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WorksheetsPharmacology I
Total questions: 25
Worksheet time: 13mins
The minimum amount of drug needed to produce the desired therapeutic effect is:
Tolerance
Tachyphylaxis
Potency
Efficacy
Genetic polymorphism known as SNIPs is studied in:
A. Pharmacokinetics
B. Pharmacovigilance
C. Pharmacogenomics
D. Ethnopharmacology
Combination of drug that produces synergistic action is:
A. 1 + 1 = 2
B. 1 + 0 = 0
C. 1 + 1 =11
D. 1 + 0 = >1
TI (therapeutic index) is 5. The safety of the drug is:
A. Wide
B. Narrow
C. Full
D. Partial
What is the most dreaded ADR of hydralazine, a vasodilator in HPN?
SLE
SJS
NMS
SS
All of the following are true regarding Fluocytosine, EXCEPT:
a. Should be given together with Amphotericin B in cryptococcal meningitis
b. Has a characteristic good bioavailability with significant CNS penetration
c. Carefully given in functionally anephric patients because of narrow therapeutic window
d. Does not cause bone marrow toxicity because of its relativeness to Flourouracil.
Drug of choice for Invasive Aspergillosis:
a. Ketoconazole
b. Clotrimazole
c. Voriconazole
d. Fluconazole
Orally available imidazole agent:
a. Miconazole
b. Ketoconazole
c. Itraconazole
d. Voriconazole
Systemic antifungal drug for mucocutaneous infections that inhibit squalene epoxidase
a. Griseofulvin
b. Terbinafine
c. Nystatin
d. Clotrimazole
Blocks or inhibit viral attachment and entry, EXCEPT:
a. Palivizumab
b. Enfuvirtide
c. Acyclovir
d. Doconasol
It is an analog of Sialic acid interfering with the release of viral progeny:
a. Rimantadine
b. Amantadine
c. Oseltamivir
d. Acyclovir
It is a drug that acts on the tissue hypnozoites (dormant hypnozoites) thereby causing radical cure:
a. Mefloquine
b. Quinine
c. Primaquine
d. clindamycin
It is an antimalarial drug that acts on gametocytes of all human plasmodia thereby preventing transmission:
AChloroquine
b. Quinine
c. Primaquine
D. Mefloquine
All of the following protozoan infections can be treated with metronidazole, EXCEPT:
a. Leishmaniasis
b. Trichomoniasis
c. Amoebiasis
d. Backpacker’s diarrhea
A reserve agent that is used in HIV/AIDS patients with Pneumocystis jiroveci pneumonia who can not tolerate Trimethoprim-Sulfamethoxazole for any reason:
a. Aerosolized tobramycin
b. Pentamidine
c. Clarithromycin
d. Rifamycin
All of the following parasitic infections are ideally and preferentially treated by Albendazole, EXCEPT:
a. Echinococcus granulosus infection
b.Wuchereria bancrofti
c. Neurocysticercosis
d. Ascariasis
Fluoroquinolone that is most active against Pseudomonas aeruginosa:
a. Ciprofloxacin
b. Moxifloxacin
c. Gatifloxacin
d. Levofloxacin
Pharmacologic effects of the classic anti histamines (H1-receptor antagonists) include all of the ff. except
a. An antipruritic effect
b. Inhibition of gastric secretion
c. Prevention of motion sickness
d. Sedation with low doses
A 20 yr old student was bitten by a dog in the face as he enters the gate. The dog escapes through the open gate and cannot be found. You should advice the visitor to cleanse the wound with soap and water and
a. Penicillin and rabies vaccine
b. Penicillin
c. Rabies vaccine and rabies immunoglobulin
d. Penicillin, rabies vaccine and rabies immunoglobulin
Major clinical uses of immunosuppressant
a. autoimmune disorders
b. hemolytic Dis of NB
c. bone marrow transplantation
d. chronic severe asthma
e. All of the above
Re-distribution phenomenon of drugs as thiopental Na+ will:
A. Enhanced drug action
B. Modulate drug action
C. Terminate Drug Action
D. Accelerate drug action
An inactivated virus vaccine
a. Mumps
b. Varicella
c. IPV
d. OPV
Evanescent tolerance to a general anesthetic agent is:
A. Anaphylaxis
B. Tachyphylaxis
C. Idiosyncrasy
D. Addiction
Morphine + naloxone produces this type of antagonism:
A. Competitive
B. Noncompetitive
C. Physiologic
D. Chemical
Analgesic-antipyretic-antithrombotic that produces ADRs as bleeding and hyperacidity is
A. Paracetamol
B. Aspirin
C. Diazepam
D. Chloroquine
