b)

Crigler-Najjar Syndrome

c)

Dubin-Johnson

d)

Rotor Syndrome

37.

What reagent is used in the Evelyn-Malloy method to dissociate the unconjugated bilirubin from protein?

a)

Methanol

b)

Ethanol

c)

Caffeine

d)

Acetic acid

38.

The Jaffe reaction is employed for the quantitation of:

a)

Urea

b)

Creatinine

c)

Protein

d)

Uric acid

39.

Lloyd’s reagent improves the specificity of what colorimetric method of determination?

a)

Jaffe

b)

Caraway

c)

Lieberman-Burchardt

d)

Biuret

40.

What is the major end product of protein and amino acid catabolism?

a)

Urea

b)

Uric acid

c)

Creatinine

d)

Creatine

41.

Uric acid when oxidized by the enzyme uricase is transformed to:

a)

Allantoin

b)

Monosodium urate

c)

Xanthine

d)

Ammonia

42.

The sweat chloride test is useful in the diagnosis of:

a)

Dehydration

b)

Cystic fibrosis

c)

Azotemia

d)

Diabetes

43.

Which trace metal accumulates in Wilson’s disease?

a)

Cobalt

b)

Copper

c)

Nickel

d)

Zinc

44.

The pH of blood is critically maintained at what level:

a)

7.00-7.50

b)

7.50-7.70

c)

7.15-7.35

d)

7.35-7.45

45.

In which of the following are the thyroid hormones classified:

a)

Amino acid derivatives

b)

Steroid hormones

c)

Fatty acid derivatives

d)

Peptide hormones

46.

Which of the following polypeptide hormones may be described as having alpha chains that are biochemically identical but beta chains that are biochemically unique?

a)

FSH, TSH, ACTH, LH

b)

TSH, LH, TRH, HCG

c)

LH, ACTH, HCG, TRH

d)

HCG, FSH, TSH, LH

47.

The thyroid gland produces all of the following hormones EXCEPT:

a)

TSH

b)

Calcitonin

c)

Thyroxine

d)

Triidothyronine

48.

In hypothyroidism, one would expect the total T4 level to be _____, and the T3 uptake to be ____.

a)

Increased, increased

b)

Decreased, decreased

c)

Decreased, increased

d)

Increased, decreased

49.

How can primary hypothyroidism be differentiated from secondary hypothyroidism?

a)

T3

b)

T4

c)

TSH

d)

T3 and T4

50.

5-Hydroxyindoleacetic acid is the primary metabolite of:

a)

Epinephrine

b)

Prolactin

c)

Norepinephrine

d)

Serotonin